Basic Information:

  VIRBase ID:  

VHID00426812

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          ATG14:  NM_014924     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	ATG14
miRBase Accession/Entrez ID	MIMAT0002180	22863
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATG14L//BARKOR//KIAA0831

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATG14	chr14:55845639(-) A-I      intronic chr14:55860484(-) A-I      intronic chr14:55860487(-) A-I      intronic chr14:55860489(-) A-I      intronic chr14:55858026(-) A-I      intronic chr14:55859267(-) A-I      intronic chr14:55860423(-) A-I      intronic chr14:55860810(-) A-I      intronic chr14:55861018(-) A-I      intronic chr14:55838355(-) A-I      intronic chr14:55860968(-) A-I      intronic chr14:55834353(-) A-I      3'UTR chr14:55835115(-) A-I      3'UTR chr14:55834947(-) A-I      3'UTR chr14:55838341(-) A-I      intronic chr14:55834334(-) A-I      3'UTR chr14:55845653(-) A-I      intronic chr14:55838374(-) A-I      intronic chr14:55838373(-) A-I      intronic chr14:55835114(-) A-I      3'UTR chr14:55835106(-) A-I      3'UTR chr14:55835105(-) A-I      3'UTR chr14:55834954(-) A-I      3'UTR chr14:55834949(-) A-I      3'UTR chr14:55838364(-) A-I      intronic chr14:55860475(-) A-I      intronic chr14:55860969(-) A-I      intronic chr14:55840342(-) A-I      intronic chr14:55840380(-) A-I      intronic chr14:55843820(-) A-I      intronic chr14:55843862(-) A-I      intronic chr14:55843873(-) A-I      intronic chr14:55843965(-) A-I      intronic chr14:55845452(-) A-I      intronic chr14:55845464(-) A-I      intronic chr14:55845556(-) A-I      intronic chr14:55845562(-) A-I      intronic chr14:55845594(-) A-I      intronic chr14:55845601(-) A-I      intronic chr14:55845625(-) A-I      intronic chr14:55845646(-) A-I      intronic chr14:55845663(-) A-I      intronic chr14:55845672(-) A-I      intronic chr14:55845699(-) A-I      intronic chr14:55845725(-) A-I      intronic chr14:55846184(-) A-I      intronic chr14:55846225(-) A-I      intronic chr14:55846237(-) A-I      intronic chr14:55846257(-) A-I      intronic chr14:55846262(-) A-I      intronic chr14:55859116(-) A-I      intronic chr14:55846500(-) A-I      intronic chr14:55846502(-) A-I      intronic chr14:55840360(-) A-I      intronic chr14:55846517(-) A-I      intronic chr14:55846552(-) A-I      intronic chr14:55846568(-) A-I      intronic chr14:55846572(-) A-I      intronic chr14:55846577(-) A-I      intronic chr14:55846603(-) A-I      intronic chr14:55846800(-) A-I      intronic chr14:55846803(-) A-I      intronic chr14:55846842(-) A-I      intronic chr14:55846880(-) A-I      intronic chr14:55846890(-) A-I      intronic chr14:55846892(-) A-I      intronic chr14:55846920(-) A-I      intronic chr14:55846928(-) A-I      intronic chr14:55846935(-) A-I      intronic chr14:55846960(-) A-I      intronic chr14:55850141(-) A-I      intronic chr14:55850160(-) A-I      intronic chr14:55850187(-) A-I      intronic chr14:55850193(-) A-I      intronic chr14:55852238(-) A-I      intronic chr14:55854422(-) A-I      intronic chr14:55854448(-) A-I      intronic chr14:55854459(-) A-I      intronic chr14:55854731(-) A-I      intronic chr14:55860056(-) A-I      intronic chr14:55854755(-) A-I      intronic chr14:55857224(-) A-I      intronic chr14:55857230(-) A-I      intronic chr14:55858029(-) A-I      intronic chr14:55846472(-) A-I      intronic chr14:55858072(-) A-I      intronic chr14:55858082(-) A-I      intronic chr14:55858132(-) A-I      intronic chr14:55858137(-) A-I      intronic chr14:55858168(-) A-I      intronic chr14:55859110(-) A-I      