Detail Information

Basic Information:


  VIRBase ID:  

VHID00421347

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:           DDHD1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART22 DDHD1
miRBase
Accession/Entrez ID		 MIMAT0010132 80821
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - iPLA1alpha//PA-PLA1//PAPLA1//SPG28

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DDHD1
chr14:53516826(-) A-I      intronic
chr14:53516830(-) A-I      intronic
chr14:53517244(-) A-I      intronic
chr14:53517227(-) A-I      intronic
chr14:53517210(-) A-I      intronic
chr14:53517274(-) A-I      intronic
chr14:53517228(-) A-I      intronic
chr14:53517201(-) A-I      intronic
chr14:53516857(-) A-I      intronic
chr14:53516856(-) A-I      intronic
chr14:53517262(-) A-I      intronic
chr14:53517243(-) A-I      intronic
chr14:53516844(-) A-I      intronic
chr14:53516834(-) A-I      intronic
chr14:53579838(-) A-I      intronic
chr14:53589993(-) A-I      intronic
chr14:53533107(-) A-I      intronic
chr14:53533049(-) A-I      intronic
chr14:53526499(-) A-I      intronic
chr14:53612105(-) A-I      intronic
chr14:53526470(-) A-I      intronic
chr14:53526402(-) A-I      intronic
chr14:53535168(-) A-I      intronic
chr14:53547547(-) A-I      intronic
chr14:53590098(-) A-I      intronic
chr14:53593259(-) A-I      intronic
chr14:53612139(-) A-I      intronic
chr14:53590099(-) A-I      intronic
chr14:53590059(-) A-I      intronic
chr14:53590141(-) A-I      intronic
chr14:53592558(-) A-I      intronic
chr14:53526101(-) A-I      intronic
chr14:53592670(-) A-I      intronic
chr14:53526091(-) A-I      intronic
chr14:53526087(-) A-I      intronic
chr14:53606398(-) A-I      intronic
chr14:53604878(-) A-I      intronic
chr14:53534352(-) A-I      intronic
chr14:53533121(-) A-I      intronic
chr14:53533034(-) A-I      intronic
chr14:53533992(-) A-I      intronic
chr14:53592503(-) A-I      intronic
chr14:53549161(-) A-I      intronic
chr14:53534261(-) A-I      intronic
chr14:53593223(-) A-I      intronic
chr14:53534073(-) A-I      intronic
chr14:53574446(-) A-I      intronic
chr14:53547564(-) A-I      intronic
chr14:53533083(-) A-I      intronic
chr14:53533086(-) A-I      intronic
chr14:53534268(-) A-I      intronic
chr14:53592692(-) A-I      intronic
chr14:53534426(-) A-I      intronic
chr14:53534313(-) A-I      intronic
chr14:53534447(-) A-I      intronic
chr14:53546979(-) A-I      intronic
chr14:53570912(-) A-I      intronic
chr14:53533537(-) A-I      intronic
chr14:53579052(-) A-I      intronic
chr14:53574336(-) A-I      intronic
chr14:53533973(-) A-I      intronic
chr14:53574343(-) A-I      intronic
chr14:53574426(-) A-I      intronic
chr14:53574427(-) A-I      intronic
chr14:53574465(-) A-I      intronic
chr14:53579053(-) A-I      intronic
chr14:53570947(-) A-I      intronic
chr14:53516813(-) A-I      intronic
chr14:53611633(-) A-I      intronic
chr14:53516818(-) A-I      intronic
chr14:53547555(-) A-I      intronic
chr14:53517231(-) A-I      intronic
chr14:53534108(-) A-I      intronic
chr14:53517259(-) A-I      intronic
chr14:53533048(-) A-I      intronic
chr14:53517242(-) A-I      intronic
chr14:53533633(-) A-I      intronic
chr14:53579884(-) A-I      intronic
chr14:53579011(-) A-I      intronic
chr14:53612145(-) A-I      intronic
chr14:53517278(-) A-I      intronic
chr14:53516795(-) A-I      intronic
chr14:53534383(-) A-I      intronic
chr14:53533052(-) A-I      intronic
chr14:53579818(-) A-I      intronic
chr14:53590705(-) A-I      intronic
chr14:53533522(-) A-I      intronic
chr14:53613004(-) A-I      intronic
chr14:53534059(-) A-I      intronic
