Basic Information:

  VIRBase ID:  

VHID00423614

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:  MIMAT0002179          PRKAB2:  NR_103871     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-3p	PRKAB2
miRBase Accession/Entrez ID	MIMAT0002179	5565
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRKAB2	chr1:146629519-146629520(-) m6A 3'UTR       22608085 chr1:146629527-146629528(-) m6A 3'UTR       22608085 chr1:146629635-146629636(-) m6A 3'UTR       22608085 chr1:146630465-146630466(-) m6A 3'UTR       27773535 chr1:146630517-146630518(-) m6A 3'UTR       27773535 chr1:146630595-146630596(-) m6A 3'UTR       27773535 chr1:146631065-146631066(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr1:146631081-146631082(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr1:146631086-146631087(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr1:146632403-146632404(-) m6A exon//intron       24209618 chr1:146633315-146633316(-) m6A CDS//exon       24209618//27773535 chr1:146634031-146634032(-) m6A CDS//exon       27773535 chr1:146638088-146638089(-) m6A CDS//exon       27773535 chr1:146639465-146639466(-) m6A CDS//intron       27773536 chr1:146639501-146639502(-) m6A CDS//intron       27371828//27773536 chr1:146643715-146643716(-) m6A CDS//exon       24284625//24981863//27371828//27773536 chr1:146644054-146644055(-) m6A 5'UTR//exon       24209618//24981863//27773536//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PRKAB2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-3p
Interactor2: PRKAB2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.