Basic Information:

  VIRBase ID:  

VHID00426784

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          BAZ2A:  NM_001351156     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	BAZ2A
miRBase Accession/Entrez ID	MIMAT0002180	11176
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TIP5//WALp3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BAZ2A	chr12:57001379(-) A-I      intronic chr12:57002877(-) A-I      intronic chr12:57001384(-) A-I      intronic chr12:57001736(-) A-I      intronic chr12:57002857(-) A-I      intronic chr12:57001375(-) A-I      intronic chr12:57013085(-) A-I      intronic chr12:57013047(-) A-I      intronic chr12:57027790(-) A-I      intronic chr12:57014563(-) A-I      intronic chr12:57027789(-) A-I      intronic chr12:57027685(-) A-I      intronic chr12:57027684(-) A-I      intronic chr12:57027589(-) A-I      intronic chr12:57013042(-) A-I      intronic chr12:57013007(-) A-I      intronic chr12:57012759(-) A-I      intronic chr12:57002995(-) A-I      intronic chr12:57019220(-) A-I      intronic chr12:57002913(-) A-I      intronic chr12:57019171(-) A-I      intronic chr12:57019104(-) A-I      intronic chr12:57001782(-) A-I      intronic chr12:57002572(-) A-I      intronic chr12:57001921(-) A-I      intronic chr12:57016933(-) A-I      intronic chr12:57001975(-) A-I      intronic chr12:57015746(-) A-I      intronic chr12:57001992(-) A-I      intronic chr12:57001892(-) A-I      intronic chr12:57018619(-) A-I      intronic chr12:57002021(-) A-I      intronic chr12:57002099(-) A-I      intronic chr12:57001682(-) A-I      intronic chr12:57015605(-) A-I      intronic chr12:57001673(-) A-I      intronic chr12:57013043(-) A-I      intronic chr12:57001699(-) A-I      intronic chr12:57001660(-) A-I      intronic chr12:57001653(-) A-I      intronic chr12:57002585(-) A-I      intronic chr12:57013046(-) A-I      intronic chr12:57002118(-) A-I      intronic chr12:57001630(-) A-I      intronic chr12:57001622(-) A-I      intronic chr12:57002535(-) A-I      intronic chr12:57015575(-) A-I      intronic chr12:57001446(-) A-I      intronic chr12:57016856(-) A-I      intronic chr12:57002414(-) A-I      intronic chr12:57002550(-) A-I      intronic chr12:57002595(-) A-I      intronic chr12:57014568(-) A-I      intronic chr12:57014203(-) A-I      intronic chr12:57001422(-) A-I      intronic chr12:57001334(-) A-I      intronic chr12:57001333(-) A-I      intronic chr12:57002644(-) A-I      intronic chr12:57001777(-) A-I      intronic chr12:57001324(-) A-I      intronic chr12:57015601(-) A-I      intronic chr12:57001284(-) A-I      intronic chr12:57002430(-) A-I      intronic chr12:57014209(-) A-I      intronic chr12:57001261(-) A-I      intronic chr12:57001720(-) A-I      intronic chr12:57019045(-) A-I      intronic chr12:57014166(-) A-I      intronic chr12:57001716(-) A-I      intronic chr12:56996934(-) A-I      intronic chr12:57014416(-) A-I      intronic chr12:57002828(-) A-I      intronic chr12:57002662(-) A-I      intronic chr12:57016839(-) A-I      intronic chr12:57001267(-) A-I      intronic chr12:57002482(-) A-I      intronic chr12:57014564(-) A-I      intronic chr12:57002416(-) A-I      intronic chr12:57019055(-) A-I      intronic chr12:57001745(-) A-I      intronic chr12:57013729(-) A-I      intronic chr12:57001914(-) A-I      intronic chr12:57002868(-) A-I      intronic chr12:57002566(-) A-I      intronic chr12:57002514(-) A-I      intronic chr12:57015747(-) A-I      intronic chr12:57002016(-) A-I      intronic chr12:57014241(-) A-I      intronic chr12:57003103(-) A-I      intronic chr12:57001967(-) A-I      intronic chr12:57002796(-) A-I      intronic chr12:57001361(-) A-I      intronic chr12:57001752(-) A-I      intronic chr12:57018578(-) A-I      intronic chr12:57027687(-) A-I      intronic chr12:57015697(-) A-I      intronic chr12:57002786(-) A-I      intronic chr12:57002822(-) A-I      intronic chr12:57002150(-) A-I      intronic chr12:57001832(-) A-I      intronic chr12:57014199(-) A-I      intronic chr12:57001900(-) A-I      intronic chr12:57019213(-) A-I      intronic chr12:56999311(-) A-I      intronic chr12:57018611(-) A-I      intronic chr12:57027584(-) A-I      