chr14:53612134(-) A-I      intronic
chr14:53532966(-) A-I      intronic
chr14:53605141(-) A-I      intronic
chr14:53534041(-) A-I      intronic
chr14:53533116(-) A-I      intronic
chr14:53534448(-) A-I      intronic
chr14:53533030(-) A-I      intronic
chr14:53533602(-) A-I      intronic
chr14:53570940(-) A-I      intronic
chr14:53534441(-) A-I      intronic
chr14:53579091(-) A-I      intronic
chr14:53534340(-) A-I      intronic
chr14:53516561(-) A-I      intronic
chr14:53534357(-) A-I      intronic
chr14:53590793(-) A-I      intronic
chr14:53613212(-) A-I      intronic
chr14:53517229(-) A-I      intronic
chr14:53577459(-) A-I      intronic
chr14:53533519(-) A-I      intronic
chr14:53533585(-) A-I      intronic
chr14:53533949(-) A-I      intronic
chr14:53535175(-) A-I      intronic
chr14:53533467(-) A-I      intronic
chr14:53517200(-) A-I      intronic
chr14:53516855(-) A-I      intronic
chr14:53517272(-) A-I      intronic
chr14:53549579(-) A-I      intronic
chr14:53534065(-) A-I      intronic
chr14:53534354(-) A-I      intronic
chr14:53579846(-) A-I      intronic
chr14:53517281(-) A-I      intronic
chr14:53533112(-) A-I      intronic
chr14:53512141(-) A-I      3'UTR
chr14:53512063(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DDHD1
chr14:53546490(-) A-I intron -    22327324
chr14:53516844(-) A-I intron -    21960545
chr14:53516795(-) A-G intron -    22484847
chr14:53516813(-) A-G intron -    22484847
chr14:53516818(-) A-G intron -    22484847
chr14:53516855(-) A-G intron -    22484847
chr14:53533585(-) A-G intron -    22484847
chr14:53534980(-) C-A intron -    22484847
chr14:53534981(-) T-A intron -    22484847
chr14:53547564(-) A-G intron -    22484847
chr14:53517231(-) A-G intron -    22484847
chr14:53517242(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DDHD1
chr14:53503540-53503541(-) m6A 3'UTR       -
chr14:53503573-53503574(-) m6A 3'UTR       -
chr14:53503626-53503627(-) m6A 3'UTR       -
chr14:53503664-53503665(-) m6A 3'UTR       -
chr14:53503670-53503671(-) m6A 3'UTR       -
chr14:53503679-53503680(-) m6A 3'UTR       -
chr14:53503686-53503687(-) m6A 3'UTR       -
chr14:53503752-53503753(-) m6A 3'UTR       -
chr14:53503759-53503760(-) m6A 3'UTR       -
chr14:53503827-53503828(-) m6A 3'UTR       -
chr14:53503886-53503887(-) m6A 3'UTR       -
chr14:53504103-53504104(-) m6A 3'UTR       -
chr14:53504191-53504192(-) m6A 3'UTR       -
chr14:53504257-53504258(-) m6A 3'UTR       -
chr14:53504278-53504279(-) m6A 3'UTR       -
chr14:53504284-53504285(-) m6A 3'UTR       -
chr14:53504311-53504312(-) m6A 3'UTR       -
chr14:53504327-53504328(-) m6A 3'UTR       -
chr14:53504365-53504366(-) m6A 3'UTR       -
chr14:53504370-53504371(-) m6A 3'UTR       -
chr14:53504406-53504407(-) m6A 3'UTR       -
chr14:53504424-53504425(-) m6A 3'UTR       -
chr14:53504454-53504455(-) m6A 3'UTR       -
chr14:53504474-53504475(-) m6A 3'UTR       -
chr14:53504510-53504511(-) m6A 3'UTR       -
chr14:53504550-53504551(-) m6A 3'UTR       -
chr14:53504572-53504573(-) m6A 3'UTR       -
chr14:53504579-53504580(-) m6A 3'UTR       -
chr14:53510171-53510172(-) m6A 3'UTR       -
chr14:53510249-53510250(-) m6A 3'UTR       -
chr14:53510332-53510333(-) m6A 3'UTR       -
chr14:53510338-53510339(-) m6A 3'UTR       -
chr14:53511857-53511858(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:53511950-53511951(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr14:53511966-53511967(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr14:53512116-53512117(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:53512134-53512135(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:53512157-53512158(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr14:53512294-53512295(-) m6A 3'UTR       24981863
