Basic Information:

  VIRBase ID:  

VHID00425379

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:  MIMAT0002179          CMTM4:  NM_178818     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-3p	CMTM4
miRBase Accession/Entrez ID	MIMAT0002179	146223
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CKLFSF4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CMTM4	chr16:66725386(-) A-I      intronic chr16:66725383(-) A-I      intronic chr16:66725400(-) A-I      intronic chr16:66725522(-) A-I      intronic chr16:66725360(-) A-I      intronic chr16:66689977(-) A-I      intronic chr16:66679800(-) A-I      intronic chr16:66666803(-) A-I      intronic chr16:66725359(-) A-I      intronic chr16:66715058(-) A-I      intronic chr16:66725401(-) A-I      intronic chr16:66700984(-) A-I      intronic chr16:66715048(-) A-I      intronic chr16:66715045(-) A-I      intronic chr16:66725387(-) A-I      intronic chr16:66725412(-) A-I      intronic chr16:66725399(-) A-I      intronic chr16:66715042(-) A-I      intronic chr16:66726882(-) A-I      intronic chr16:66717440(-) A-I      intronic chr16:66717468(-) A-I      intronic chr16:66697522(-) A-I      intronic chr16:66717359(-) A-I      intronic chr16:66719727(-) A-I      intronic chr16:66721399(-) A-I      intronic chr16:66676885(-) A-I      intronic chr16:66717333(-) A-I      intronic chr16:66714433(-) A-I      intronic chr16:66711751(-) A-I      intronic chr16:66711726(-) A-I      intronic chr16:66709901(-) A-I      intronic chr16:66709095(-) A-I      intronic chr16:66709089(-) A-I      intronic chr16:66709080(-) A-I      intronic chr16:66709076(-) A-I      intronic chr16:66709069(-) A-I      intronic chr16:66707315(-) A-I      intronic chr16:66707278(-) A-I      intronic chr16:66707267(-) A-I      intronic chr16:66666751(-) A-I      intronic chr16:66707187(-) A-I      intronic chr16:66697901(-) A-I      intronic chr16:66697708(-) A-I      intronic chr16:66697641(-) A-I      intronic chr16:66697625(-) A-I      intronic chr16:66726883(-) A-I      intronic chr16:66676893(-) A-I      intronic chr16:66725020(-) A-I      intronic chr16:66724968(-) A-I      intronic chr16:66726924(-) A-I      intronic chr16:66691128(-) A-I      intronic chr16:66724788(-) A-I      intronic chr16:66726090(-) A-I      intronic chr16:66726153(-) A-I      intronic chr16:66687733(-) A-I      intronic chr16:66702003(-) A-I      intronic chr16:66707249(-) A-I      intronic chr16:66707093(-) A-I      intronic chr16:66699892(-) A-I      intronic chr16:66706651(-) A-I      intronic chr16:66689833(-) A-I      intronic chr16:66726023(-) A-I      intronic chr16:66714119(-) A-I      intronic chr16:66692038(-) A-I      intronic chr16:66706934(-) A-I      intronic chr16:66724813(-) A-I      intronic chr16:66714335(-) A-I      intronic chr16:66717363(-) A-I      intronic chr16:66726892(-) A-I      intronic chr16:66727925(-) A-I      intronic chr16:66702043(-) A-I      intronic chr16:66719652(-) A-I      intronic chr16:66726923(-) A-I      intronic chr16:66676532(-) A-I      intronic chr16:66705874(-) A-I      intronic chr16:66706950(-) A-I      intronic chr16:66695789(-) A-I      intronic chr16:66678930(-) A-I      intronic chr16:66707022(-) A-I      intronic chr16:66715075(-) A-I      intronic chr16:66720012(-) A-I      intronic chr16:66680678(-) A-I      intronic chr16:66697583(-) A-I      intronic chr16:66699083(-) A-I      intronic chr16:66699011(-) A-I      intronic chr16:66666794(-) A-I      intronic chr16:66715458(-) A-I      intronic chr16:66697873(-) A-I      intronic chr16:66666876(-) A-I      intronic chr16:66697346(-) A-I      intronic chr16:66726727(-) A-I      intronic chr16:66697322(-) A-I      intronic chr16:66675118(-) A-I      intronic chr16:66698955(-) A-I      intronic chr16:66706945(-) A-I      intronic chr16:66698814(-) A-I      intronic chr16:66723442(-) A-I      intronic chr16:66691240(-) A-I      intronic chr16:66679333(-) A-I      intronic chr16:66697557(-) A-I      intronic chr16:66726157(-) A-I      intronic chr16:66714199(-) A-I      intronic chr16:66706723(-) A-I      intronic chr16:66675076(-) A-I      intronic chr16:66702029(-) A-I      intronic chr16:66703516(-) A-I      intronic chr16:66715428(-) A-I      intronic chr16:66709264(-) A-I      intronic chr16:66698985(-) A-I      intronic chr16:66677056(-) A-I      intronic chr16:66680677(-) A-I      intronic chr16:66701684(-) A-I      intronic chr16:66698949(-) A-I      intronic chr16:66714320(-) A-I      intronic chr16:66727911(-) A-I      intronic chr16:66715384(-) A-I      intronic chr16:66702033(-) A-I      intronic chr16:66706951(-) A-I      intronic chr16:66726066(-) A-I      intronic chr16:66699078(-) A-I      intronic chr16:66707239(-) A-I      intronic chr16:66687734(-) A-I      intronic chr16:66697323(-) A-I      intronic chr16:66705871(-) A-I      intronic chr16:66706724(-) A-I      intronic chr16:66701145(-) A-I      intronic chr16:66680670(-) A-I      intronic chr16:66699095(-) A-I      intronic chr16:66704508(-) A-I      intronic chr16:66707384(-) A-I      intronic chr16:66701549(-) A-I      intronic chr16:66679318(-) A-I      intronic chr16:66679324(-) A-I      intronic chr16:66706129(-) A-I      intronic chr16:66714299(-) A-I      intronic chr16:66725438(-) A-I      intronic chr16:66699055(-) A-I      intronic chr16:66698984(-) A-I      intronic chr16:66705869(-) A-I      intronic chr16:66714138(-) A-I      intronic chr16:66715479(-) A-I      intronic chr16:66710951(-) A-I      intronic chr16:66675119(-) A-I      intronic chr16:66707378(-) A-I      intronic chr16:66701772(-) A-I      intronic chr16:66697364(-) A-I      intronic chr16:66697678(-) A-I      intronic chr16:66725509(-) A-I      intronic chr16:66695784(-) A-I      intronic chr16:66710908(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CMTM4	chr16:66680670(-) A-I intron -    15545495 chr16:66680677(-) A-I intron -    15545495 chr16:66680678(-) A-I intron -    15545495

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CMTM4	chr16:66650458-66650459(-) m6A 3'UTR//exon       24981863 chr16:66650471-66650472(-) m6A 3'UTR//exon       24981863 chr16:66655647-66655648(-) m6A 3'UTR//exon//intron       24981863 chr16:66655957-66655958(-) m6A 3'UTR//intron       24284625//25456834//24981863 chr16:66655967-66655968(-) m6A CDS       24284625//25456834//24981863//27773536 chr16:66655994-66655995(-) m6A CDS       24284625//25456834//24981863//27773536 chr16:66656087-66656088(-) m6A CDS       24284625 chr16:66657337-66657338(-) m6A CDS       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CMTM4	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-3p
Interactor2: CMTM4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.