Detail Information

Basic Information:


  VIRBase ID:  

VHID00427431

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           ACBD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b ACBD3
miRBase
Accession/Entrez ID		 MIMAT0002180 64746
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - GCP60//GOCAP1//GOLPH1//PAP7

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACBD3
chr1:226361667(-) A-I      intronic
chr1:226361643(-) A-I      intronic
chr1:226361640(-) A-I      intronic
chr1:226350595(-) A-I      intronic
chr1:226359744(-) A-I      intronic
chr1:226359780(-) A-I      intronic
chr1:226361642(-) A-I      intronic
chr1:226361631(-) A-I      intronic
chr1:226361632(-) A-I      intronic
chr1:226361636(-) A-I      intronic
chr1:226359774(-) A-I      intronic
chr1:226361637(-) A-I      intronic
chr1:226359748(-) A-I      intronic
chr1:226356692(-) A-I      intronic
chr1:226351656(-) A-I      intronic
chr1:226371886(-) A-I      intronic
chr1:226371770(-) A-I      intronic
chr1:226356720(-) A-I      intronic
chr1:226357678(-) A-I      intronic
chr1:226359669(-) A-I      intronic
chr1:226358538(-) A-I      intronic
chr1:226358557(-) A-I      intronic
chr1:226371703(-) A-I      intronic
chr1:226371696(-) A-I      intronic
chr1:226358573(-) A-I      intronic
chr1:226339544(-) A-I      intronic
chr1:226339664(-) A-I      intronic
chr1:226371658(-) A-I      intronic
chr1:226371528(-) A-I      intronic
chr1:226371523(-) A-I      intronic
chr1:226368648(-) A-I      intronic
chr1:226371463(-) A-I      intronic
chr1:226371112(-) A-I      intronic
chr1:226337339(-) A-I      intronic
chr1:226371089(-) A-I      intronic
chr1:226368661(-) A-I      intronic
chr1:226368614(-) A-I      intronic
chr1:226358586(-) A-I      intronic
chr1:226367512(-) A-I      intronic
chr1:226358629(-) A-I      intronic
chr1:226339686(-) A-I      intronic
chr1:226367507(-) A-I      intronic
chr1:226358692(-) A-I      intronic
chr1:226366229(-) A-I      intronic
chr1:226366194(-) A-I      intronic
chr1:226366189(-) A-I      intronic
chr1:226366176(-) A-I      intronic
chr1:226366154(-) A-I      intronic
chr1:226366152(-) A-I      intronic
chr1:226366107(-) A-I      intronic
chr1:226366078(-) A-I      intronic
chr1:226358754(-) A-I      intronic
chr1:226339706(-) A-I      intronic
chr1:226360958(-) A-I      intronic
chr1:226360750(-) A-I      intronic
chr1:226360746(-) A-I      intronic
chr1:226360723(-) A-I      intronic
chr1:226360722(-) A-I      intronic
chr1:226360710(-) A-I      intronic
chr1:226358986(-) A-I      intronic
chr1:226359139(-) A-I      intronic
chr1:226360605(-) A-I      intronic
chr1:226360521(-) A-I      intronic
chr1:226360490(-) A-I      intronic
chr1:226360402(-) A-I      intronic
chr1:226360401(-) A-I      intronic
chr1:226360389(-) A-I      intronic
chr1:226351630(-) A-I      intronic
chr1:226359640(-) A-I      intronic
chr1:226371718(-) A-I      intronic
chr1:226359516(-) A-I      intronic
chr1:226359486(-) A-I      intronic
chr1:226359427(-) A-I      intronic
chr1:226359414(-) A-I      intronic
chr1:226359141(-) A-I      intronic
chr1:226337327(-) A-I      intronic
chr1:226337334(-) A-I      intronic
chr1:226337349(-) A-I      intronic
chr1:226359377(-) A-I      intronic
chr1:226359363(-) A-I      intronic
chr1:226337422(-) A-I      intronic
chr1:226359269(-) A-I      intronic
chr1:226359145(-) A-I      intronic
chr1:226351642(-) A-I      intronic
chr1:226360505(-) A-I      intronic
chr1:226371502(-) A-I      intronic
chr1:226358147(-) A-I      intronic
chr1:226360163(-) A-I      intronic
chr1:226356570(-) A-I      intronic
