Detail Information

Basic Information:


  VIRBase ID:  

VHID00425584

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:           ZNF776:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10a-3p ZNF776
miRBase
Accession/Entrez ID		 MIMAT0002179 284309
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF776
chr19:58261568(+) A-I      intronic
chr19:58261591(+) A-I      intronic
chr19:58261616(+) A-I      intronic
chr19:58261712(+) A-I      intronic
chr19:58261614(+) A-I      intronic
chr19:58261608(+) A-I      intronic
chr19:58260532(+) A-I      intronic
chr19:58261779(+) A-I      intronic
chr19:58261813(+) A-I      intronic
chr19:58268230(+) A-I      3'UTR
chr19:58268238(+) A-I      3'UTR
chr19:58268439(+) A-I      3'UTR
chr19:58261702(+) A-I      intronic
chr19:58261597(+) A-I      intronic
chr19:58260414(+) A-I      intronic
chr19:58261790(+) A-I      intronic
chr19:58261701(+) A-I      intronic
chr19:58261728(+) A-I      intronic
chr19:58260360(+) A-I      intronic
chr19:58260454(+) A-I      intronic
chr19:58261615(+) A-I      intronic
chr19:58268385(+) A-I      3'UTR
chr19:58261755(+) A-I      intronic
chr19:58260401(+) A-I      intronic
chr19:58268478(+) A-I      3'UTR
chr19:58260542(+) A-I      intronic
chr19:58268415(+) A-I      3'UTR
chr19:58260520(+) A-I      intronic
chr19:58268387(+) A-I      3'UTR
chr19:58268443(+) A-I      3'UTR
chr19:58268389(+) A-I      3'UTR
chr19:58260606(+) A-I      intronic
chr19:58260430(+) A-I      intronic
chr19:58261585(+) A-I      intronic
chr19:58260348(+) A-I      intronic
chr19:58261582(+) A-I      intronic
chr19:58261732(+) A-I      intronic
chr19:58261610(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZNF776
chr19:58268385(+) A-I intron -    21960545   //22327324
chr19:58268387(+) A-I intron -    21960545   //22327324
chr19:58268472(+) A-I intron -    21960545   //22327324
chr19:58261582(+) A-I intron -    21960545
chr19:58264558(+) A-I intron -    21960545
chr19:58260542(+) A-G intron -    22484847
chr19:58261615(+) A-G intron -    22484847
chr19:58261732(+) A-G intron -    22484847
chr19:58268385(+) A-G intron -    22484847
chr19:58268387(+) A-G intron -    22484847
chr19:58268472(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF776
chr19:58258225-58258226(+) m6A 5'UTR//exon       24981863
chr19:58258259-58258260(+) m6A 5'UTR//exon       24981863
chr19:58264684-58264685(+) m6A 3'UTR//CDS//intron       24981863//22608085
chr19:58264699-58264700(+) m6A 3'UTR//CDS//intron       24981863//22608085
chr19:58264732-58264733(+) m6A 3'UTR//CDS//intron       24981863//22608085
chr19:58264741-58264742(+) m6A 3'UTR//CDS//intron       24284625//24981863//22608085
chr19:58264816-58264817(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58264880-58264881(+) m6A CDS//intron       24284625//24209618//24981863//22608085
chr19:58264892-58264893(+) m6A CDS//intron       24284625//24209618//24981863//22608085
chr19:58264942-58264943(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58264958-58264959(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58265012-58265013(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265048-58265049(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265072-58265073(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265080-58265081(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265113-58265114(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265157-58265158(+) m6A CDS//intron       24284625//24981863//22575960//22608085
chr19:58265181-58265182(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58265199-58265200(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58265283-58265284(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58265298-58265299(+) m6A CDS//intron       24284625//24981863//22608085
chr19:58265340-58265341(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265367-58265368(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085
chr19:58265451-58265452(+) m6A CDS//exon//intron       24284625//24209618//24981863//22608085
chr19:58265535-58265536(+) m6A CDS//exon//intron       24284625//24981863//22608085
chr19:58265619-58265620(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085
chr19:58265676-58265677(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085
chr19:58265703-58265704(+) m6A CDS//exon//intron       24284625//25456834//24981863//27773535//22608085
chr19:58265760-58265761(+) m6A CDS//exon//intron       24284625//24981863//27773535//22608085
chr19:58266289-58266290(+) m6A 3'UTR//exon//intron       24981863//22608085
chr19:58266346-58266347(+) m6A 3'UTR//exon//intron       24981863//22608085
chr19:58266542-58266543(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22608085
chr19:58266587-58266588(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22608085
chr19:58266603-58266604(+) m6A 3'UTR//exon//intron       24284625//25456834//24981863//22608085
chr19:58266658-58266659(+) m6A 3'UTR//exon//intron       25456834//24981863//22608085
chr19:58266742-58266743(+) m6A 3'UTR//exon//intron       22608085
chr19:58266845-58266846(+) m6A 3'UTR//exon//intron       24981863//22608085
chr19:58267006-58267007(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085
chr19:58267302-58267303(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:58267423-58267424(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr19:58267447-58267448(+) m6A 3'UTR//intron       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZNF776
Chromatin K562 cells     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10a-3p
Interactor2: ZNF776

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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