intronic chr12:57002142(-) A-I      intronic chr12:57002034(-) A-I      intronic chr12:57002837(-) A-I      intronic chr12:57013621(-) A-I      intronic chr12:57014441(-) A-I      intronic chr12:57001359(-) A-I      intronic chr12:57001764(-) A-I      intronic chr12:57018584(-) A-I      intronic chr12:57001330(-) A-I      intronic chr12:57013210(-) A-I      intronic chr12:57016831(-) A-I      intronic chr12:57003051(-) A-I      intronic chr12:57001389(-) A-I      intronic chr12:57015673(-) A-I      intronic chr12:57001320(-) A-I      intronic chr12:57014371(-) A-I      intronic chr12:57014202(-) A-I      intronic chr12:57016093(-) A-I      intronic chr12:57013636(-) A-I      intronic chr12:57013542(-) A-I      intronic chr12:57014481(-) A-I      intronic chr12:57001927(-) A-I      intronic chr12:57001271(-) A-I      intronic chr12:57014201(-) A-I      intronic chr12:57002987(-) A-I      intronic chr12:57027681(-) A-I      intronic chr12:57002731(-) A-I      intronic chr12:57002096(-) A-I      intronic chr12:57016085(-) A-I      intronic chr12:57001336(-) A-I      intronic chr12:57016037(-) A-I      intronic chr12:57002556(-) A-I      intronic chr12:57019077(-) A-I      intronic chr12:57001788(-) A-I      intronic chr12:57001913(-) A-I      intronic chr12:57002154(-) A-I      intronic chr12:57016041(-) A-I      intronic chr12:57001819(-) A-I      intronic chr12:57002688(-) A-I      intronic chr12:57018562(-) A-I      intronic chr12:57015611(-) A-I      intronic chr12:57014404(-) A-I      intronic chr12:57001339(-) A-I      intronic chr12:57001232(-) A-I      intronic chr12:57016000(-) A-I      intronic chr12:57002375(-) A-I      intronic chr12:57002761(-) A-I      intronic chr12:57027677(-) A-I      intronic chr12:57001323(-) A-I      intronic chr12:57001436(-) A-I      intronic chr12:57019009(-) A-I      intronic chr12:57016012(-) A-I      intronic chr12:57021129(-) A-I      intronic chr12:57013671(-) A-I      intronic chr12:57001608(-) A-I      intronic chr12:57002148(-) A-I      intronic chr12:57001332(-) A-I      intronic chr12:57001376(-) A-I      intronic chr12:57012777(-) A-I      intronic chr12:57014440(-) A-I      intronic chr12:57001360(-) A-I      intronic chr12:57001620(-) A-I      intronic chr12:57003089(-) A-I      intronic chr12:57002634(-) A-I      intronic chr12:57009855(-) A-I      intronic chr12:57001413(-) A-I      intronic chr12:57016038(-) A-I      intronic chr12:57002044(-) A-I      intronic chr12:57003102(-) A-I      intronic chr12:57013600(-) A-I      intronic chr12:57013176(-) A-I      intronic chr12:57015593(-) A-I      intronic chr12:57000852(-) A-I      intronic chr12:57001428(-) A-I      intronic chr12:57003004(-) A-I      intronic chr12:57002890(-) A-I      intronic chr12:57002069(-) A-I      intronic chr12:57002529(-) A-I      intronic chr12:57002093(-) A-I      intronic chr12:57016002(-) A-I      intronic chr12:57002491(-) A-I      intronic chr12:57002112(-) A-I      intronic chr12:57001294(-) A-I      intronic chr12:57002860(-) A-I      intronic chr12:57001781(-) A-I      intronic chr12:57002859(-) A-I      intronic chr12:57009816(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BAZ2A	chr12:57001375(-) A-I intron -    21960545 chr12:57001376(-) A-I intron -    21960545 chr12:57018584(-) A-I intron -    21960545 chr12:57001376(-) A-G intron -    22484847 chr12:57001620(-) A-G intron -    22484847 chr12:57002034(-) A-G intron -    22484847 chr12:57002044(-) A-G intron -    22484847 chr12:57002786(-) A-G intron -    22484847 chr12:57002796(-) A-G intron -    22484847 chr12:57002860(-) A-G intron -    22484847 chr12:57002890(-) A-G intron -    22484847 chr12:57003051(-) A-G intron -    22484847 chr12:57001271(-) A-G intron -    22484847 chr12:57001294(-) A-G intron -    22484847 chr12:57001320(-) A-G intron -    22484847 chr12:57001323(-) A-G intron -    22484847 chr12:57001330(-) A-G intron -    22484847 chr12:57001391(-) T-C intron -    22484847 chr12:57001413(-) A-G intron -    22484847 chr12:57001436(-) A-G intron -    22484847 chr12:57001752(-) A-G intron -    22484847 chr12:57001764(-) A-G intron -    22484847 chr12:57001781(-) A-G intron -    22484847 