intronic chr14:55859121(-) A-I      intronic chr14:55859131(-) A-I      intronic chr14:55859148(-) A-I      intronic chr14:55859218(-) A-I      intronic chr14:55859245(-) A-I      intronic chr14:55859272(-) A-I      intronic chr14:55859285(-) A-I      intronic chr14:55859304(-) A-I      intronic chr14:55859841(-) A-I      intronic chr14:55859856(-) A-I      intronic chr14:55859906(-) A-I      intronic chr14:55859918(-) A-I      intronic chr14:55859930(-) A-I      intronic chr14:55859935(-) A-I      intronic chr14:55859979(-) A-I      intronic chr14:55859991(-) A-I      intronic chr14:55859981(-) A-I      intronic chr14:55860003(-) A-I      intronic chr14:55860324(-) A-I      intronic chr14:55860340(-) A-I      intronic chr14:55860378(-) A-I      intronic chr14:55860419(-) A-I      intronic chr14:55860466(-) A-I      intronic chr14:55860474(-) A-I      intronic chr14:55860476(-) A-I      intronic chr14:55845669(-) A-I      intronic chr14:55860488(-) A-I      intronic chr14:55860803(-) A-I      intronic chr14:55859932(-) A-I      intronic chr14:55860817(-) A-I      intronic chr14:55860836(-) A-I      intronic chr14:55860849(-) A-I      intronic chr14:55860862(-) A-I      intronic chr14:55846538(-) A-I      intronic chr14:55860871(-) A-I      intronic chr14:55860889(-) A-I      intronic chr14:55860898(-) A-I      intronic chr14:55860918(-) A-I      intronic chr14:55860932(-) A-I      intronic chr14:55860952(-) A-I      intronic chr14:55860957(-) A-I      intronic chr14:55838333(-) A-I      intronic chr14:55860958(-) A-I      intronic chr14:55860990(-) A-I      intronic chr14:55860326(-) A-I      intronic chr14:55846165(-) A-I      intronic chr14:55859910(-) A-I      intronic chr14:55845681(-) A-I      intronic chr14:55846903(-) A-I      intronic chr14:55860401(-) A-I      intronic chr14:55846537(-) A-I      intronic chr14:55860929(-) A-I      intronic chr14:55860995(-) A-I      intronic chr14:55837427(-) A-I      intronic chr14:55837428(-) A-I      intronic chr14:55837487(-) A-I      intronic chr14:55837491(-) A-I      intronic chr14:55837562(-) A-I      intronic chr14:55837563(-) A-I      intronic chr14:55838280(-) A-I      intronic chr14:55838329(-) A-I      intronic chr14:55838349(-) A-I      intronic chr14:55838358(-) A-I      intronic chr14:55838491(-) A-I      intronic chr14:55840207(-) A-I      intronic chr14:55840232(-) A-I      intronic chr14:55840310(-) A-I      intronic chr14:55840315(-) A-I      intronic chr14:55835175(-) A-I      3'UTR chr14:55835132(-) A-I      3'UTR chr14:55835131(-) A-I      3'UTR chr14:55835101(-) A-I      3'UTR chr14:55834415(-) A-I      3'UTR chr14:55835070(-) A-I      3'UTR chr14:55835043(-) A-I      3'UTR chr14:55835011(-) A-I      3'UTR chr14:55834314(-) A-I      3'UTR chr14:55834460(-) A-I      3'UTR chr14:55835170(-) A-I      3'UTR chr14:55835194(-) A-I      3'UTR chr14:55834986(-) A-I      3'UTR chr14:55834977(-) A-I      3'UTR chr14:55834249(-) A-I      3'UTR chr14:55835116(-) A-I      3'UTR chr14:55835075(-) A-I      3'UTR chr14:55834217(-) A-I      3'UTR chr14:55834458(-) A-I      3'UTR chr14:55834976(-) A-I      3'UTR chr14:55835210(-) A-I      3'UTR chr14:55834967(-) A-I      3'UTR chr14:55834953(-) A-I      3'UTR chr14:55834951(-) A-I      3'UTR chr14:55834965(-) A-I      3'UTR chr14:55835024(-) A-I      3'UTR chr14:55834950(-) A-I      3'UTR chr14:55834436(-) A-I      3'UTR chr14:55835117(-) A-I      3'UTR chr14:55834946(-) A-I      3'UTR chr14:55835162(-) A-I      3'UTR chr14:55835156(-) A-I      3'UTR chr14:55835202(-) A-I      3'UTR chr14:55835120(-) A-I      3'UTR chr14:55834399(-) A-I      3'UTR