Basic Information:

  VIRBase ID:  

VHID00427131

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          CYCS:  NM_018947     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	CYCS
miRBase Accession/Entrez ID	MIMAT0002180	54205
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CYC//HCS//THC4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CYCS	chr7:25159909(-) A-I      3'UTR chr7:25159937(-) A-I      3'UTR chr7:25160920(-) A-I      3'UTR chr7:25161459(-) A-I      3'UTR chr7:25159176(-) A-I      3'UTR chr7:25159225(-) A-I      3'UTR chr7:25159312(-) A-I      3'UTR chr7:25161540(-) A-I      3'UTR chr7:25161470(-) A-I      3'UTR chr7:25161438(-) A-I      3'UTR chr7:25161370(-) A-I      3'UTR chr7:25161034(-) A-I      3'UTR chr7:25161013(-) A-I      3'UTR chr7:25159098(-) A-I      3'UTR chr7:25160740(-) A-I      3'UTR chr7:25160561(-) A-I      3'UTR chr7:25159969(-) A-I      3'UTR chr7:25159906(-) A-I      3'UTR chr7:25160634(-) A-I      3'UTR chr7:25160667(-) A-I      3'UTR chr7:25160934(-) A-I      3'UTR chr7:25160950(-) A-I      3'UTR chr7:25159338(-) A-I      3'UTR chr7:25159752(-) A-I      3'UTR chr7:25159811(-) A-I      3'UTR chr7:25159814(-) A-I      3'UTR chr7:25159849(-) A-I      3'UTR chr7:25159883(-) A-I      3'UTR chr7:25160681(-) A-I      3'UTR chr7:25159884(-) A-I      3'UTR chr7:25159885(-) A-I      3'UTR chr7:25159137(-) A-I      3'UTR chr7:25159132(-) A-I      3'UTR chr7:25159113(-) A-I      3'UTR chr7:25159099(-) A-I      3'UTR chr7:25159077(-) A-I      3'UTR chr7:25158968(-) A-I      3'UTR chr7:25158906(-) A-I      3'UTR chr7:25159141(-) A-I      3'UTR chr7:25159162(-) A-I      3'UTR chr7:25158993(-) A-I      3'UTR chr7:25159004(-) A-I      3'UTR chr7:25159028(-) A-I      3'UTR chr7:25159089(-) A-I      3'UTR chr7:25159127(-) A-I      3'UTR chr7:25159145(-) A-I      3'UTR chr7:25159159(-) A-I      3'UTR chr7:25159200(-) A-I      3'UTR chr7:25159201(-) A-I      3'UTR chr7:25159770(-) A-I      3'UTR chr7:25159777(-) A-I      3'UTR chr7:25159788(-) A-I      3'UTR chr7:25159820(-) A-I      3'UTR chr7:25159874(-) A-I      3'UTR chr7:25159887(-) A-I      3'UTR chr7:25159168(-) A-I      3'UTR chr7:25158934(-) A-I      3'UTR chr7:25161484(-) A-I      3'UTR chr7:25161124(-) A-I      3'UTR chr7:25159332(-) A-I      3'UTR chr7:25159873(-) A-I      3'UTR chr7:25159122(-) A-I      3'UTR chr7:25160478(-) A-I      3'UTR chr7:25159801(-) A-I      3'UTR chr7:25160499(-) A-I      3'UTR chr7:25159063(-) A-I      3'UTR chr7:25159024(-) A-I      3'UTR chr7:25161040(-) A-I      3'UTR chr7:25160919(-) A-I      3'UTR chr7:25160578(-) A-I      3'UTR chr7:25161385(-) A-I      3'UTR chr7:25161411(-) A-I      3'UTR chr7:25160581(-) A-I      3'UTR chr7:25160471(-) A-I      3'UTR chr7:25159872(-) A-I      3'UTR chr7:25160618(-) A-I      3'UTR chr7:25159977(-) A-I      3'UTR chr7:25161349(-) A-I      3'UTR chr7:25159942(-) A-I      3'UTR chr7:25161402(-) A-I      3'UTR chr7:25159951(-) A-I      3'UTR chr7:25161360(-) A-I      3'UTR chr7:25159735(-) A-I      3'UTR chr7:25159001(-) A-I      3'UTR chr7:25158972(-) A-I      3'UTR chr7:25159772(-) A-I      3'UTR chr7:25159017(-) A-I      3'UTR chr7:25159072(-) A-I      3'UTR chr7:25161446(-) A-I      3'UTR chr7:25159880(-) A-I      3'UTR chr7:25159843(-) A-I      3'UTR chr7:25159947(-) A-I      3'UTR chr7:25160913(-) A-I      3'UTR chr7:25161303(-) A-I      3'UTR chr7:25161304(-) A-I      3'UTR chr7:25159972(-) A-I      