Detail Information

Basic Information:


  VIRBase ID:  

VHID00427362

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           POGK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b POGK
miRBase
Accession/Entrez ID		 MIMAT0002180 57645
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - BASS2//KRBOX2//LST003

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR POGK
chr1:166825342(+) A-I      3'UTR
chr1:166825294(+) A-I      3'UTR
chr1:166825465(+) A-I      3'UTR
chr1:166825333(+) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase POGK
chr1:166808693-166808694(+) m6A 5'UTR       24981863
chr1:166809643-166809644(+) m6A 5'UTR//intron       -
chr1:166809655-166809656(+) m6A 5'UTR//intron       -
chr1:166809660-166809661(+) m6A 5'UTR//intron       -
chr1:166810248-166810249(+) m1A CDS       26863196
chr1:166810267-166810268(+) m6A CDS       24981863
chr1:166810287-166810288(+) m6A CDS       -
chr1:166816751-166816752(+) m6A CDS       24284625
chr1:166818204-166818205(+) m6A CDS       24284625
chr1:166818213-166818214(+) m6A CDS       24284625//22575960
chr1:166818513-166818514(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818603-166818604(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818648-166818649(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818705-166818706(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818816-166818817(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818829-166818830(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166818983-166818984(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819000-166819001(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819073-166819074(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166819146-166819147(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819158-166819159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819187-166819188(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819263-166819264(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819281-166819282(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819404-166819405(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166819600-166819601(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166819716-166819717(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085
chr1:166819809-166819810(+) m6A 3'UTR//intron       24981863
chr1:166819836-166819837(+) m6A 3'UTR//intron       24284625//24981863
chr1:166819938-166819939(+) m6A 3'UTR//intron       24284625//24981863//22575960
chr1:166819950-166819951(+) m6A 3'UTR//intron       24284625//24981863//22575960
chr1:166820009-166820010(+) m6A 3'UTR//intron       24284625//24981863
chr1:166820086-166820087(+) m6A 3'UTR//intron       24284625//24981863
chr1:166820115-166820116(+) m6A 3'UTR//intron       24284625//24981863
chr1:166820724-166820725(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr1:166820743-166820744(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr1:166820784-166820785(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr1:166820824-166820825(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr1:166820897-166820898(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr1:166820910-166820911(+) m6A 3'UTR//intron       24981863//22608085
chr1:166821829-166821830(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085
chr1:166821841-166821842(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166821908-166821909(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166821936-166821937(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166821951-166821952(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr1:166821977-166821978(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166822027-166822028(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166822046-166822047(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166822063-166822064(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:166822119-166822120(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:166822137-166822138(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:166822162-166822163(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:166822187-166822188(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:166822230-166822231(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr1:166822278-166822279(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr1:166822301-166822302(+) m6A 3'UTR       24284625//24981863//26404942//22575960//22608085
chr1:166823413-166823414(+) Y 3'UTR       25219674//26075521
chr1:166823498-166823499(+) m6A 3'UTR       24284625//24981863//26404942//22608085
chr1:166823672-166823673(+) m6A 3'UTR       24981863//27773535//22608085
chr1:166823689-166823690(+) m6A 3'UTR       24981863//27773535//22608085
chr1:166823704-166823705(+) m6A 3'UTR       24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate POGK
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: POGK

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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