chr14:53512757-53512758(-) m6A 3'UTR//exon       27773535
chr14:53512788-53512789(-) m6A 3'UTR//exon       27773535
chr14:53512822-53512823(-) m6A 3'UTR//exon       27773535
chr14:53512838-53512839(-) m6A 3'UTR//exon       27773535
chr14:53512864-53512865(-) m6A 3'UTR//exon       27773535
chr14:53512877-53512878(-) m6A 3'UTR//exon       27773535
chr14:53512904-53512905(-) m6A 3'UTR//exon       27773535
chr14:53512956-53512957(-) m6A 3'UTR//exon       27773535
chr14:53512967-53512968(-) m6A 3'UTR//exon       27773535
chr14:53512980-53512981(-) m6A 3'UTR//exon       27773535
chr14:53513155-53513156(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr14:53513214-53513215(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr14:53513241-53513242(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr14:53513265-53513266(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr14:53513455-53513456(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr14:53513471-53513472(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr14:53513484-53513485(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr14:53513506-53513507(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr14:53513530-53513531(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr14:53513638-53513639(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr14:53515273-53515274(-) m6A exon//intron       24284625//24981863//22608085
chr14:53522498-53522499(-) m6A CDS//exon       24284625//27773535
chr14:53522534-53522535(-) m6A CDS//exon       24284625//27773535
chr14:53522600-53522601(-) m6A CDS//exon       27773535
chr14:53522615-53522616(-) m6A CDS//exon       27773535
chr14:53525258-53525259(-) m6A CDS//exon       27773535
chr14:53529680-53529681(-) m6A CDS//exon       24981863//27773535
chr14:53529755-53529756(-) m6A CDS//exon       27773535
chr14:53570479-53570480(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr14:53570545-53570546(-) m6A CDS//exon       24284625//24981863//27773535//22608085
chr14:53616533-53616534(-) m6A 5'UTR//intron       24284625//24981863//27773535//22608085
chr14:53618980-53618981(-) m6A CDS//exon       22608085
chr14:53619058-53619059(-) m6A CDS//exon//intron       24284625//27371828
chr14:53619121-53619122(-) m6A CDS//intron       24284625//27371828//27773536
chr14:53619190-53619191(-) m6A CDS//intron       24284625//27371828//27773536//22575960
chr14:53619218-53619219(-) m6A CDS//intron       24284625//27371828//27773536//22575960
chr14:53619230-53619231(-) m6A CDS//intron       24284625//27371828//27773536//22575960
chr14:53619284-53619285(-) m6A CDS//intron       24284625//27371828//27773536
chr14:53619292-53619293(-) m6A CDS//intron       24284625//27371828//27773536
chr14:53619430-53619431(-) m6A CDS       24284625//27371828//27773536
chr14:53619553-53619554(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr14:53619574-53619575(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr14:53619630-53619631(-) m6A CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr14:53619673-53619674(-) m6A CDS       24209618//24981863//27371828//27773536//22608085
chr14:53619838-53619839(-) m6A 5'UTR       24981863//27371828
chr14:53619912-53619913(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DDHD1
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART22
Interactor2: DDHD1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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