3'UTR chr7:25159059(-) A-I      3'UTR chr7:25161437(-) A-I      3'UTR chr7:25161080(-) A-I      3'UTR chr7:25160631(-) A-I      3'UTR chr7:25159918(-) A-I      3'UTR chr7:25159108(-) A-I      3'UTR chr7:25159074(-) A-I      3'UTR chr7:25161014(-) A-I      3'UTR chr7:25160522(-) A-I      3'UTR chr7:25159733(-) A-I      3'UTR chr7:25160970(-) A-I      3'UTR chr7:25159277(-) A-I      3'UTR chr7:25158992(-) A-I      3'UTR chr7:25159955(-) A-I      3'UTR chr7:25160680(-) A-I      3'UTR chr7:25161387(-) A-I      3'UTR chr7:25159065(-) A-I      3'UTR chr7:25161322(-) A-I      3'UTR chr7:25158964(-) A-I      3'UTR chr7:25161508(-) A-I      3'UTR chr7:25159040(-) A-I      3'UTR chr7:25159083(-) A-I      3'UTR chr7:25160735(-) A-I      3'UTR chr7:25160527(-) A-I      3'UTR chr7:25159011(-) A-I      3'UTR chr7:25160500(-) A-I      3'UTR chr7:25159842(-) A-I      3'UTR chr7:25161119(-) A-I      3'UTR chr7:25158963(-) A-I      3'UTR chr7:25159932(-) A-I      3'UTR chr7:25159921(-) A-I      3'UTR chr7:25160572(-) A-I      3'UTR chr7:25161086(-) A-I      3'UTR chr7:25161335(-) A-I      3'UTR chr7:25159781(-) A-I      3'UTR chr7:25159073(-) A-I      3'UTR chr7:25160656(-) A-I      3'UTR chr7:25159088(-) A-I      3'UTR chr7:25161050(-) A-I      3'UTR chr7:25160660(-) A-I      3'UTR chr7:25160938(-) A-I      3'UTR chr7:25159881(-) A-I      3'UTR chr7:25161331(-) A-I      3'UTR chr7:25159833(-) A-I      3'UTR chr7:25161520(-) A-I      3'UTR chr7:25161477(-) A-I      3'UTR chr7:25161424(-) A-I      3'UTR chr7:25160982(-) A-I      3'UTR chr7:25159875(-) A-I      3'UTR chr7:25161398(-) A-I      3'UTR chr7:25160487(-) A-I      3'UTR chr7:25161422(-) A-I      3'UTR chr7:25161291(-) A-I      3'UTR chr7:25159882(-) A-I      3'UTR chr7:25161499(-) A-I      3'UTR chr7:25159002(-) A-I      3'UTR chr7:25159071(-) A-I      3'UTR chr7:25159898(-) A-I      3'UTR chr7:25160704(-) A-I      3'UTR chr7:25160905(-) A-I      3'UTR chr7:25159996(-) A-I      3'UTR chr7:25160686(-) A-I      3'UTR chr7:25161463(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CYCS	chr7:25159290(-) A-I exon 3'UTR    15342557 chr7:25159772(-) A-I exon 3'UTR    15342557 chr7:25159781(-) A-I exon 3'UTR    15342557 chr7:25159807(-) A-I exon 3'UTR    15342557 chr7:25159810(-) A-I exon 3'UTR    15342557 chr7:25159842(-) A-I exon 3'UTR    15342557 chr7:25159843(-) A-I exon 3'UTR    15342557 chr7:25159865(-) A-I exon 3'UTR    15342557 chr7:25159872(-) A-I exon 3'UTR    15342557 chr7:25159873(-) A-I exon 3'UTR    15342557 chr7:25159932(-) A-I exon 3'UTR    15342557   //15258596 chr7:25159947(-) A-I exon 3'UTR    15342557   //15258596 chr7:25159956(-) A-I exon 3'UTR    15258596 chr7:25159977(-) A-I exon 3'UTR    15342557   //15258596 chr7:25159978(-) A-I exon 3'UTR    15342557   //15258596 chr7:25160004(-) A-I exon 3'UTR    15342557 chr7:25160518(-) A-I exon 3'UTR    15342557 chr7:25160527(-) A-I exon 3'UTR    15342557 chr7:25160599(-) A-I exon 3'UTR    15342557 chr7:25160621(-) A-I exon 3'UTR    15342557 chr7:25160631(-) A-I exon 3'UTR    15342557 chr7:25160730(-) A-I exon 3'UTR    15342557   //21960545 chr7:25160735(-) A-I exon 3'UTR    15342557   //21960545 chr7:25161040(-) A-I exon 3'UTR    15342557 chr7:25161291(-) A-I exon 3'UTR    15342557 chr7:25161422(-) A-I exon 3'UTR    15342557 chr7:25161424(-) A-I exon 3'UTR    15342557   //21960545 chr7:25161483(-) A-I exon 3'UTR    15342557 chr7:25160660(-) A-I exon 3'UTR    