chr14:55834393(-) A-I      3'UTR chr14:55834380(-) A-I      3'UTR chr14:55834945(-) A-I      3'UTR chr14:55835151(-) A-I      3'UTR chr14:55834375(-) A-I      3'UTR chr14:55834350(-) A-I      3'UTR chr14:55835205(-) A-I      3'UTR chr14:55834313(-) A-I      3'UTR chr14:55835211(-) A-I      3'UTR chr14:55834305(-) A-I      3'UTR chr14:55835219(-) A-I      3'UTR chr14:55834297(-) A-I      3'UTR chr14:55835184(-) A-I      3'UTR chr14:55834281(-) A-I      3'UTR chr14:55834278(-) A-I      3'UTR chr14:55834269(-) A-I      3'UTR chr14:55834400(-) A-I      3'UTR chr14:55835233(-) A-I      3'UTR chr14:55834239(-) A-I      3'UTR chr14:55834202(-) A-I      3'UTR chr14:55835141(-) A-I      3'UTR chr14:55835133(-) A-I      3'UTR chr14:55860928(-) A-I      intronic chr14:55849178(-) A-I      intronic chr14:55845479(-) A-I      intronic chr14:55861014(-) A-I      intronic chr14:55846884(-) A-I      intronic chr14:55860329(-) A-I      intronic chr14:55846173(-) A-I      intronic chr14:55846219(-) A-I      intronic chr14:55846866(-) A-I      intronic chr14:55860040(-) A-I      intronic chr14:55860539(-) A-I      intronic chr14:55860467(-) A-I      intronic chr14:55849182(-) A-I      intronic chr14:55858111(-) A-I      intronic chr14:55860101(-) A-I      intronic chr14:55860998(-) A-I      intronic chr14:55860447(-) A-I      intronic chr14:55845552(-) A-I      intronic chr14:55854483(-) A-I      intronic chr14:55859284(-) A-I      intronic chr14:55845604(-) A-I      intronic chr14:55860411(-) A-I      intronic chr14:55861004(-) A-I      intronic chr14:55860414(-) A-I      intronic chr14:55846958(-) A-I      intronic chr14:55860041(-) A-I      intronic chr14:55854484(-) A-I      intronic chr14:55860540(-) A-I      intronic chr14:55834448(-) A-I      3'UTR chr14:55834966(-) A-I      3'UTR chr14:55834216(-) A-I      3'UTR chr14:55834361(-) A-I      3'UTR chr14:55835113(-) A-I      3'UTR chr14:55834318(-) A-I      3'UTR chr14:55835059(-) A-I      3'UTR chr14:55835049(-) A-I      3'UTR chr14:55834300(-) A-I      3'UTR chr14:55835066(-) A-I      3'UTR chr14:55834210(-) A-I      3'UTR chr14:55835104(-) A-I      3'UTR chr14:55835197(-) A-I      3'UTR chr14:55834379(-) A-I      3'UTR chr14:55835108(-) A-I      3'UTR chr14:55834362(-) A-I      3'UTR chr14:55834204(-) A-I      3'UTR chr14:55834218(-) A-I      3'UTR chr14:55834429(-) A-I      3'UTR chr14:55834376(-) A-I      3'UTR chr14:55834295(-) A-I      3'UTR chr14:55834424(-) A-I      3'UTR chr14:55835165(-) A-I      3'UTR chr14:55834418(-) A-I      3'UTR chr14:55835111(-) A-I      3'UTR chr14:55834367(-) A-I      3'UTR chr14:55834296(-) A-I      3'UTR chr14:55834405(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATG14	chr14:55834204(-) A-I exon 3'UTR    15342557 chr14:55834210(-) A-I exon 3'UTR    15342557 chr14:55834216(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834217(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834244(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834249(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834296(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834300(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834361(-) A-I exon 3'UTR    15342557   //22327324 chr14:55834367(-) A-I exon 3'UTR    15342557 chr14:55834376(-) A-I exon 3'UTR    15342557   //22327324 chr14:55834379(-) A-I exon 3'UTR    15342557 chr14:55834405(-) A-I exon 3'UTR    15342557 chr14:55834418(-) A-I exon 3'UTR    15342557 chr14:55834424(-) A-I exon 3'UTR    15342557 chr14:55834448(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834965(-) A-I exon 3'UTR    15342557   //15258596 chr14:55834966(-) A-I