Basic Information:

  VIRBase ID:  

VHID00427069

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          EXOSC1:  NR_134586     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	EXOSC1
miRBase Accession/Entrez ID	MIMAT0002180	51013
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CGI-108//CSL4//Csl4p//p13//SKI4//Ski4p

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EXOSC1	chr10:99197947(-) A-I      intronic chr10:99203618(-) A-I      ncRNA chr10:99203592(-) A-I      ncRNA chr10:99203626(-) A-I      ncRNA chr10:99201364(-) A-I      intronic chr10:99196598(-) A-I      intronic chr10:99201888(-) A-I      intronic chr10:99196641(-) A-I      intronic chr10:99201340(-) A-I      intronic chr10:99196711(-) A-I      intronic chr10:99201913(-) A-I      intronic chr10:99201404(-) A-I      intronic chr10:99201909(-) A-I      intronic chr10:99201313(-) A-I      intronic chr10:99196624(-) A-I      intronic chr10:99202543(-) A-I      intronic chr10:99201350(-) A-I      intronic chr10:99202784(-) A-I      intronic chr10:99201316(-) A-I      intronic chr10:99200390(-) A-I      intronic chr10:99197356(-) A-I      intronic chr10:99198585(-) A-I      intronic chr10:99202617(-) A-I      intronic chr10:99201716(-) A-I      intronic chr10:99197269(-) A-I      intronic chr10:99201891(-) A-I      intronic chr10:99202631(-) A-I      intronic chr10:99197737(-) A-I      intronic chr10:99201771(-) A-I      intronic chr10:99201768(-) A-I      intronic chr10:99196759(-) A-I      intronic chr10:99196704(-) A-I      intronic chr10:99196632(-) A-I      intronic chr10:99200413(-) A-I      intronic chr10:99196618(-) A-I      intronic chr10:99196609(-) A-I      intronic chr10:99201785(-) A-I      intronic chr10:99195683(-) A-I      3'UTR chr10:99203665(-) A-I      ncRNA chr10:99196735(-) A-I      intronic chr10:99202380(-) A-I      intronic chr10:99197946(-) A-I      intronic chr10:99196672(-) A-I      intronic chr10:99202535(-) A-I      intronic chr10:99196686(-) A-I      intronic chr10:99201851(-) A-I      intronic chr10:99200123(-) A-I      intronic chr10:99196673(-) A-I      intronic chr10:99196633(-) A-I      intronic chr10:99202546(-) A-I      intronic chr10:99196524(-) A-I      intronic chr10:99196659(-) A-I      intronic chr10:99203295(-) A-I      intronic chr10:99196713(-) A-I      intronic chr10:99202690(-) A-I      intronic chr10:99202616(-) A-I      intronic chr10:99202801(-) A-I      intronic chr10:99201412(-) A-I      intronic chr10:99202597(-) A-I      intronic chr10:99201786(-) A-I      intronic chr10:99201766(-) A-I      intronic chr10:99203313(-) A-I      intronic chr10:99201812(-) A-I      intronic chr10:99201878(-) A-I      intronic chr10:99203322(-) A-I      intronic chr10:99202549(-) A-I      intronic chr10:99201450(-) A-I      intronic chr10:99201372(-) A-I      intronic chr10:99198646(-) A-I      intronic chr10:99202575(-) A-I      intronic chr10:99201852(-) A-I      intronic chr10:99196687(-) A-I      intronic chr10:99201440(-) A-I      intronic chr10:99201742(-) A-I      intronic chr10:99201929(-) A-I      intronic chr10:99196669(-) A-I      intronic chr10:99202809(-) A-I      intronic chr10:99202799(-) A-I      intronic chr10:99202534(-) A-I      intronic chr10:99202358(-) A-I      intronic chr10:99202314(-) A-I      intronic chr10:99202566(-) A-I      intronic chr10:99201822(-) A-I      intronic chr10:99201118(-) A-I      intronic chr10:99201121(-) A-I      intronic chr10:99196577(-) A-I      intronic chr10:99201385(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EXOSC1	chr10:99196641(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EXOSC1	chr10:99195915-99195916(-) m6A 3'UTR       27773535 chr10:99195984-99195985(-) m6A 3'UTR       27773535 chr10:99195989-99195990(-) m6A 3'UTR       27773535 chr10:99203892-99203893(-) m6A exon//intron       27773535 chr10:99203956-99203957(-) m6A exon//intron       27773535 chr10:99203988-99203989(-) m6A exon//intron       27773535 chr10:99204101-99204102(-) m6A exon//intron       27773535 chr10:99204247-99204248(-) m6A exon//intron       27773535 chr10:99204262-99204263(-) m6A exon//intron       27773535 chr10:99204823-99204824(-) m6A exon//intron       27773535 chr10:99204834-99204835(-) m6A exon//intron       27773535 chr10:99204894-99204895(-) m6A exon//intron       27773535 chr10:99205753-99205754(-) m6A 5'UTR//CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EXOSC1	Cytosol K562 cells     - Exosome Blood     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: EXOSC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//RNAHybrid//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.