Basic Information:

  VIRBase ID:  

VHID00427235

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          KBTBD4:  NM_001318719     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	KBTBD4
miRBase Accession/Entrez ID	MIMAT0002180	55709
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BKLHD4//HSPC252

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KBTBD4	chr11:47594202-47594203(-) m6A 3'UTR       27773535 chr11:47594596-47594597(-) m6A CDS       24284625//24209618 chr11:47594692-47594693(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr11:47594722-47594723(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr11:47594819-47594820(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:47594853-47594854(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:47594866-47594867(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:47594957-47594958(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:47594963-47594964(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:47595023-47595024(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr11:47595088-47595089(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:47595181-47595182(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:47595226-47595227(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr11:47599114-47599115(-) m6A 3'UTR//CDS       24284625//22608085 chr11:47599183-47599184(-) m6A 3'UTR//CDS       24284625//24981863//27371828//22608085 chr11:47599224-47599225(-) m6A 3'UTR//CDS       24284625//24981863//22608085 chr11:47599232-47599233(-) m6A 3'UTR//CDS       24284625//24981863//22608085 chr11:47599443-47599444(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:47599486-47599487(-) Am 3'UTR//CDS       - chr11:47599498-47599499(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:47599510-47599511(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:47599579-47599580(-) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:47599628-47599629(-) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:47599644-47599645(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22608085 chr11:47599687-47599688(-) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr11:47599703-47599704(-) m6A 5'UTR//intron       22608085 chr11:47599723-47599724(-) m6A 5'UTR//intron       22608085 chr11:47600086-47600087(-) m6A 5'UTR//intron       25456834 chr11:47600173-47600174(-) m6A 5'UTR//CDS//intron       25456834//24981863 chr11:47600224-47600225(-) m6A 5'UTR//intron       25456834 chr11:47600387-47600388(-) m6A 5'UTR//intron       24981863 chr11:47600470-47600471(-) m6A 5'UTR//intron       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	KBTBD4	Exosome Blood     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: KBTBD4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.