Detail Information

Basic Information:


  VIRBase ID:  

VHID00423700

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:           SLA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10a-3p SLA
miRBase
Accession/Entrez ID		 MIMAT0002179 6503
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - SLA1//SLAP

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SLA
chr8:134049140-134049141(-) m6A 3'UTR       26404942
chr8:134049177-134049178(-) m6A 3'UTR       26404942
chr8:134049214-134049215(-) m6A 3'UTR       26404942
chr8:134049259-134049260(-) m6A 3'UTR       26404942
chr8:134049396-134049397(-) m6A 3'UTR       26404942
chr8:134049518-134049519(-) m6A 3'UTR       26404942
chr8:134049530-134049531(-) m6A 3'UTR       26404942
chr8:134049759-134049760(-) m6A 3'UTR       26404942
chr8:134049770-134049771(-) m6A 3'UTR       26404942
chr8:134049820-134049821(-) m6A 3'UTR       26404942
chr8:134049839-134049840(-) m6A 3'UTR       26404942
chr8:134050006-134050007(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050053-134050054(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050059-134050060(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050088-134050089(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050206-134050207(-) m6A 3'UTR       26404942//27371828
chr8:134050221-134050222(-) m6A 3'UTR       26404942//27371828
chr8:134050236-134050237(-) m6A 3'UTR       26404942//27371828
chr8:134050269-134050270(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050292-134050293(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050348-134050349(-) m6A 3'UTR       25456834//26404942//27371828
chr8:134050382-134050383(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050411-134050412(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050421-134050422(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050426-134050427(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050441-134050442(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050473-134050474(-) m6A 3'UTR       25456834//24981863//26404942//27371828
chr8:134050551-134050552(-) m6A 3'UTR//exon       26404942//27371828
chr8:134050591-134050592(-) m6A 3'UTR//exon       26404942
chr8:134050633-134050634(-) m6A 3'UTR//exon       26404942
chr8:134050732-134050733(-) m6A 3'UTR//exon       26404942
chr8:134050761-134050762(-) m6A 3'UTR//exon       26404942
chr8:134050772-134050773(-) m6A CDS//exon       26404942//27371828
chr8:134050871-134050872(-) m6A CDS//exon       26404942
chr8:134061024-134061025(-) m6A exon//intron       26404942
chr8:134061029-134061030(-) m6A exon//intron       26404942
chr8:134061117-134061118(-) m6A exon//intron       26404942
chr8:134061146-134061147(-) m6A exon//intron       26404942
chr8:134061176-134061177(-) m6A exon//intron       26404942
chr8:134061205-134061206(-) m6A exon//intron       26404942
chr8:134062080-134062081(-) m6A exon//intron       26404942
chr8:134071334-134071335(-) m6A CDS//intron       27371828
chr8:134072397-134072398(-) m6A CDS//exon//intron       27371828
chr8:134072513-134072514(-) m6A CDS//exon//intron       26404942//27371828
chr8:134072568-134072569(-) m6A 5'UTR//intron       26404942
chr8:134075846-134075847(-) m6A 5'UTR//intron       26404942
chr8:134075856-134075857(-) m6A 5'UTR//intron       26404942
chr8:134087131-134087132(-) m6A 5'UTR//exon//intron       27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SLA
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10a-3p
Interactor2: SLA

Evidence Support:


Strong-Evidence 3'UTR indicator assay
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells Interactor2 expression None
Description We focused this analysis mostly on 3'UTRs of mRNAs encoding proteins with functions of potential relevance to KSHV biology and pathogenesis (Table S11). Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).

Starting a new search, please wait ...