Basic Information:

  VIRBase ID:  

VHID00423255

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10a-3p:  MIMAT0002179          EIF4A1:  NM_001416     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10a-3p	EIF4A1
miRBase Accession/Entrez ID	MIMAT0002179	1973
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DDX2A//EIF-4A//eIF-4A-I//EIF4A//eIF4A-I

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF4A1	chr17:7479492(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF4A1	chr17:7476026-7476027(+) m6A 5'UTR       24981863 chr17:7476079-7476080(+) m6A 5'UTR       24981863 chr17:7476660-7476661(+) m6A 5'UTR//intron       24284625//25456834//24981863//22575960 chr17:7476818-7476819(+) m6A 5'UTR//CDS//exon//intron       - chr17:7477551-7477552(+) m6A 5'UTR//intron       25456834//24981863 chr17:7477556-7477557(+) m6A 5'UTR//intron       25456834//24981863 chr17:7477569-7477570(+) m6A 5'UTR//intron       25456834//24981863 chr17:7477585-7477586(+) m6A 5'UTR//CDS//exon//intron       25456834//24981863//26404942//27773535 chr17:7477631-7477632(+) m6A exon//intron       25456834//24981863 chr17:7477903-7477904(+) m6A 3'UTR//CDS//exon//intron       - chr17:7478146-7478147(+) Tm exon//intron       - chr17:7479291-7479292(+) m6A exon//intron       - chr17:7479314-7479315(+) m6A exon//intron       - chr17:7479869-7479870(+) m6A 3'UTR//CDS//exon//intron       22575960 chr17:7479933-7479934(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr17:7480180-7480181(+) Tm exon//intron       - chr17:7480439-7480440(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7480725-7480726(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr17:7480899-7480900(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7480922-7480923(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7480974-7480975(+) m6A 3'UTR//CDS//exon       26404942//27773535//22575960 chr17:7481098-7481099(+) m6A 3'UTR//exon//intron       26404942//27773535//22575960 chr17:7481157-7481158(+) m6A 3'UTR//CDS//exon       26404942//27773535//22575960 chr17:7481247-7481248(+) m6A 3'UTR//exon//intron       26404942//27773535//22575960 chr17:7481299-7481300(+) m6A 3'UTR//exon//intron       27773535 chr17:7481375-7481376(+) Tm 3'UTR//exon//intron       - chr17:7481549-7481550(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr17:7481579-7481580(+) m6A exon//intron       27773535 chr17:7481721-7481722(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7481729-7481730(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7481739-7481740(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7481747-7481748(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr17:7481895-7481896(+) m6A 3'UTR//exon       24981863//27773535//22575960 chr17:7481951-7481952(+) m6A 3'UTR       24981863//27773535 chr17:7481958-7481959(+) m6A 3'UTR       24981863//27773535 chr17:7481967-7481968(+) m6A 3'UTR       24981863//27773535 chr17:7482033-7482034(+) m6A 3'UTR       27773535 chr17:7482121-7482122(+) m6A 3'UTR       27773535//22575960 chr17:7482148-7482149(+) m6A 3'UTR       27773535//22575960 chr17:7482166-7482167(+) m6A 3'UTR       27773535//22575960 chr17:7482175-7482176(+) m6A 3'UTR       27773535//22575960 chr17:7482284-7482285(+) m6A 3'UTR       27773535 chr17:7482318-7482319(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EIF4A1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10a-3p
Interactor2: EIF4A1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Of the 36 miRNA-3'UTR pairs, 28 showed significant downregulation of 3'UTR indicator activity.