Basic Information:

  VIRBase ID:  

VHID00426551

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          DLG5:  NM_004747     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	DLG5
miRBase Accession/Entrez ID	MIMAT0002180	9231
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	LP-DLG//P-DLG5//PDLG

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DLG5	chr10:79575306(-) A-I      intronic chr10:79575342(-) A-I      intronic chr10:79566150(-) A-I      intronic chr10:79575372(-) A-I      intronic chr10:79575383(-) A-I      intronic chr10:79607567(-) A-I      intronic chr10:79607716(-) A-I      intronic chr10:79607646(-) A-I      intronic chr10:79607664(-) A-I      intronic chr10:79607683(-) A-I      intronic chr10:79607692(-) A-I      intronic chr10:79655154(-) A-I      intronic chr10:79607720(-) A-I      intronic chr10:79607759(-) A-I      intronic chr10:79670692(-) A-I      intronic chr10:79655177(-) A-I      intronic chr10:79655180(-) A-I      intronic chr10:79586265(-) A-I      intronic chr10:79671137(-) A-I      intronic chr10:79671152(-) A-I      intronic chr10:79655155(-) A-I      intronic chr10:79568248(-) A-I      intronic chr10:79573873(-) A-I      intronic chr10:79575252(-) A-I      intronic chr10:79575296(-) A-I      intronic chr10:79655119(-) A-I      intronic chr10:79666651(-) A-I      intronic chr10:79631573(-) A-I      intronic chr10:79643545(-) A-I      intronic chr10:79643522(-) A-I      intronic chr10:79631368(-) A-I      intronic chr10:79631501(-) A-I      intronic chr10:79568998(-) A-I      intronic chr10:79643517(-) A-I      intronic chr10:79636052(-) A-I      intronic chr10:79666602(-) A-I      intronic chr10:79568256(-) A-I      intronic chr10:79586584(-) A-I      intronic chr10:79631343(-) A-I      intronic chr10:79588188(-) A-I      intronic chr10:79568906(-) A-I      intronic chr10:79587177(-) A-I      intronic chr10:79568650(-) A-I      intronic chr10:79574009(-) A-I      intronic chr10:79670473(-) A-I      intronic chr10:79557882(-) A-I      intronic chr10:79583555(-) A-I      intronic chr10:79587112(-) A-I      intronic chr10:79606369(-) A-I      intronic chr10:79557947(-) A-I      intronic chr10:79587051(-) A-I      intronic chr10:79586201(-) A-I      intronic chr10:79586623(-) A-I      intronic chr10:79563817(-) A-I      intronic chr10:79586373(-) A-I      intronic chr10:79587036(-) A-I      intronic chr10:79586616(-) A-I      intronic chr10:79568735(-) A-I      intronic chr10:79670699(-) A-I      intronic chr10:79666494(-) A-I      intronic chr10:79568117(-) A-I      intronic chr10:79663134(-) A-I      intronic chr10:79582159(-) A-I      intronic chr10:79666583(-) A-I      intronic chr10:79586568(-) A-I      intronic chr10:79586562(-) A-I      intronic chr10:79564888(-) A-I      intronic chr10:79611909(-) A-I      intronic chr10:79557740(-) A-I      intronic chr10:79569120(-) A-I      intronic chr10:79683514(-) A-I      intronic chr10:79574599(-) A-I      intronic chr10:79574593(-) A-I      intronic chr10:79557741(-) A-I      intronic chr10:79574579(-) A-I      intronic chr10:79612441(-) A-I      intronic chr10:79573904(-) A-I      intronic chr10:79586557(-) A-I      intronic chr10:79575196(-) A-I      intronic chr10:79568110(-) A-I      intronic chr10:79573743(-) A-I      intronic chr10:79568127(-) A-I      intronic chr10:79612415(-) A-I      intronic chr10:79573741(-) A-I      intronic chr10:79557760(-) A-I      intronic chr10:79586379(-) A-I      intronic chr10:79671168(-) A-I      intronic chr10:79586489(-) A-I      intronic chr10:79557774(-) A-I      intronic chr10:79620304(-) A-I      intronic chr10:79583461(-) A-I      intronic chr10:79583456(-) A-I      intronic chr10:79607593(-) A-I      intronic chr10:79587166(-) A-I      intronic chr10:79587161(-) A-I      intronic chr10:79588061(-) A-I      intronic chr10:79675896(-) A-I      intronic chr10:79586259(-) A-I      intronic chr10:79573900(-) A-I      intronic chr10:79666496(-) A-I      intronic chr10:79568636(-) A-I      intronic chr10:79588078(-) A-I      intronic chr10:79611901(-) A-I      intronic chr10:79683502(-) A-I      intronic