Basic Information:

  VIRBase ID:  

VHID00427070

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          TMED7:  NM_181836     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	TMED7
miRBase Accession/Entrez ID	MIMAT0002180	51014
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-109//p24g3//p24gamma3//p27

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMED7	chr5:114950536-114950537(-) m6A 3'UTR       26404942 chr5:114951186-114951187(-) m6A 3'UTR       26404942//27773535 chr5:114951224-114951225(-) m6A 3'UTR       26404942//27773535 chr5:114951273-114951274(-) m6A 3'UTR       27773535 chr5:114951319-114951320(-) m6A 3'UTR       27773535 chr5:114951347-114951348(-) m6A 3'UTR       27773535 chr5:114951474-114951475(-) m6A 3'UTR       27773535 chr5:114951488-114951489(-) m6A 3'UTR       27773535 chr5:114951545-114951546(-) Y 3'UTR       25219674 chr5:114951554-114951555(-) m6A 3'UTR       27773535 chr5:114951588-114951589(-) m6A 3'UTR       24981863//26404942//27773535 chr5:114951622-114951623(-) m6A 3'UTR       24209618//24981863//26404942//27773535//22608085 chr5:114951708-114951709(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951716-114951717(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951746-114951747(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951758-114951759(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951831-114951832(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114951931-114951932(-) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr5:114952084-114952085(-) m6A CDS//exon       24284625//24981863//26404942 chr5:114956153-114956154(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:114956177-114956178(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956208-114956209(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956256-114956257(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:114956296-114956297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085 chr5:114961334-114961335(-) m6A CDS//intron       24284625//27773535 chr5:114961399-114961400(-) m6A CDS//intron       27773536 chr5:114961539-114961540(-) m6A 5'UTR//intron       27773536//22575960 chr5:114961609-114961610(-) m6A 5'UTR//exon       24284625//24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TMED7	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: TMED7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.