Detail Information

Basic Information:


  VIRBase ID:  

VHID00423767

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9933

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:           TGFBR2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10a-3p TGFBR2
miRBase
Accession/Entrez ID		 MIMAT0002179 7048
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - AAT3//FAA3//LDS1B//LDS2//LDS2B//MFS2//RIIC//TAAD2//TBR-ii//TBRII//TGFbeta-RII//TGFR-2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TGFBR2
chr3:30664265(+) A-I      intronic
chr3:30664284(+) A-I      intronic
chr3:30664287(+) A-I      intronic
chr3:30664293(+) A-I      intronic
chr3:30664304(+) A-I      intronic
chr3:30665746(+) A-I      intronic
chr3:30665745(+) A-I      intronic
chr3:30665726(+) A-I      intronic
chr3:30665720(+) A-I      intronic
chr3:30665709(+) A-I      intronic
chr3:30665707(+) A-I      intronic
chr3:30665703(+) A-I      intronic
chr3:30720027(+) A-I      intronic
chr3:30719947(+) A-I      intronic
chr3:30664329(+) A-I      intronic
chr3:30664313(+) A-I      intronic
chr3:30664297(+) A-I      intronic
chr3:30664269(+) A-I      intronic
chr3:30664241(+) A-I      intronic
chr3:30664229(+) A-I      intronic
chr3:30664225(+) A-I      intronic
chr3:30664124(+) A-I      intronic
chr3:30664119(+) A-I      intronic
chr3:30664118(+) A-I      intronic
chr3:30661424(+) A-I      intronic
chr3:30669104(+) A-I      intronic
chr3:30669107(+) A-I      intronic
chr3:30669135(+) A-I      intronic
chr3:30669078(+) A-I      intronic
chr3:30664110(+) A-I      intronic
chr3:30735159(+) A-I      3'UTR
chr3:30665855(+) A-I      intronic
chr3:30710514(+) A-I      intronic
chr3:30717074(+) A-I      intronic
chr3:30719919(+) A-I      intronic
chr3:30716991(+) A-I      intronic
chr3:30664103(+) A-I      intronic
chr3:30716983(+) A-I      intronic
chr3:30665854(+) A-I      intronic
chr3:30710654(+) A-I      intronic
chr3:30710520(+) A-I      intronic
chr3:30710661(+) A-I      intronic
chr3:30719893(+) A-I      intronic
chr3:30719961(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TGFBR2
chr3:30648140-30648141(+) m6A 5'UTR       24981863
chr3:30648151-30648152(+) m6A 5'UTR       24209618//24981863
chr3:30664743-30664744(+) m6A CDS//intron       26404942
chr3:30664760-30664761(+) m6A CDS//intron       26404942
chr3:30691778-30691779(+) m6A CDS       24284625//26404942
chr3:30691792-30691793(+) m6A CDS       26404942
chr3:30691891-30691892(+) m6A CDS       26404942
chr3:30713281-30713282(+) m6A CDS       26404942
chr3:30713414-30713415(+) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr3:30713471-30713472(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713491-30713492(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713539-30713540(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713549-30713550(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713561-30713562(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713582-30713583(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr3:30713631-30713632(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr3:30713711-30713712(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr3:30713810-30713811(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr3:30713888-30713889(+) m6A CDS       24284625//24981863//26404942
chr3:30715602-30715603(+) m6A CDS       24981863
chr3:30715674-30715675(+) m6A CDS       -
chr3:30729944-30729945(+) m6A CDS       -
chr3:30732951-30732952(+) m6A CDS       24284625//24981863//26404942
chr3:30733020-30733021(+) m6A CDS       24284625//24981863//26404942
chr3:30733077-30733078(+) m6A CDS       24284625//24981863//26404942
chr3:30733145-30733146(+) m6A 3'UTR       25456834//24981863//26404942//22608085
chr3:30733172-30733173(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085
chr3:30733190-30733191(+) m6A 3'UTR       24284625//25456834//24981863//26404942
chr3:30733237-30733238(+) m6A 3'UTR       24284625//25456834//24981863//26404942
chr3:30733467-30733468(+) m6A 3'UTR       26404942
chr3:30733477-30733478(+) m6A 3'UTR       26404942
chr3:30733514-30733515(+) m6A 3'UTR       26404942
chr3:30733522-30733523(+) m6A 3'UTR       26404942
chr3:30733528-30733529(+) Cm 3'UTR       -
chr3:30733542-30733543(+) m6A 3'UTR       26404942
chr3:30733599-30733600(+) m6A 3'UTR       26404942
chr3:30733606-30733607(+) m6A 3'UTR       26404942
chr3:30733783-30733784(+) m6A 3'UTR       -
chr3:30733831-30733832(+) m6A 3'UTR       27773535
chr3:30733855-30733856(+) m6A 3'UTR       27773535
chr3:30733890-30733891(+) m6A 3'UTR       27773535
chr3:30733929-30733930(+) m6A 3'UTR       27773535
chr3:30734129-30734130(+) m6A 3'UTR       26404942
chr3:30734225-30734226(+) m6A 3'UTR       26404942
chr3:30734247-30734248(+) m6A 3'UTR       26404942
chr3:30734402-30734403(+) m6A 3'UTR       26404942
chr3:30734435-30734436(+) m6A 3'UTR       26404942
chr3:30734463-30734464(+) m6A 3'UTR       26404942
chr3:30735441-30735442(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TGFBR2
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10a-3p
Interactor2: TGFBR2

Evidence Support:


Strong-Evidence IFA//Luciferase reporter assay//qRT-PCR//RT-PCR//Western blot
Support Database ViRBase//VIRmiRNA

References:


PMID 22915806 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line 293 cells//TIME cells Interactor2 expression Downregulation
Description KSHV miR-K10 variants inhibit TGF-beta signaling by targeting TGF-beta type II receptor (TbetaRII). A suppressor of the miRs sensitizes latent KSHV-infected PEL cells to TGF-beta and induces apoptosis. These results indicate that miR-K10 variants manipulate the TGF-beta pathway to confer cells with resistance to the growth-inhibitory effect of TGF-beta. Thus, KSHV miRs might target the tumor-suppressive TGF-beta pathway to promote viral latency and contribute to malignant cellular transformation.

Starting a new search, please wait ...