Detail Information

Basic Information:


  VIRBase ID:  

VHID00422045

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:           EXOC8:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART22 EXOC8
miRBase
Accession/Entrez ID		 MIMAT0010132 149371
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - EXO84//Exo84p//NEDMISB//SEC84

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EXOC8
chr1:231470972(-) A-I      3'UTR
chr1:231470953(-) A-I      3'UTR
chr1:231470940(-) A-I      3'UTR
chr1:231470904(-) A-I      3'UTR
chr1:231470789(-) A-I      3'UTR
chr1:231470820(-) A-I      3'UTR
chr1:231470858(-) A-I      3'UTR
chr1:231470886(-) A-I      3'UTR
chr1:231470891(-) A-I      3'UTR
chr1:231470846(-) A-I      3'UTR
chr1:231470864(-) A-I      3'UTR
chr1:231470929(-) A-I      3'UTR
chr1:231470874(-) A-I      3'UTR
chr1:231470871(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EXOC8
chr1:231470998(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EXOC8
chr1:231468613-231468614(-) m6A 3'UTR       27773535
chr1:231470533-231470534(-) m6A 3'UTR       22608085
chr1:231470608-231470609(-) m6A 3'UTR       24981863//22608085
chr1:231470644-231470645(-) m6A 3'UTR       24981863//22608085
chr1:231470866-231470867(-) m6A 3'UTR       27773535
chr1:231470981-231470982(-) m6A 3'UTR       24284625//27773535
chr1:231471216-231471217(-) m6A 3'UTR       27773535
chr1:231471355-231471356(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471394-231471395(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471441-231471442(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231471466-231471467(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231471625-231471626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471656-231471657(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471755-231471756(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471790-231471791(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr1:231471842-231471843(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231471883-231471884(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472083-231472084(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:231472190-231472191(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chr1:231472300-231472301(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472357-231472358(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472381-231472382(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472400-231472401(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472436-231472437(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472463-231472464(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr1:231472499-231472500(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472534-231472535(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472541-231472542(-) m1A CDS       26863410
chr1:231472655-231472656(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472745-231472746(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472763-231472764(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr1:231472907-231472908(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472928-231472929(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231472951-231472952(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr1:231473099-231473100(-) m6A CDS       24284625//27371828//27773536//22608085
chr1:231473294-231473295(-) m6A CDS       24284625//24981863//27371828//27773536//22608085
chr1:231473318-231473319(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr1:231473372-231473373(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473378-231473379(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473471-231473472(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473502-231473503(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr1:231473548-231473549(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EXOC8
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART22
Interactor2: EXOC8

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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