chr1:226334864(-) A-I      intronic
chr1:226365037(-) A-I      intronic
chr1:226354234(-) A-I      intronic
chr1:226359708(-) A-I      intronic
chr1:226334825(-) A-I      intronic
chr1:226359416(-) A-I      intronic
chr1:226357479(-) A-I      intronic
chr1:226361615(-) A-I      intronic
chr1:226357540(-) A-I      intronic
chr1:226371450(-) A-I      intronic
chr1:226359336(-) A-I      intronic
chr1:226359026(-) A-I      intronic
chr1:226351741(-) A-I      intronic
chr1:226357575(-) A-I      intronic
chr1:226357659(-) A-I      intronic
chr1:226359412(-) A-I      intronic
chr1:226368449(-) A-I      intronic
chr1:226357684(-) A-I      intronic
chr1:226365529(-) A-I      intronic
chr1:226359046(-) A-I      intronic
chr1:226358645(-) A-I      intronic
chr1:226358635(-) A-I      intronic
chr1:226360164(-) A-I      intronic
chr1:226371461(-) A-I      intronic
chr1:226359009(-) A-I      intronic
chr1:226361624(-) A-I      intronic
chr1:226371835(-) A-I      intronic
chr1:226370967(-) A-I      intronic
chr1:226359612(-) A-I      intronic
chr1:226365694(-) A-I      intronic
chr1:226372567(-) A-I      intronic
chr1:226334623(-) A-I      intronic
chr1:226359481(-) A-I      intronic
chr1:226371533(-) A-I      intronic
chr1:226354084(-) A-I      intronic
chr1:226371473(-) A-I      intronic
chr1:226357348(-) A-I      intronic
chr1:226358080(-) A-I      intronic
chr1:226359321(-) A-I      intronic
chr1:226334655(-) A-I      intronic
chr1:226334841(-) A-I      intronic
chr1:226358717(-) A-I      intronic
chr1:226371025(-) A-I      intronic
chr1:226351817(-) A-I      intronic
chr1:226365512(-) A-I      intronic
chr1:226353985(-) A-I      intronic
chr1:226359406(-) A-I      intronic
chr1:226368618(-) A-I      intronic
chr1:226358650(-) A-I      intronic
chr1:226371015(-) A-I      intronic
chr1:226371155(-) A-I      intronic
chr1:226360922(-) A-I      intronic
chr1:226360749(-) A-I      intronic
chr1:226367528(-) A-I      intronic
chr1:226363970(-) A-I      intronic
chr1:226334817(-) A-I      intronic
chr1:226334721(-) A-I      intronic
chr1:226350622(-) A-I      intronic
chr1:226357991(-) A-I      intronic
chr1:226370907(-) A-I      intronic
chr1:226365544(-) A-I      intronic
chr1:226371169(-) A-I      intronic
chr1:226364902(-) A-I      intronic
chr1:226350613(-) A-I      intronic
chr1:226361559(-) A-I      intronic
chr1:226363872(-) A-I      intronic
chr1:226359747(-) A-I      intronic
chr1:226359699(-) A-I      intronic
chr1:226354059(-) A-I      intronic
chr1:226358148(-) A-I      intronic
chr1:226358605(-) A-I      intronic
chr1:226357643(-) A-I      intronic
chr1:226371423(-) A-I      intronic
chr1:226356743(-) A-I      intronic
chr1:226371880(-) A-I      intronic
chr1:226365027(-) A-I      intronic
chr1:226360764(-) A-I      intronic
chr1:226356655(-) A-I      intronic
chr1:226371498(-) A-I      intronic
chr1:226357583(-) A-I      intronic
chr1:226356702(-) A-I      intronic
chr1:226365568(-) A-I      intronic
chr1:226368617(-) A-I      intronic
chr1:226359324(-) A-I      intronic
chr1:226357077(-) A-I      intronic
chr1:226371888(-) A-I      intronic
chr1:226350728(-) A-I      intronic
chr1:226366027(-) A-I      intronic
chr1:226359707(-) A-I      intronic
chr1:226350614(-) A-I      intronic
chr1:226359122(-) A-I      intronic
chr1:226334714(-) A-I      intronic
chr1:226360732(-) A-I      intronic
chr1:226354060(-) A-I      intronic
chr1:226371420(-) A-I      intronic
chr1:226357566(-) A-I      intronic
chr1:226350715(-) A-I      intronic
chr1:226357384(-) A-I      intronic
chr1:226350666(-) A-I      intronic
chr1:226359344(-) A-I      intronic
