Detail Information

Basic Information:


  VIRBase ID:  

VHID00423397

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9512

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:           IL6ST:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10a-3p IL6ST
miRBase
Accession/Entrez ID		 MIMAT0002179 3572
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - CD130//CDW130//GP130//HIES4//IL-6RB//sGP130

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IL6ST
chr5:55256638(-) A-I      intronic
chr5:55249408(-) A-I      intronic
chr5:55249478(-) A-I      intronic
chr5:55281259(-) A-I      intronic
chr5:55281245(-) A-I      intronic
chr5:55257423(-) A-I      intronic
chr5:55241678(-) A-I      intronic
chr5:55256634(-) A-I      intronic
chr5:55281233(-) A-I      intronic
chr5:55241607(-) A-I      intronic
chr5:55281099(-) A-I      intronic
chr5:55279080(-) A-I      intronic
chr5:55278966(-) A-I      intronic
chr5:55276830(-) A-I      intronic
chr5:55275055(-) A-I      intronic
chr5:55275016(-) A-I      intronic
chr5:55275003(-) A-I      intronic
chr5:55270935(-) A-I      intronic
chr5:55251249(-) A-I      intronic
chr5:55249481(-) A-I      intronic
chr5:55248791(-) A-I      intronic
chr5:55248751(-) A-I      intronic
chr5:55248723(-) A-I      intronic
chr5:55268829(-) A-I      intronic
chr5:55251163(-) A-I      intronic
chr5:55268616(-) A-I      intronic
chr5:55248807(-) A-I      intronic
chr5:55242910(-) A-I      intronic
chr5:55242900(-) A-I      intronic
chr5:55253475(-) A-I      intronic
chr5:55242892(-) A-I      intronic
chr5:55268824(-) A-I      intronic
chr5:55241564(-) A-I      intronic
chr5:55268278(-) A-I      intronic
chr5:55263794(-) A-I      intronic
chr5:55263780(-) A-I      intronic
chr5:55263761(-) A-I      intronic
chr5:55257474(-) A-I      intronic
chr5:55241655(-) A-I      intronic
chr5:55241541(-) A-I      intronic
chr5:55258677(-) A-I      intronic
chr5:55257504(-) A-I      intronic
chr5:55257503(-) A-I      intronic
chr5:55239819(-) A-I      intronic
chr5:55241650(-) A-I      intronic
chr5:55256715(-) A-I      intronic
chr5:55241627(-) A-I      intronic
chr5:55241600(-) A-I      intronic
chr5:55241617(-) A-I      intronic
chr5:55249691(-) A-I      intronic
chr5:55249486(-) A-I      intronic
chr5:55257403(-) A-I      intronic
chr5:55249409(-) A-I      intronic
chr5:55257360(-) A-I      intronic
chr5:55256732(-) A-I      intronic
chr5:55256731(-) A-I      intronic
chr5:55253511(-) A-I      intronic
chr5:55257467(-) A-I      intronic
chr5:55249366(-) A-I      intronic
chr5:55248826(-) A-I      intronic
chr5:55263784(-) A-I      intronic
chr5:55239905(-) A-I      intronic
chr5:55249388(-) A-I      intronic
chr5:55258866(-) A-I      intronic
chr5:55275015(-) A-I      intronic
chr5:55257326(-) A-I      intronic
chr5:55276807(-) A-I      intronic
chr5:55249314(-) A-I      intronic
chr5:55263788(-) A-I      intronic
chr5:55242501(-) A-I      intronic
chr5:55249677(-) A-I      intronic
chr5:55268576(-) A-I      intronic
chr5:55249661(-) A-I      intronic
chr5:55249315(-) A-I      intronic
chr5:55251161(-) A-I      intronic
chr5:55241648(-) A-I      intronic
chr5:55248687(-) A-I      intronic
chr5:55281175(-) A-I      intronic
chr5:55249446(-) A-I      intronic
chr5:55254523(-) A-I      intronic
chr5:55268159(-) A-I      intronic
chr5:55252829(-) A-I      intronic
chr5:55268667(-) A-I      intronic
chr5:55241546(-) A-I      intronic
chr5:55239784(-) A-I      intronic
chr5:55249364(-) A-I      intronic
chr5:55249387(-) A-I      intronic
chr5:55267482(-) A-I      intronic
chr5:55256541(-) A-I      intronic
chr5:55241653(-) A-I      intronic
chr5:55248660(-) A-I      intronic
chr5:55242964(-) A-I      intronic
chr5:55273194(-) A-I      intronic
chr5:55257517(-) A-I      intronic
chr5:55281087(-) A-I      intronic
chr5:55256622(-) A-I      intronic
chr5:55253970(-) A-I      intronic
chr5:55241750(-) A-I      intronic
chr5:55249573(-) A-I      intronic
