Detail Information

Basic Information:


  VIRBase ID:  

VHID00427332

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           MTUS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b MTUS1
miRBase
Accession/Entrez ID		 MIMAT0002180 57509
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ATBP//ATIP//ATIP3//ICIS//MP44//MTSG1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MTUS1
chr8:17539927(-) A-I      intronic
chr8:17655872(-) A-I      intronic
chr8:17654429(-) A-I      intronic
chr8:17654428(-) A-I      intronic
chr8:17648279(-) A-I      intronic
chr8:17643603(-) A-I      intronic
chr8:17643566(-) A-I      intronic
chr8:17643549(-) A-I      intronic
chr8:17643479(-) A-I      intronic
chr8:17513999(-) A-I      intronic
chr8:17601984(-) A-I      intronic
chr8:17562629(-) A-I      intronic
chr8:17515643(-) A-I      intronic
chr8:17528249(-) A-I      intronic
chr8:17537190(-) A-I      intronic
chr8:17562603(-) A-I      intronic
chr8:17562585(-) A-I      intronic
chr8:17556884(-) A-I      intronic
chr8:17551673(-) A-I      intronic
chr8:17539993(-) A-I      intronic
chr8:17539989(-) A-I      intronic
chr8:17539964(-) A-I      intronic
chr8:17539853(-) A-I      intronic
chr8:17646706(-) A-I      intronic
chr8:17567896(-) A-I      intronic
chr8:17567897(-) A-I      intronic
chr8:17567898(-) A-I      intronic
chr8:17567927(-) A-I      intronic
chr8:17567930(-) A-I      intronic
chr8:17567940(-) A-I      intronic
chr8:17567943(-) A-I      intronic
chr8:17528183(-) A-I      intronic
chr8:17528222(-) A-I      intronic
chr8:17528160(-) A-I      intronic
chr8:17528220(-) A-I      intronic
chr8:17528246(-) A-I      intronic
chr8:17648309(-) A-I      intronic
chr8:17648292(-) A-I      intronic
chr8:17648270(-) A-I      intronic
chr8:17537071(-) A-I      intronic
chr8:17531737(-) A-I      intronic
chr8:17620683(-) A-I      intronic
chr8:17646702(-) A-I      intronic
chr8:17640543(-) A-I      intronic
chr8:17640421(-) A-I      intronic
chr8:17567327(-) A-I      intronic
chr8:17539915(-) A-I      intronic
chr8:17537927(-) A-I      intronic
chr8:17517038(-) A-I      intronic
chr8:17620719(-) A-I      intronic
chr8:17620702(-) A-I      intronic
chr8:17620694(-) A-I      intronic
chr8:17556861(-) A-I      intronic
chr8:17556838(-) A-I      intronic
chr8:17556835(-) A-I      intronic
chr8:17556829(-) A-I      intronic
chr8:17556824(-) A-I      intronic
chr8:17556823(-) A-I      intronic
chr8:17531702(-) A-I      intronic
chr8:17537228(-) A-I      intronic
chr8:17531125(-) A-I      intronic
chr8:17556812(-) A-I      intronic
chr8:17539845(-) A-I      intronic
chr8:17537078(-) A-I      intronic
chr8:17537079(-) A-I      intronic
chr8:17537188(-) A-I      intronic
chr8:17537189(-) A-I      intronic
chr8:17537710(-) A-I      intronic
chr8:17537770(-) A-I      intronic
chr8:17537205(-) A-I      intronic
chr8:17538481(-) A-I      intronic
chr8:17538511(-) A-I      intronic
chr8:17538724(-) A-I      intronic
chr8:17539808(-) A-I      intronic
chr8:17539833(-) A-I      intronic
chr8:17655953(-) A-I      intronic
chr8:17648427(-) A-I      intronic
chr8:17654569(-) A-I      intronic
chr8:17654611(-) A-I      intronic
chr8:17521229(-) A-I      intronic
chr8:17521216(-) A-I      intronic
chr8:17515724(-) A-I      intronic
chr8:17515719(-) A-I      intronic
chr8:17515685(-) A-I      intronic
chr8:17515675(-) A-I      intronic
chr8:17515623(-) A-I      intronic
chr8:17514419(-) A-I      intronic
chr8:17515789(-) A-I      intronic
chr8:17656113(-) A-I      intronic
chr8:17551912(-) A-I      intronic
chr8:17537191(-) A-I      intronic
chr8:17537800(-) A-I      intronic
chr8:17556852(-) A-I      intronic
chr8:17515713(-) A-I      intronic
chr8:17577643(-) A-I      intronic
chr8:17515253(-) A-I      intronic
chr8:17531763(-) A-I      intronic
chr8:17531146(-) A-I      intronic
chr8:17539862(-) A-I      intronic
chr8:17531160(-) A-I      intronic
chr8:17538571(-) A-I      intronic
chr8:17531690(-) A-I      intronic
chr8:17531781(-) A-I      intronic
chr8:17537793(-) A-I      intronic
chr8:17531120(-) A-I      intronic
chr8:17537149(-) A-I      intronic
chr8:17517637(-) A-I      intronic
chr8:17514401(-) A-I      intronic
chr8:17508107(-) A-I      intronic
chr8:17537728(-) A-I      intronic
chr8:17538722(-) A-I      intronic
chr8:17569942(-) A-I      intronic
chr8:17598438(-) A-I      intronic
chr8:17513974(-) A-I      intronic
chr8:17587806(-) A-I      intronic
chr8:17515741(-) A-I      intronic
chr8:17551681(-) A-I      intronic