chr12:57001788(-) A-G intron -    22484847 chr12:57001819(-) A-G intron -    22484847 chr12:57001832(-) A-G intron -    22484847 chr12:57001967(-) A-G intron -    22484847 chr12:57002096(-) A-G intron -    22484847 chr12:57002127(-) A-C intron -    22484847 chr12:57002142(-) A-G intron -    22484847 chr12:57002150(-) A-G intron -    22484847 chr12:57002154(-) A-G intron -    22484847 chr12:57002731(-) A-G intron -    22484847 chr12:57002761(-) A-G intron -    22484847 chr12:57002822(-) A-G intron -    22484847 chr12:57002859(-) A-G intron -    22484847 chr12:57002987(-) A-G intron -    22484847 chr12:57003102(-) A-G intron -    22484847 chr12:57003103(-) A-G intron -    22484847 chr12:57013542(-) A-G intron -    22484847 chr12:57013600(-) A-G intron -    22484847 chr12:57013621(-) A-G intron -    22484847 chr12:57014199(-) A-G intron -    22484847 chr12:57014201(-) A-G intron -    22484847 chr12:57014202(-) A-G intron -    22484847 chr12:57014241(-) A-G intron -    22484847 chr12:57014404(-) A-G intron -    22484847 chr12:57014441(-) A-G intron -    22484847 chr12:57015593(-) A-G intron -    22484847 chr12:57015611(-) A-G intron -    22484847 chr12:57015673(-) A-G intron -    22484847 chr12:57016000(-) A-G intron -    22484847 chr12:57016002(-) A-G intron -    22484847 chr12:57016012(-) A-G intron -    22484847 chr12:57016037(-) A-G intron -    22484847 chr12:57016038(-) A-G intron -    22484847 chr12:57016041(-) A-G intron -    22484847 chr12:57016085(-) A-G intron -    22484847 chr12:57016093(-) A-G intron -    22484847 chr12:57016831(-) A-G intron -    22484847 chr12:57016944(-) G-A intron -    22484847 chr12:57021625(-) C-T intron -    22484847 chr12:57027677(-) A-G intron -    22484847 chr12:57027681(-) A-G intron -    22484847 chr12:57027687(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BAZ2A	chr12:56989999-56990000(-) m6A 3'UTR       - chr12:56990055-56990056(-) m6A 3'UTR       27773535 chr12:56990216-56990217(-) m1A 3'UTR       26863410 chr12:56990262-56990263(-) m6A 3'UTR       24284625 chr12:56991005-56991006(-) m6A 3'UTR       - chr12:56991026-56991027(-) m6A 3'UTR       - chr12:56991086-56991087(-) m6A 3'UTR       - chr12:56991141-56991142(-) m6A 3'UTR       - chr12:56991795-56991796(-) m6A 3'UTR       24284625//27773535 chr12:56991898-56991899(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56991912-56991913(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56991939-56991940(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56991965-56991966(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56991985-56991986(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56991993-56991994(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56992173-56992174(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56992306-56992307(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56992345-56992346(-) m6A 3'UTR       24284625//24981863//27773535 chr12:56992351-56992352(-) m6A 3'UTR       24981863//27773535 chr12:56992416-56992417(-) m6A CDS       27773535 chr12:56992981-56992982(-) m1A CDS       26863410 chr12:56993065-56993066(-) m6A CDS       - chr12:56994131-56994132(-) m6A CDS       22575960 chr12:56994147-56994148(-) m6A CDS       22575960 chr12:56994166-56994167(-) m6A CDS       22575960 chr12:56995036-56995037(-) m6A CDS//exon       27773535 chr12:56995057-56995058(-) m6A CDS//exon       27773535 chr12:56995094-56995095(-) m6A CDS//exon       27773535 chr12:56995177-56995178(-) m6A CDS//exon       27773535 chr12:56995221-56995222(-) m6A exon//intron       27773535 chr12:56995229-56995230(-) m6A exon//intron       27773535 chr12:56995237-56995238(-) m6A exon//intron       24981863//27773535 chr12:56995372-56995373(-) m6A CDS       24284625//24981863//28052920//27773535 chr12:56995513-56995514(-) m6A CDS       24284625//24981863//28052920//27773535 chr12:56995518-56995519(-) m6A CDS       24284625//24981863//27773535 chr12:56995580-56995581(-) m6A CDS       24284625//24981863//27773535 chr12:56995761-56995762(-) m6A CDS       24284625 chr12:56995823-56995824(-) m6A CDS       24284625 chr12:56997151-56997152(-) m6A CDS       27773536 chr12:56997380-56997381(-) m6A CDS       