chr10:79586275(-) A-I      intronic chr10:79683472(-) A-I      intronic chr10:79683469(-) A-I      intronic chr10:79683388(-) A-I      intronic chr10:79683351(-) A-I      intronic chr10:79677005(-) A-I      intronic chr10:79676245(-) A-I      intronic chr10:79675003(-) A-I      intronic chr10:79587148(-) A-I      intronic chr10:79675002(-) A-I      intronic chr10:79670983(-) A-I      intronic chr10:79587121(-) A-I      intronic chr10:79670621(-) A-I      intronic chr10:79670572(-) A-I      intronic chr10:79667285(-) A-I      intronic chr10:79683272(-) A-I      intronic chr10:79667120(-) A-I      intronic chr10:79667092(-) A-I      intronic chr10:79595574(-) A-I      NonSyn:Glu->Gly chr10:79585442(-) A-I      intronic chr10:79664958(-) A-I      intronic chr10:79666451(-) A-I      intronic chr10:79586670(-) A-I      intronic chr10:79568281(-) A-I      intronic chr10:79676230(-) A-I      intronic chr10:79675856(-) A-I      intronic chr10:79636040(-) A-I      intronic chr10:79618683(-) A-I      intronic chr10:79559505(-) A-I      intronic chr10:79667093(-) A-I      intronic chr10:79568103(-) A-I      intronic chr10:79640046(-) A-I      intronic chr10:79586649(-) A-I      intronic chr10:79618833(-) A-I      intronic chr10:79678148(-) A-I      intronic chr10:79612862(-) A-I      intronic chr10:79670647(-) A-I      intronic chr10:79574022(-) A-I      intronic chr10:79586219(-) A-I      intronic chr10:79574405(-) A-I      intronic chr10:79671712(-) A-I      intronic chr10:79671146(-) A-I      intronic chr10:79676282(-) A-I      intronic chr10:79676187(-) A-I      intronic chr10:79586620(-) A-I      intronic chr10:79640803(-) A-I      intronic chr10:79675895(-) A-I      intronic chr10:79586130(-) A-I      intronic chr10:79683656(-) A-I      intronic chr10:79667085(-) A-I      intronic chr10:79569064(-) A-I      intronic chr10:79618360(-) A-I      intronic chr10:79585514(-) A-I      intronic chr10:79683711(-) A-I      intronic chr10:79674830(-) A-I      intronic chr10:79606368(-) A-I      intronic chr10:79640949(-) A-I      intronic chr10:79612879(-) A-I      intronic chr10:79586705(-) A-I      intronic chr10:79650331(-) A-I      intronic chr10:79588081(-) A-I      intronic chr10:79667207(-) A-I      intronic chr10:79676186(-) A-I      intronic chr10:79579882(-) A-I      intronic chr10:79588145(-) A-I      intronic chr10:79574565(-) A-I      intronic chr10:79574551(-) A-I      intronic chr10:79568254(-) A-I      intronic chr10:79618755(-) A-I      intronic chr10:79586619(-) A-I      intronic chr10:79568302(-) A-I      intronic chr10:79585513(-) A-I      intronic chr10:79666531(-) A-I      intronic chr10:79675790(-) A-I      intronic chr10:79618362(-) A-I      intronic chr10:79586239(-) A-I      intronic chr10:79683407(-) A-I      intronic chr10:79676252(-) A-I      intronic chr10:79671791(-) A-I      intronic chr10:79612873(-) A-I      intronic chr10:79612029(-) A-I      intronic chr10:79665052(-) A-I      intronic chr10:79671159(-) A-I      intronic chr10:79674985(-) A-I      intronic chr10:79607554(-) A-I      intronic chr10:79650318(-) A-I      intronic chr10:79670581(-) A-I      intronic chr10:79670546(-) A-I      intronic chr10:79585494(-) A-I      intronic chr10:79670526(-) A-I      intronic chr10:79667311(-) A-I      intronic chr10:79562495(-) A-I      intronic chr10:79666663(-) A-I      intronic chr10:79666450(-) A-I      intronic chr10:79573772(-) A-I      intronic chr10:79673606(-) A-I      intronic chr10:79568229(-) A-I      intronic chr10:79683665(-) A-I      intronic chr10:79586222(-) A-I      intronic chr10:79585485(-) A-I      intronic chr10:79568289(-) A-I      intronic chr10:79568249(-) A-I      intronic chr10:79569101(-) A-I      intronic chr10:79672279(-) A-I      intronic chr10:79655756(-) A-I      intronic chr10:79664986(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DLG5	chr10:79595574(-) A-I exon CDS    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DLG5	chr10:79550586-79550587(-) m6A 3'UTR//exon       27773535 chr10:79550631-79550632(-) m6A 3'UTR//exon       27773535 chr10:79550650-79550651(-) m6A 3'UTR//exon       27773535 