chr5:55263654(-) A-I      intronic
chr5:55251153(-) A-I      intronic
chr5:55268151(-) A-I      intronic
chr5:55249746(-) A-I      intronic
chr5:55249280(-) A-I      intronic
chr5:55254493(-) A-I      intronic
chr5:55241659(-) A-I      intronic
chr5:55242916(-) A-I      intronic
chr5:55276757(-) A-I      intronic
chr5:55239873(-) A-I      intronic
chr5:55245069(-) A-I      intronic
chr5:55257542(-) A-I      intronic
chr5:55249495(-) A-I      intronic
chr5:55276849(-) A-I      intronic
chr5:55270294(-) A-I      intronic
chr5:55249651(-) A-I      intronic
chr5:55239823(-) A-I      intronic
chr5:55281158(-) A-I      intronic
chr5:55270507(-) A-I      intronic
chr5:55249784(-) A-I      intronic
chr5:55249693(-) A-I      intronic
chr5:55273570(-) A-I      intronic
chr5:55273572(-) A-I      intronic
chr5:55242609(-) A-I      intronic
chr5:55242799(-) A-I      intronic
chr5:55241706(-) A-I      intronic
chr5:55241658(-) A-I      intronic
chr5:55257547(-) A-I      intronic
chr5:55277286(-) A-I      intronic
chr5:55241662(-) A-I      intronic
chr5:55256635(-) A-I      intronic
chr5:55249779(-) A-I      intronic
chr5:55281084(-) A-I      intronic
chr5:55241711(-) A-I      intronic
chr5:55248780(-) A-I      intronic
chr5:55257356(-) A-I      intronic
chr5:55242975(-) A-I      intronic
chr5:55257320(-) A-I      intronic
chr5:55249572(-) A-I      intronic
chr5:55249385(-) A-I      intronic
chr5:55241657(-) A-I      intronic
chr5:55283802(-) A-I      intronic
chr5:55249739(-) A-I      intronic
chr5:55256869(-) A-I      intronic
chr5:55278930(-) A-I      intronic
chr5:55248806(-) A-I      intronic
chr5:55249355(-) A-I      intronic
chr5:55281177(-) A-I      intronic
chr5:55270942(-) A-I      intronic
chr5:55281118(-) A-I      intronic
chr5:55254036(-) A-I      intronic
chr5:55249378(-) A-I      intronic
chr5:55249323(-) A-I      intronic
chr5:55270609(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IL6ST
chr5:55249739(-) A-I intron -    21960545   //22327324
chr5:55253477(-) A-I intron -    22327324
chr5:55249733(-) A-I intron -    21960545
chr5:55249784(-) A-I intron -    21960545
chr5:55254804(-) A-I intron -    21960545
chr5:55270848(-) A-I intron -    21960545
chr5:55253615(-) A-G intron -    22484847
chr5:55239806(-) A-G intron -    22484847
chr5:55246569(-) T-C intron -    22484847
chr5:55248806(-) A-G intron -    22484847
chr5:55249314(-) A-G intron -    22484847
chr5:55249315(-) A-G intron -    22484847
chr5:55249323(-) A-G intron -    22484847
chr5:55249355(-) A-G intron -    22484847
chr5:55249356(-) A-G intron -    22484847
chr5:55249378(-) A-G intron -    22484847
chr5:55249382(-) A-G intron -    22484847
chr5:55249387(-) A-G intron -    22484847
chr5:55249451(-) A-G intron -    22484847
chr5:55249495(-) A-G intron -    22484847
chr5:55249573(-) A-G intron -    22484847
chr5:55249599(-) A-G intron -    22484847
chr5:55249661(-) A-G intron -    22484847
chr5:55249667(-) A-G intron -    22484847
chr5:55249675(-) A-G intron -    22484847
chr5:55249677(-) A-G intron -    22484847
chr5:55249693(-) A-G intron -    22484847
chr5:55249739(-) A-G intron -    22484847
chr5:55249784(-) A-G intron -    22484847
chr5:55254523(-) A-G intron -    22484847
chr5:55256582(-) A-G intron -    22484847
chr5:55256704(-) A-G intron -    22484847
chr5:55256861(-) C-T intron -    22484847
chr5:55256869(-) A-G intron -    22484847
chr5:55257356(-) A-G intron -    22484847
chr5:55257394(-) A-G intron -    22484847
chr5:55257547(-) A-G intron -    22484847
chr5:55262896(-) G-A intron -    22484847
chr5:55268151(-) A-G intron -    22484847
chr5:55270306(-) A-G intron -    22484847
chr5:55270507(-) A-G intron -    22484847
chr5:55270848(-) A-G intron -    22484847
chr5:55270942(-) A-G intron -    22484847
chr5:55273194(-) A-G intron -    22484847
chr5:55273570(-) A-G intron -    22484847
chr5:55273572(-) A-G intron -    22484847
chr5:55275015(-) A-G intron -    22484847
chr5:55276757(-) A-G intron -    22484847