chr8:17538694(-) A-I      intronic
chr8:17539917(-) A-I      intronic
chr8:17537810(-) A-I      intronic
chr8:17537729(-) A-I      intronic
chr8:17541044(-) A-I      intronic
chr8:17515714(-) A-I      intronic
chr8:17531231(-) A-I      intronic
chr8:17560986(-) A-I      intronic
chr8:17531068(-) A-I      intronic
chr8:17596600(-) A-I      intronic
chr8:17595178(-) A-I      intronic
chr8:17515780(-) A-I      intronic
chr8:17569970(-) A-I      intronic
chr8:17515694(-) A-I      intronic
chr8:17538497(-) A-I      intronic
chr8:17513977(-) A-I      intronic
chr8:17531236(-) A-I      intronic
chr8:17539879(-) A-I      intronic
chr8:17540767(-) A-I      intronic
chr8:17537284(-) A-I      intronic
chr8:17513857(-) A-I      intronic
chr8:17540592(-) A-I      intronic
chr8:17537807(-) A-I      intronic
chr8:17599724(-) A-I      intronic
chr8:17515671(-) A-I      intronic
chr8:17528184(-) A-I      intronic
chr8:17537285(-) A-I      intronic
chr8:17538581(-) A-I      intronic
chr8:17537184(-) A-I      intronic
chr8:17538636(-) A-I      intronic
chr8:17515723(-) A-I      intronic
chr8:17531250(-) A-I      intronic
chr8:17539768(-) A-I      intronic
chr8:17506703(-) A-I      intronic
chr8:17538575(-) A-I      intronic
chr8:17531817(-) A-I      intronic
chr8:17515765(-) A-I      intronic
chr8:17617715(-) A-I      intronic
chr8:17541056(-) A-I      intronic
chr8:17531846(-) A-I      intronic
chr8:17539859(-) A-I      intronic
chr8:17538639(-) A-I      intronic
chr8:17513925(-) A-I      intronic
chr8:17595164(-) A-I      intronic
chr8:17538559(-) A-I      intronic
chr8:17531245(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MTUS1
chr8:17501477-17501478(-) m6A 3'UTR//exon       26404942
chr8:17501496-17501497(-) m6A 3'UTR//exon       26404942
chr8:17501519-17501520(-) m6A 3'UTR//exon       26404942
chr8:17501969-17501970(-) m6A 3'UTR//exon       26404942
chr8:17502249-17502250(-) m6A 3'UTR//exon       26404942
chr8:17502306-17502307(-) m6A 3'UTR//exon       24981863//26404942
chr8:17502322-17502323(-) m6A 3'UTR//exon       24981863//26404942
chr8:17502384-17502385(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr8:17502415-17502416(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr8:17502583-17502584(-) m6A 3'UTR//exon       27773535
chr8:17502605-17502606(-) m6A 3'UTR//exon       27773535
chr8:17502693-17502694(-) m6A 3'UTR//exon       27773535
chr8:17503063-17503064(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17503115-17503116(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17503257-17503258(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503270-17503271(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503276-17503277(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503379-17503380(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503413-17503414(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503534-17503535(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503548-17503549(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17504511-17504512(-) m6A 3'UTR//CDS//exon       27773535
chr8:17504583-17504584(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507357-17507358(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507382-17507383(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507396-17507397(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507444-17507445(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17509117-17509118(-) m6A exon//intron       24981863//27773535
chr8:17509270-17509271(-) m6A exon//intron       24981863//27773535
chr8:17510727-17510728(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17512022-17512023(-) m6A exon//intron       24981863
chr8:17512042-17512043(-) m6A exon//intron       24981863
chr8:17512109-17512110(-) m6A 3'UTR//CDS//exon       24981863
chr8:17513420-17513421(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17513478-17513479(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17513520-17513521(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17521549-17521550(-) m6A exon//intron       27773535
chr8:17521567-17521568(-) m6A exon//intron       27773535
chr8:17541933-17541934(-) m6A 3'UTR//CDS//exon       26404942
chr8:17541946-17541947(-) m6A 3'UTR//CDS//exon       26404942
chr8:17541970-17541971(-) m6A 3'UTR//CDS//exon       26404942
chr8:17542000-17542001(-) m6A 3'UTR//CDS//exon       26404942
chr8:17548850-17548851(-) m6A exon//intron       27773535
