Basic Information:

  VIRBase ID:  

VHID00422471

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6061

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          ATP11C:  NM_001353811     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	ATP11C
miRBase Accession/Entrez ID	MIMAT0010132	286410
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ATPIG//ATPIQ//HACXL

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP11C	chrX:138917734(-) A-I      intronic chrX:138906724(-) A-I      intronic chrX:138904494(-) A-I      intronic chrX:138904480(-) A-I      intronic chrX:138904477(-) A-I      intronic chrX:138872286(-) A-I      intronic chrX:138860310(-) A-I      intronic chrX:138843778(-) A-I      intronic chrX:138843740(-) A-I      intronic chrX:138843251(-) A-I      intronic chrX:138988481(-) A-I      intronic chrX:138988494(-) A-I      intronic chrX:138988507(-) A-I      intronic chrX:138957923(-) A-I      intronic chrX:138957922(-) A-I      intronic chrX:138957900(-) A-I      intronic chrX:138957879(-) A-I      intronic chrX:138956177(-) A-I      intronic chrX:138956176(-) A-I      intronic chrX:138956172(-) A-I      intronic chrX:138956150(-) A-I      intronic chrX:138956149(-) A-I      intronic chrX:138891292(-) A-I      intronic chrX:138891291(-) A-I      intronic chrX:138955648(-) A-I      intronic chrX:138981553(-) A-I      intronic chrX:138891236(-) A-I      intronic chrX:138891258(-) A-I      intronic chrX:138891266(-) A-I      intronic chrX:138891272(-) A-I      intronic chrX:138904488(-) A-I      intronic chrX:138904516(-) A-I      intronic chrX:138904520(-) A-I      intronic chrX:138988446(-) A-I      intronic chrX:138988448(-) A-I      intronic chrX:138988460(-) A-I      intronic chrX:138988468(-) A-I      intronic chrX:138988489(-) A-I      intronic chrX:138988508(-) A-I      intronic chrX:138992702(-) A-I      intronic chrX:138992682(-) A-I      intronic chrX:138991547(-) A-I      intronic chrX:138991374(-) A-I      intronic chrX:138991359(-) A-I      intronic chrX:139005091(-) A-I      intronic chrX:139005124(-) A-I      intronic chrX:138991358(-) A-I      intronic chrX:138988543(-) A-I      intronic chrX:138988524(-) A-I      intronic chrX:139001570(-) A-I      intronic chrX:139005085(-) A-I      intronic chrX:139001565(-) A-I      intronic chrX:139001564(-) A-I      intronic chrX:139001280(-) A-I      intronic chrX:139001274(-) A-I      intronic chrX:139005161(-) A-I      intronic chrX:139005162(-) A-I      intronic chrX:139005163(-) A-I      intronic chrX:139005172(-) A-I      intronic chrX:139005191(-) A-I      intronic chrX:139005195(-) A-I      intronic chrX:139001189(-) A-I      intronic chrX:139001141(-) A-I      intronic chrX:138860905(-) A-I      intronic chrX:138977567(-) A-I      intronic chrX:138977605(-) A-I      intronic chrX:138977606(-) A-I      intronic chrX:138977623(-) A-I      intronic chrX:138978106(-) A-I      intronic chrX:138978109(-) A-I      intronic chrX:138978840(-) A-I      intronic chrX:138978898(-) A-I      intronic chrX:138978934(-) A-I      intronic chrX:138978945(-) A-I      intronic chrX:138979658(-) A-I      intronic chrX:138979667(-) A-I      intronic chrX:138979778(-) A-I      intronic chrX:138979796(-) A-I      intronic chrX:138979824(-) A-I      intronic chrX:138981550(-) A-I      intronic chrX:138981560(-) A-I      intronic chrX:138981573(-) A-I      intronic chrX:138988476(-) A-I      intronic chrX:138955632(-) A-I      intronic chrX:138955622(-) A-I      intronic chrX:138955610(-) A-I      intronic chrX:138953855(-) A-I      intronic chrX:138953569(-) A-I      intronic chrX:138953567(-) A-I      intronic chrX:138953531(-) A-I      intronic chrX:138953103(-) A-I      intronic chrX:138953051(-) A-I      intronic chrX:138951823(-) A-I      intronic chrX:138918051(-) A-I      intronic chrX:138918038(-) A-I      intronic chrX:138977558(-) A-I      intronic chrX:138977152(-) A-I      intronic chrX:138977133(-) A-I      intronic chrX:138974302(-) A-I      intronic chrX:138974216(-) A-I      intronic chrX:138974195(-) A-I      intronic chrX:138974194(-) A-I      intronic chrX:138972659(-) A-I      intronic chrX:138972609(-) A-I      intronic chrX:138972502(-) A-I      intronic chrX:138972487(-) A-I      intronic chrX:138971239(-) A-I      intronic chrX:138971142(-) A-I      