exon 3'UTR    15342557   //15258596   //22327324 chr14:55835024(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835049(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835108(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835111(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835113(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835116(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835120(-) A-I exon 3'UTR    15342557   //15258596   //22327324 chr14:55835184(-) A-I exon 3'UTR    15258596 chr14:55835197(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835205(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835227(-) A-I exon 3'UTR    15342557   //15258596 chr14:55835233(-) A-I exon 3'UTR    15342557   //15258596   //22327324 chr14:55845552(-) A-I intron -    22327324 chr14:55845681(-) A-I intron -    22327324 chr14:55860467(-) A-I intron -    22327324 chr14:55860539(-) A-I intron -    22327324 chr14:55860540(-) A-I intron -    22327324 chr14:55860998(-) A-I intron -    22327324 chr14:55834361(-) A-G exon 3'UTR    21725310 chr14:55835120(-) A-G exon 3'UTR    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATG14	chr14:55833145-55833146(-) m6A 3'UTR//exon       27773535 chr14:55833175-55833176(-) m6A 3'UTR//exon       27773535 chr14:55833242-55833243(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:55833284-55833285(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:55833296-55833297(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:55833328-55833329(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:55833383-55833384(-) m6A 3'UTR//exon       27773535 chr14:55833411-55833412(-) m6A 3'UTR//exon       27773535 chr14:55833426-55833427(-) m6A 3'UTR//exon       27773535 chr14:55833446-55833447(-) m6A 3'UTR//exon       27773535 chr14:55835741-55835742(-) m6A 3'UTR//exon       - chr14:55836237-55836238(-) m6A 3'UTR//exon       24981863 chr14:55836270-55836271(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr14:55836320-55836321(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr14:55836326-55836327(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr14:55836345-55836346(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr14:55836505-55836506(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr14:55836514-55836515(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr14:55836530-55836531(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr14:55836563-55836564(-) Gm CDS//exon       - chr14:55836616-55836617(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//22608085 chr14:55844547-55844548(-) m6A CDS//exon       27773535//27371828 chr14:55848783-55848784(-) m6A CDS//exon       27773535 chr14:55852685-55852686(-) m6A CDS//exon       27773535 chr14:55852710-55852711(-) m6A CDS//exon       27773535 chr14:55852793-55852794(-) m6A CDS//exon       24981863//27773535//22608085 chr14:55857661-55857662(-) m6A CDS//exon       24981863//27773535 chr14:55857665-55857666(-) m6A CDS//exon       24981863//27773535//22608085 chr14:55857674-55857675(-) m6A CDS//exon       24981863//27773535//22608085 chr14:55857746-55857747(-) m6A exon//intron       24981863//27773535 chr14:55861795-55861796(-) m6A intron       27773535 chr14:55861809-55861810(-) m6A intron       27773535 chr14:55861870-55861871(-) m6A intron       27773535 chr14:55878457-55878458(-) m6A CDS       24981863//27371828//27773536 chr14:55878466-55878467(-) m6A CDS       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ATG14	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: ATG14

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.