chr1:226364959(-) A-I      intronic
chr1:226354325(-) A-I      intronic
chr1:226371847(-) A-I      intronic
chr1:226339632(-) A-I      intronic
chr1:226351745(-) A-I      intronic
chr1:226358609(-) A-I      intronic
chr1:226360939(-) A-I      intronic
chr1:226364897(-) A-I      intronic
chr1:226359600(-) A-I      intronic
chr1:226371041(-) A-I      intronic
chr1:226360787(-) A-I      intronic
chr1:226362404(-) A-I      intronic
chr1:226365608(-) A-I      intronic
chr1:226360188(-) A-I      intronic
chr1:226358659(-) A-I      intronic
chr1:226357560(-) A-I      intronic
chr1:226361692(-) A-I      intronic
chr1:226353994(-) A-I      intronic
chr1:226359407(-) A-I      intronic
chr1:226360189(-) A-I      intronic
chr1:226354412(-) A-I      intronic
chr1:226371829(-) A-I      intronic
chr1:226358070(-) A-I      intronic
chr1:226365588(-) A-I      intronic
chr1:226359494(-) A-I      intronic
chr1:226365169(-) A-I      intronic
chr1:226371063(-) A-I      intronic
chr1:226358662(-) A-I      intronic
chr1:226358711(-) A-I      intronic
chr1:226365582(-) A-I      intronic
chr1:226360861(-) A-I      intronic
chr1:226357626(-) A-I      intronic
chr1:226334704(-) A-I      intronic
chr1:226365604(-) A-I      intronic
chr1:226371468(-) A-I      intronic
chr1:226353940(-) A-I      intronic
chr1:226361641(-) A-I      intronic
chr1:226353954(-) A-I      intronic
chr1:226361702(-) A-I      intronic
chr1:226334713(-) A-I      intronic
chr1:226350755(-) A-I      intronic
chr1:226334837(-) A-I      intronic
chr1:226368455(-) A-I      intronic
chr1:226359403(-) A-I      intronic
chr1:226365637(-) A-I      intronic
chr1:226357614(-) A-I      intronic
chr1:226359277(-) A-I      intronic
chr1:226371554(-) A-I      intronic
chr1:226357604(-) A-I      intronic
chr1:226357466(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ACBD3
chr1:226334655(-) A-I intron -    15342557
chr1:226334668(-) A-I intron -    15342557
chr1:226334704(-) A-I intron -    15342557
chr1:226334713(-) A-I intron -    15342557
chr1:226334714(-) A-I intron -    15342557
chr1:226334721(-) A-I intron -    15342557
chr1:226334825(-) A-I intron -    15342557
chr1:226334837(-) A-I intron -    15342557
chr1:226334841(-) A-I intron -    15342557
chr1:226357604(-) A-I intron -    22327324
chr1:226356731(-) A-I intron -    21960545
chr1:226358605(-) A-I intron -    21960545
chr1:226358717(-) A-I intron -    21960545
chr1:226359145(-) A-I intron -    21960545
chr1:226360163(-) A-I intron -    21960545
chr1:226360189(-) A-I intron -    21960545
chr1:226360210(-) A-I intron -    21960545
chr1:226360861(-) A-I intron -    21960545
chr1:226354054(-) C-T intron -    22484847
chr1:226354059(-) A-G intron -    22484847
chr1:226354060(-) A-G intron -    22484847
chr1:226354084(-) A-G intron -    22484847
chr1:226357604(-) A-G intron -    22484847
chr1:226357614(-) A-G intron -    22484847
chr1:226358605(-) A-G intron -    22484847
chr1:226358659(-) A-G intron -    22484847
chr1:226358717(-) A-G intron -    22484847
chr1:226359122(-) A-G intron -    22484847
chr1:226359277(-) A-G intron -    22484847
chr1:226359321(-) A-G intron -    22484847
chr1:226359324(-) A-G intron -    22484847
chr1:226359336(-) A-G intron -    22484847
chr1:226359344(-) A-G intron -    22484847
chr1:226359407(-) A-G intron -    22484847
chr1:226359412(-) A-G intron -    22484847
chr1:226359481(-) A-G intron -    22484847
chr1:226359494(-) A-G intron -    22484847
chr1:226359612(-) A-G intron -    22484847
chr1:226359747(-) A-G intron -    22484847
chr1:226360163(-) A-G intron -    22484847
chr1:226360764(-) A-G intron -    22484847