21960545   //22327324 chr7:25160661(-) A-I exon 3'UTR    22327324 chr7:25160907(-) A-I exon 3'UTR    21960545 chr7:25160913(-) A-I exon 3'UTR    21960545 chr7:25161424(-) A-G exon 3'UTR    21725310 chr7:25159181(-) A-G exon 3'UTR    22484847 chr7:25159781(-) A-G exon 3'UTR    22484847 chr7:25159807(-) A-G exon 3'UTR    22484847 chr7:25159810(-) A-G exon 3'UTR    22484847 chr7:25159842(-) A-G exon 3'UTR    22484847 chr7:25159872(-) A-G exon 3'UTR    22484847 chr7:25159873(-) A-G exon 3'UTR    22484847 chr7:25159908(-) A-G exon 3'UTR    22484847 chr7:25159932(-) A-G exon 3'UTR    22484847 chr7:25159947(-) A-G exon 3'UTR    22484847 chr7:25159956(-) A-G exon 3'UTR    22484847 chr7:25159977(-) A-G exon 3'UTR    22484847 chr7:25159978(-) A-G exon 3'UTR    22484847 chr7:25159986(-) A-G exon 3'UTR    22484847 chr7:25159996(-) A-G exon 3'UTR    22484847 chr7:25160487(-) A-G exon 3'UTR    22484847 chr7:25160499(-) A-G exon 3'UTR    22484847 chr7:25160500(-) A-G exon 3'UTR    22484847 chr7:25160518(-) A-G exon 3'UTR    22484847 chr7:25160527(-) A-G exon 3'UTR    22484847 chr7:25160581(-) A-G exon 3'UTR    22484847 chr7:25160631(-) A-G exon 3'UTR    22484847 chr7:25160660(-) A-G exon 3'UTR    22484847 chr7:25160661(-) A-G exon 3'UTR    22484847 chr7:25160686(-) A-G exon 3'UTR    22484847 chr7:25160735(-) A-G exon 3'UTR    22484847 chr7:25161040(-) A-G exon 3'UTR    22484847 chr7:25161483(-) A-G exon 3'UTR    22484847 chr7:25161484(-) A-G exon 3'UTR    22484847 chr7:25160004(-) A-G exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CYCS	chr7:25160373-25160374(-) m6A 3'UTR       27773535 chr7:25160437-25160438(-) m6A 3'UTR       27773535 chr7:25161995-25161996(-) m6A 3'UTR       27773535 chr7:25162006-25162007(-) m6A 3'UTR       27773535 chr7:25162022-25162023(-) m6A 3'UTR       27773535 chr7:25162208-25162209(-) m6A 3'UTR       27773535 chr7:25162214-25162215(-) m6A 3'UTR       27773535 chr7:25162233-25162234(-) m6A 3'UTR       27773535 chr7:25162457-25162458(-) m6A 3'UTR       24981863//27773535 chr7:25162479-25162480(-) m6A 3'UTR       24981863//27773535 chr7:25162574-25162575(-) m6A 3'UTR       27773535 chr7:25162582-25162583(-) m6A 3'UTR       27773535 chr7:25162587-25162588(-) m6A 3'UTR       27773535 chr7:25162601-25162602(-) m6A 3'UTR       27773535 chr7:25162630-25162631(-) m6A 3'UTR       27773535 chr7:25162664-25162665(-) m6A 3'UTR       27773535 chr7:25163289-25163290(-) m6A 3'UTR       27773535 chr7:25163356-25163357(-) m6A CDS       24981863//27773535 chr7:25163402-25163403(-) m6A CDS       24981863//27773535 chr7:25163574-25163575(-) m6A CDS       24209618//24981863//27773535 chr7:25163617-25163618(-) m6A CDS       24209618//24981863//27773535 chr7:25163653-25163654(-) m6A CDS       24209618//24981863//27773535//22575960//22608085 chr7:25164352-25164353(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr7:25164667-25164668(-) m6A 5'UTR//intron       27773535 chr7:25164678-25164679(-) m6A 5'UTR//intron       27773535 chr7:25164685-25164686(-) m6A 5'UTR//intron       27773535 chr7:25164743-25164744(-) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:25164882-25164883(-) m6A 5'UTR       24284625//24209618//24981863//22608085 chr7:25164898-25164899(-) m6A 5'UTR       24284625//24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CYCS	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: CYCS

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.