chr5:55277286(-) A-G intron -    22484847
chr5:55281262(-) A-G intron -    22484847
chr5:55253477(-) A-G intron -    22484847
chr5:55253535(-) A-G intron -    22484847
chr5:55254780(-) A-G intron -    22484847
chr5:55254804(-) A-G intron -    22484847
chr5:55254841(-) A-G intron -    22484847
chr5:55254850(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IL6ST
chr5:55231354-55231355(-) m6A 3'UTR       27773535
chr5:55231396-55231397(-) m6A 3'UTR       24981863//27773535
chr5:55231462-55231463(-) m6A 3'UTR       27773535
chr5:55231479-55231480(-) m6A 3'UTR       27773535
chr5:55234704-55234705(-) m6A 3'UTR       24981863
chr5:55234742-55234743(-) m6A 3'UTR       24981863
chr5:55234771-55234772(-) m6A 3'UTR       24981863
chr5:55234823-55234824(-) m6A 3'UTR       26404942
chr5:55235756-55235757(-) m6A 3'UTR       27773535
chr5:55235761-55235762(-) m6A 3'UTR       27773535
chr5:55235766-55235767(-) m6A 3'UTR       27773535
chr5:55235790-55235791(-) m6A 3'UTR       27773535
chr5:55235909-55235910(-) m6A 3'UTR       27773535
chr5:55235932-55235933(-) m6A 3'UTR       27773535
chr5:55236036-55236037(-) m6A 3'UTR       27773535
chr5:55236065-55236066(-) m6A 3'UTR       27773535
chr5:55236129-55236130(-) m6A 3'UTR       27773535
chr5:55236472-55236473(-) m6A 3'UTR       26404942//27773535
chr5:55236503-55236504(-) m6A 3'UTR       26404942//27773535
chr5:55236593-55236594(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236617-55236618(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236644-55236645(-) m6A 3'UTR       24981863//27773535//22608085
chr5:55236693-55236694(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236710-55236711(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236776-55236777(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236786-55236787(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr5:55236905-55236906(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55236941-55236942(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55236998-55236999(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55237017-55237018(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr5:55237119-55237120(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr5:55237125-55237126(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr5:55237213-55237214(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr5:55237218-55237219(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr5:55237362-55237363(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr5:55237411-55237412(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr5:55237497-55237498(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr5:55237531-55237532(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr5:55238569-55238570(-) m6A 3'UTR//CDS//exon       27773535
chr5:55243323-55243324(-) m6A 3'UTR//CDS//exon//intron       27773535
chr5:55244757-55244758(-) m6A exon//intron       27773535
chr5:55251961-55251962(-) m6A 3'UTR//CDS//exon//intron       26404942
chr5:55256332-55256333(-) m6A CDS//intron       26404942
chr5:55259205-55259206(-) m6A CDS//intron       26404942
chr5:55259259-55259260(-) m6A CDS//intron       26404942
chr5:55278598-55278599(-) m6A 5'UTR//exon//intron       27773536
chr5:55278634-55278635(-) m6A 5'UTR//exon//intron       27773536//22575960
chr5:55290711-55290712(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IL6ST
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10a-3p
Interactor2: IL6ST

Evidence Support:


Strong-Evidence Luciferase reporter assay//Western blot
Weak-Evidence HITS-CLIP
Prediction-Evidence cRep//miRanda
Support Database RepTar//VmiReg

References:


PMID 22927820 Target region None
Source RepTar//VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description The vIL-6 reporter was inhibited in a dose-dependent manner up to 40% in the presence of miR-K12-10.

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