Basic Information:

  VIRBase ID:  

VHID00424090

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:  MIMAT0002179          PPIF:  NM_005729     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-3p	PPIF
miRBase Accession/Entrez ID	MIMAT0002179	10105
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Cyp-D//CyP-M//CYP3//CypD

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPIF	chr10:81109644(+) A-I      intronic chr10:81110343(+) A-I      intronic chr10:81109655(+) A-I      intronic chr10:81109710(+) A-I      intronic chr10:81109666(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPIF	chr10:81107437-81107438(+) m6A CDS//exon       24284625//27773536//22575960 chr10:81108855-81108856(+) m6A CDS//exon       24284625//22575960 chr10:81109423-81109424(+) m6A CDS//exon       24284625//22575960 chr10:81111312-81111313(+) m6A CDS//exon       24284625 chr10:81112140-81112141(+) m6A 3'UTR//CDS       24284625//22575960 chr10:81113553-81113554(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22575960 chr10:81113578-81113579(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22575960 chr10:81113746-81113747(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:81113758-81113759(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr10:81113822-81113823(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:81113891-81113892(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:81113949-81113950(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:81113969-81113970(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr10:81114039-81114040(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:81114098-81114099(+) m6A 3'UTR       24284625//24209618//26404942//22575960 chr10:81114120-81114121(+) m6A 3'UTR       24284625//22575960 chr10:81114240-81114241(+) m6A 3'UTR       24284625//22575960 chr10:81114248-81114249(+) m6A 3'UTR       24284625//22575960 chr10:81114274-81114275(+) m6A 3'UTR       24284625 chr10:81114474-81114475(+) m6A 3'UTR       24284625 chr10:81114627-81114628(+) m6A 3'UTR       24284625 chr10:81114780-81114781(+) m6A 3'UTR       24284625//24981863 chr10:81115057-81115058(+) m6A 3'UTR       24284625//24981863 chr10:81115073-81115074(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PPIF	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-3p
Interactor2: PPIF

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.