chr1:226361708(-) C-G intron -    22484847
chr1:226365037(-) A-G intron -    22484847
chr1:226365512(-) A-G intron -    22484847
chr1:226365544(-) A-G intron -    22484847
chr1:226365568(-) A-G intron -    22484847
chr1:226365604(-) A-G intron -    22484847
chr1:226365608(-) A-G intron -    22484847
chr1:226365694(-) A-G intron -    22484847
chr1:226368449(-) A-G intron -    22484847
chr1:226368455(-) A-G intron -    22484847
chr1:226368617(-) A-G intron -    22484847
chr1:226368618(-) A-G intron -    22484847
chr1:226370907(-) A-G intron -    22484847
chr1:226370967(-) A-G intron -    22484847
chr1:226371015(-) A-G intron -    22484847
chr1:226371025(-) A-G intron -    22484847
chr1:226371155(-) A-G intron -    22484847
chr1:226371169(-) A-G intron -    22484847
chr1:226371423(-) A-G intron -    22484847
chr1:226371461(-) A-G intron -    22484847
chr1:226371468(-) A-G intron -    22484847
chr1:226371498(-) A-G intron -    22484847
chr1:226371502(-) A-G intron -    22484847
chr1:226371533(-) A-G intron -    22484847
chr1:226371554(-) A-G intron -    22484847
chr1:226371835(-) A-G intron -    22484847
chr1:226371880(-) A-G intron -    22484847
chr1:226371888(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACBD3
chr1:226333370-226333371(-) m6A 3'UTR       26404942
chr1:226334012-226334013(-) m6A 3'UTR       27773535
chr1:226334107-226334108(-) m6A 3'UTR       24981863//27773535//22575960//22608085
chr1:226334150-226334151(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960//22608085
chr1:226334180-226334181(-) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960//22608085
chr1:226334440-226334441(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:226334518-226334519(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:226340037-226340038(-) m1A CDS       26863196
chr1:226340091-226340092(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:226340104-226340105(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:226340142-226340143(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:226340265-226340266(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr1:226340284-226340285(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr1:226342354-226342355(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr1:226342387-226342388(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr1:226342393-226342394(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr1:226342419-226342420(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr1:226342429-226342430(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr1:226342519-226342520(-) m6A CDS//exon       27773535
chr1:226346974-226346975(-) m6A CDS//intron       27773535
chr1:226346981-226346982(-) m6A CDS//intron       24209618//24981863//27773535
chr1:226347027-226347028(-) m6A CDS//intron       24209618//24981863//27773535//27371828
chr1:226347035-226347036(-) m6A CDS//intron       24209618//24981863//27773535//27371828
chr1:226349258-226349259(-) m1A CDS//exon       26863196
chr1:226349306-226349307(-) m1A CDS//exon       26863196
chr1:226349334-226349335(-) Am CDS       -
chr1:226352516-226352517(-) Tm CDS       -
chr1:226352606-226352607(-) m6A CDS       24209618//27773535
chr1:226353607-226353608(-) m6A CDS       24209618//27773535
chr1:226374311-226374312(-) m6A CDS       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ACBD3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: ACBD3

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-3 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.

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