24981863//27773535//27371828//27773536//22575960 chr12:56997440-56997441(-) Gm CDS       - chr12:56997458-56997459(-) m6A CDS       24981863//27773535//22575960 chr12:56997476-56997477(-) m6A CDS       24981863//27773535//22575960 chr12:56998030-56998031(-) m6A CDS//exon       22575960 chr12:56998824-56998825(-) m6A exon//intron       27773535 chr12:56999052-56999053(-) m6A CDS//exon       27371828 chr12:56999137-56999138(-) m6A exon//intron       27371828 chr12:56999173-56999174(-) m6A exon//intron       27371828 chr12:56999184-56999185(-) m6A exon//intron       27371828 chr12:56999232-56999233(-) m6A exon//intron       27371828 chr12:56999528-56999529(-) m6A exon//intron       27773535 chr12:56999546-56999547(-) m6A exon//intron       27773535 chr12:56999571-56999572(-) m6A exon//intron       27773535 chr12:56999648-56999649(-) m1A CDS//exon       26863196 chr12:56999714-56999715(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr12:56999811-56999812(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:56999825-56999826(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:57000071-57000072(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:57000078-57000079(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr12:57000433-57000434(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085 chr12:57000469-57000470(-) m1A CDS//exon       26863196 chr12:57000514-57000515(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828//22608085 chr12:57003532-57003533(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828 chr12:57003551-57003552(-) m6A CDS//exon       24981863 chr12:57003555-57003556(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828 chr12:57003560-57003561(-) m6A CDS//exon       24209618//24981863//28052920//27773535//27371828 chr12:57003630-57003631(-) m6A CDS       24209618//24981863//27773535//27371828 chr12:57003647-57003648(-) m6A CDS       24981863//27773535 chr12:57003907-57003908(-) m6A 3'UTR//CDS       27773535 chr12:57004248-57004249(-) m6A CDS       24981863//27773535 chr12:57005084-57005085(-) m6A exon//intron       24981863//27773535//27371828 chr12:57005657-57005658(-) Y CDS       26075521 chr12:57005963-57005964(-) m6A CDS       24981863//27773535 chr12:57005976-57005977(-) m6A CDS       27773535 chr12:57005992-57005993(-) m6A CDS       27773535 chr12:57006861-57006862(-) m6A CDS//exon       27773535 chr12:57006941-57006942(-) m6A CDS//exon       27773535 chr12:57006959-57006960(-) m6A CDS//exon       27773535 chr12:57007000-57007001(-) m6A CDS//exon       27773535 chr12:57008929-57008930(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:57008959-57008960(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:57008987-57008988(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:57009035-57009036(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:57009176-57009177(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr12:57009207-57009208(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr12:57009252-57009253(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr12:57009321-57009322(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:57011198-57011199(-) m6A CDS//exon//intron       24284625//24209618//27773535 chr12:57011248-57011249(-) m6A CDS//exon//intron       24284625//24209618//27773535 chr12:57011254-57011255(-) m6A CDS//exon//intron       24284625//24209618//27773535 chr12:57023836-57023837(-) m6A 5'UTR//intron       27773535 chr12:57023965-57023966(-) m6A 5'UTR//exon//intron       24284625//27371828 chr12:57024022-57024023(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828 chr12:57024029-57024030(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828 chr12:57024036-57024037(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828 chr12:57024564-57024565(-) m6A 5'UTR//exon//intron       24981863//27371828 chr12:57024583-57024584(-) m6A 5'UTR//exon//intron       24981863//27371828 chr12:57030015-57030016(-) m6A 5'UTR//exon       24981863//27773535 chr12:57030146-57030147(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BAZ2A	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: BAZ2A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.