chr10:79550674-79550675(-) m6A 3'UTR//exon       27773535 chr10:79550720-79550721(-) m6A 3'UTR//exon       27773535 chr10:79550746-79550747(-) m6A 3'UTR//exon       27773535 chr10:79550753-79550754(-) m6A 3'UTR//exon       27773535 chr10:79551467-79551468(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr10:79551512-79551513(-) Y 3'UTR//exon       26075521 chr10:79551541-79551542(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79551600-79551601(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79551618-79551619(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79551676-79551677(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:79551692-79551693(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:79551737-79551738(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:79551897-79551898(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr10:79551968-79551969(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79552046-79552047(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79552069-79552070(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79552075-79552076(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79552097-79552098(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79552145-79552146(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79552152-79552153(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79552236-79552237(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr10:79553306-79553307(-) m6A exon//intron       24284625//24209618 chr10:79553313-79553314(-) m6A exon//intron       24284625//24209618 chr10:79553335-79553336(-) m6A exon//intron       24284625 chr10:79553845-79553846(-) m6A CDS//exon       24284625//27773535//22575960 chr10:79553863-79553864(-) m6A CDS//exon       24284625//27773535//22575960 chr10:79554696-79554697(-) m6A CDS//exon       24284625//27773535 chr10:79565613-79565614(-) m6A 3'UTR//CDS//exon       27773535 chr10:79567674-79567675(-) m6A 3'UTR//CDS//exon       24284625 chr10:79567679-79567680(-) m6A 3'UTR//CDS//exon       24284625 chr10:79569317-79569318(-) m6A 3'UTR//CDS//exon       24284625 chr10:79569392-79569393(-) m6A 3'UTR//CDS//exon       24284625 chr10:79569462-79569463(-) m6A 3'UTR//CDS//exon       24284625 chr10:79570980-79570981(-) m6A 3'UTR//CDS//exon       24284625 chr10:79571801-79571802(-) m6A 3'UTR//CDS//exon       24284625 chr10:79576375-79576376(-) m6A 3'UTR//CDS//exon       27773535 chr10:79576410-79576411(-) m6A 3'UTR//CDS//exon       27773535 chr10:79577603-79577604(-) m6A 3'UTR//CDS//exon       24284625 chr10:79577617-79577618(-) m6A 3'UTR//CDS//exon       24284625 chr10:79579168-79579169(-) m6A 3'UTR//CDS//exon       24284625 chr10:79579746-79579747(-) m6A 3'UTR//CDS//exon       24284625 chr10:79579773-79579774(-) m6A 3'UTR//CDS//exon       24284625 chr10:79579799-79579800(-) m6A exon//intron       24284625 chr10:79580951-79580952(-) m6A 3'UTR//CDS//exon//intron       24284625 chr10:79580990-79580991(-) m6A 3'UTR//CDS//exon//intron       24284625 chr10:79581074-79581075(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535 chr10:79581153-79581154(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828 chr10:79581199-79581200(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//27371828 chr10:79581275-79581276(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79581291-79581292(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr10:79581405-79581406(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr10:79581431-79581432(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr10:79581440-79581441(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr10:79581480-79581481(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr10:79581536-79581537(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr10:79581616-79581617(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr10:79581680-79581681(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79581683-79581684(-) Am 3'UTR//CDS//exon//intron       - chr10:79581692-79581693(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79581711-79581712(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79581740-79581741(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79581803-79581804(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr10:79581824-79581825(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:79584166-79584167(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr10:79584214-79584215(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535 chr10:79584466-79584467(-) m6A exon//intron       24284625 chr10:79588652-79588653(-) m6A 3'UTR//CDS//exon       24284625//24209618 chr10:79589119-79589120(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535//27773536 chr10:79589237-79589238(-) m6A 3'UTR//CDS//exon       24209618//27773535//27371828//27773536 chr10:79589252-79589253(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535 chr10:79590004-79590005(-) m6A 3'UTR//CDS//exon       24284625//24209618//27773535//22575960 chr10:79590031-79590032(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960 chr10:79590627-79590628(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960 chr10:79593764-79593765(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//22575960 chr10:79595525-79595526(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//22575960 chr10:79595546-79595547(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//22575960 chr10:79595632-79595633(-) Y 3'UTR//CDS//intron       26075521 chr10:79595672-79595673(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601640-79601641(-) Cm 3'UTR//CDS//intron       - chr10:79601724-79601725(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601735-79601736(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601835-79601836(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601850-79601851(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601900-79601901(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601906-79601907(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79601924-79601925(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr10:79603249-79603250(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27371828//27773536 chr10:79603274-79603275(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27371828//27773536 chr10:79603294-79603295(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27371828//27773536 chr10:79603327-79603328(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27773536 chr10:79603381-79603382(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//27773536 chr10:79603405-79603406(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//27773536 chr10:79603425-79603426(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773535//27371828//27773536 chr10:79605013-79605014(-) m6A 3'UTR//intron       24284625//24209618 chr10:79613143-79613144(-) Gm CDS//intron       - chr10:79613151-79613152(-) m6A CDS//intron       24284625//24209618//27773536 chr10:79613175-79613176(-) m6A CDS//intron       24284625//24209618//27773535//27773536//22575960 chr10:79613199-79613200(-) m6A CDS//intron       24284625//24209618//27773535//27773536//22575960 chr10:79613241-79613242(-) m6A CDS//intron       24284625//24209618//27773535//27773536//22575960 chr10:79613263-79613264(-) m6A CDS//intron       24284625//27773535//27773536//22575960 chr10:79613997-79613998(-) m6A CDS//intron       24284625//27773536//22575960 chr10:79614044-79614045(-) m6A CDS//intron       24284625//22575960 chr10:79614062-79614063(-) m6A CDS//intron       24284625 chr10:79616580-79616581(-) m6A CDS//intron       24284625//24981863//27773536 chr10:79628862-79628863(-) m6A exon//intron       24284625//27773536 chr10:79628918-79628919(-) m6A CDS//exon       24284625//27773536 chr10:79649207-79649208(-) m6A CDS//intron       24284625 chr10:79649235-79649236(-) m6A CDS//intron       24284625 chr10:79649248-79649249(-) m6A CDS//intron       24284625 chr10:79686069-79686070(-) m6A CDS       27773536 chr10:79686081-79686082(-) m6A CDS       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DLG5	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: DLG5

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//RNAHybrid
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.