Basic Information:

  VIRBase ID:  

VHID00421436

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          STARD3NL:  NM_001363347     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	STARD3NL
miRBase Accession/Entrez ID	MIMAT0010132	83930
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MENTHO

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STARD3NL	chr7:38259446(+) A-I      intronic chr7:38259451(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STARD3NL	chr7:38261010(+) A-G intron -    22484847 chr7:38241436(+) G-C intron -    22484847 chr7:38241437(+) C-T intron -    22484847 chr7:38241438(+) A-T intron -    22484847 chr7:38259413(+) A-G intron -    22484847 chr7:38259419(+) A-G intron -    22484847 chr7:38259447(+) A-G intron -    22484847 chr7:38260934(+) A-G intron -    22484847 chr7:38260936(+) A-G intron -    22484847 chr7:38260937(+) A-G intron -    22484847 chr7:38260943(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STARD3NL	chr7:38217911-38217912(+) m6A 5'UTR       24981863 chr7:38218009-38218010(+) m6A 5'UTR//exon       24981863 chr7:38247109-38247110(+) m6A CDS//exon       24284625 chr7:38247124-38247125(+) m6A CDS//exon       24284625 chr7:38247264-38247265(+) m6A CDS//exon       24284625//24981863//27773535 chr7:38253976-38253977(+) m6A CDS//exon       27773535 chr7:38269714-38269715(+) Y 3'UTR//exon       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	STARD3NL	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: STARD3NL

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.