chr8:17549503-17549504(-) m6A exon//intron       27773535
chr8:17554887-17554888(-) m6A 5'UTR//intron       -
chr8:17554948-17554949(-) m6A 5'UTR//intron       24981863
chr8:17555070-17555071(-) m6A 5'UTR//intron       -
chr8:17555146-17555147(-) m6A 5'UTR//intron       -
chr8:17566319-17566320(-) m6A exon//intron       -
chr8:17601183-17601184(-) m6A CDS//exon       27773535
chr8:17601292-17601293(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611251-17611252(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611270-17611271(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611282-17611283(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611296-17611297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611437-17611438(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611506-17611507(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611573-17611574(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611596-17611597(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611625-17611626(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611650-17611651(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611665-17611666(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611672-17611673(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611707-17611708(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611717-17611718(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611799-17611800(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611804-17611805(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611827-17611828(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611888-17611889(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611898-17611899(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611919-17611920(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611928-17611929(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17612014-17612015(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612048-17612049(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612086-17612087(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612110-17612111(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612154-17612155(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612189-17612190(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612196-17612197(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612219-17612220(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612298-17612299(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr8:17612353-17612354(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr8:17612451-17612452(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612470-17612471(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612597-17612598(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612627-17612628(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612655-17612656(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612691-17612692(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612838-17612839(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17612843-17612844(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17612876-17612877(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17613138-17613139(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613182-17613183(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613203-17613204(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613270-17613271(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613392-17613393(-) m6A 5'UTR//exon       24284625//24981863//27773535//22608085
chr8:17613396-17613397(-) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr8:17613405-17613406(-) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr8:17613426-17613427(-) m6A 5'UTR//exon       24981863//26404942//27773535
chr8:17613433-17613434(-) m6A 5'UTR//exon       24981863//26404942//27773535
chr8:17613466-17613467(-) m6A 5'UTR//exon       24981863
chr8:17658300-17658301(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MTUS1
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: MTUS1

Evidence Support:


Strong-Evidence 3'UTR indicator assay
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase

References:


PMID 23170179 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression Downregulation
Description Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP) (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays.

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