intronic chrX:138971107(-) A-I      intronic chrX:138970579(-) A-I      intronic chrX:138970554(-) A-I      intronic chrX:138970543(-) A-I      intronic chrX:138969964(-) A-I      intronic chrX:138969927(-) A-I      intronic chrX:138969760(-) A-I      intronic chrX:138969704(-) A-I      intronic chrX:138969692(-) A-I      intronic chrX:138969687(-) A-I      intronic chrX:138969665(-) A-I      intronic chrX:138969615(-) A-I      intronic chrX:138969612(-) A-I      intronic chrX:138966701(-) A-I      intronic chrX:138956299(-) A-I      intronic chrX:138955758(-) A-I      intronic chrX:138955743(-) A-I      intronic chrX:138955649(-) A-I      intronic chrX:138917661(-) A-I      intronic chrX:138970468(-) A-I      intronic chrX:139005084(-) A-I      intronic chrX:138974154(-) A-I      intronic chrX:138977602(-) A-I      intronic chrX:138970529(-) A-I      intronic chrX:138843739(-) A-I      intronic chrX:138971064(-) A-I      intronic chrX:138953640(-) A-I      intronic chrX:138917626(-) A-I      intronic chrX:138882097(-) A-I      intronic chrX:138971199(-) A-I      intronic chrX:138978941(-) A-I      intronic chrX:138968624(-) A-I      intronic chrX:138930805(-) A-I      intronic chrX:138891106(-) A-I      intronic chrX:138953504(-) A-I      intronic chrX:138994169(-) A-I      intronic chrX:139001183(-) A-I      intronic chrX:138968704(-) A-I      intronic chrX:138969872(-) A-I      intronic chrX:138969967(-) A-I      intronic chrX:138894850(-) A-I      intronic chrX:139000032(-) A-I      intronic chrX:139000759(-) A-I      intronic chrX:138970563(-) A-I      intronic chrX:138978933(-) A-I      intronic chrX:138970534(-) A-I      intronic chrX:138974153(-) A-I      intronic chrX:138953550(-) A-I      intronic chrX:138977594(-) A-I      intronic chrX:138977568(-) A-I      intronic chrX:138977508(-) A-I      intronic chrX:138969885(-) A-I      intronic chrX:138953572(-) A-I      intronic chrX:138953808(-) A-I      intronic chrX:138953505(-) A-I      intronic chrX:138953397(-) A-I      intronic chrX:138969529(-) A-I      intronic chrX:138872494(-) A-I      intronic chrX:138953931(-) A-I      intronic chrX:138955745(-) A-I      intronic chrX:138958719(-) A-I      intronic chrX:138977179(-) A-I      intronic chrX:138953864(-) A-I      intronic chrX:138971204(-) A-I      intronic chrX:138991564(-) A-I      intronic chrX:138957771(-) A-I      intronic chrX:138969982(-) A-I      intronic chrX:138972608(-) A-I      intronic chrX:138917715(-) A-I      intronic chrX:138969581(-) A-I      intronic chrX:138955779(-) A-I      intronic chrX:138951744(-) A-I      intronic chrX:138988540(-) A-I      intronic chrX:138929831(-) A-I      intronic chrX:138980039(-) A-I      intronic chrX:139005044(-) A-I      intronic chrX:138970542(-) A-I      intronic chrX:138970562(-) A-I      intronic chrX:138991559(-) A-I      intronic chrX:138953641(-) A-I      intronic chrX:138955783(-) A-I      intronic chrX:138955804(-) A-I      intronic chrX:139001507(-) A-I      intronic chrX:138917728(-) A-I      intronic chrX:138860100(-) A-I      intronic chrX:138917656(-) A-I      intronic chrX:138969884(-) A-I      intronic chrX:138970557(-) A-I      intronic chrX:139001544(-) A-I      intronic chrX:138955704(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP11C	chrX:138839970(-) A-C exon CDS    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP11C	chrX:138809329-138809330(-) Cm 3'UTR       - chrX:138856954-138856955(-) m6A CDS//exon       24981863 chrX:138856967-138856968(-) m6A CDS//exon       24981863 chrX:138856987-138856988(-) m6A CDS//exon       24981863 chrX:138857026-138857027(-) m6A CDS//exon       24981863 chrX:138871487-138871488(-) Am CDS//exon       - chrX:139014755-139014756(-) m6A 5'UTR//intron       27371828//27773536 chrX:139014844-139014845(-) m6A 5'UTR//intron       24209618//27371828//27773536 chrX:139014875-139014876(-) m6A 5'UTR//intron       24209618//27371828//27773536 chrX:139015038-139015039(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22608085 chrX:139015076-139015077(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22608085 chrX:139015134-139015135(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ATP11C	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: ATP11C

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.