Basic Information:

  VIRBase ID:  

VHID00420536

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          RPRD1A:  NM_001303412     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	RPRD1A
miRBase Accession/Entrez ID	MIMAT0010132	55197
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HsT3101//P15RS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RPRD1A	chr18:33610336(-) A-I      intronic chr18:33610334(-) A-I      intronic chr18:33610329(-) A-I      intronic chr18:33610318(-) A-I      intronic chr18:33601901(-) A-I      intronic chr18:33601895(-) A-I      intronic chr18:33596383(-) A-I      intronic chr18:33596379(-) A-I      intronic chr18:33596363(-) A-I      intronic chr18:33578213(-) A-I      intronic chr18:33596355(-) A-I      intronic chr18:33596353(-) A-I      intronic chr18:33578267(-) A-I      intronic chr18:33595340(-) A-I      intronic chr18:33595353(-) A-I      intronic chr18:33634334(-) A-I      intronic chr18:33610338(-) A-I      intronic chr18:33604673(-) A-I      intronic chr18:33583725(-) A-I      intronic chr18:33584385(-) A-I      intronic chr18:33584413(-) A-I      intronic chr18:33584414(-) A-I      intronic chr18:33584421(-) A-I      intronic chr18:33584422(-) A-I      intronic chr18:33596318(-) A-I      intronic chr18:33578199(-) A-I      intronic chr18:33602879(-) A-I      intronic chr18:33610324(-) A-I      intronic chr18:33640284(-) A-I      intronic chr18:33639319(-) A-I      intronic chr18:33639277(-) A-I      intronic chr18:33637523(-) A-I      intronic chr18:33637522(-) A-I      intronic chr18:33637516(-) A-I      intronic chr18:33637480(-) A-I      intronic chr18:33637367(-) A-I      intronic chr18:33636961(-) A-I      intronic chr18:33636452(-) A-I      intronic chr18:33636389(-) A-I      intronic chr18:33636323(-) A-I      intronic chr18:33599128(-) A-I      intronic chr18:33598348(-) A-I      intronic chr18:33597262(-) A-I      intronic chr18:33597218(-) A-I      intronic chr18:33609829(-) A-I      intronic chr18:33596405(-) A-I      intronic chr18:33596389(-) A-I      intronic chr18:33596380(-) A-I      intronic chr18:33596302(-) A-I      intronic chr18:33596282(-) A-I      intronic chr18:33596278(-) A-I      intronic chr18:33595355(-) A-I      intronic chr18:33595352(-) A-I      intronic chr18:33595344(-) A-I      intronic chr18:33595343(-) A-I      intronic chr18:33595308(-) A-I      intronic chr18:33594630(-) A-I      intronic chr18:33594522(-) A-I      intronic chr18:33586453(-) A-I      intronic chr18:33586383(-) A-I      intronic chr18:33586358(-) A-I      intronic chr18:33586270(-) A-I      intronic chr18:33586257(-) A-I      intronic chr18:33585217(-) A-I      intronic chr18:33585207(-) A-I      intronic chr18:33585195(-) A-I      intronic chr18:33585106(-) A-I      intronic chr18:33585043(-) A-I      intronic chr18:33584860(-) A-I      intronic chr18:33584744(-) A-I      intronic chr18:33584398(-) A-I      intronic chr18:33584397(-) A-I      intronic chr18:33578273(-) A-I      intronic chr18:33578153(-) A-I      intronic chr18:33576937(-) A-I      intronic chr18:33576935(-) A-I      intronic chr18:33576927(-) A-I      intronic chr18:33576922(-) A-I      intronic chr18:33599139(-) A-I      intronic chr18:33599106(-) A-I      intronic chr18:33610282(-) A-I      intronic chr18:33610284(-) A-I      intronic chr18:33632729(-) A-I      intronic chr18:33632740(-) A-I      intronic chr18:33632742(-) A-I      intronic chr18:33632745(-) A-I      intronic chr18:33636285(-) A-I      intronic chr18:33578221(-) A-I      intronic chr18:33575294(-) A-I      intronic chr18:33609826(-) A-I      intronic chr18:33604225(-) A-I      intronic chr18:33604212(-) A-I      intronic chr18:33575311(-) A-I      intronic chr18:33575329(-) A-I      intronic chr18:33575425(-) A-I      intronic chr18:33610307(-) A-I      intronic chr18:33594508(-) A-I      intronic chr18:33599275(-) A-I      intronic chr18:33599273(-) A-I      intronic chr18:33599265(-) A-I      intronic chr18:33599248(-) A-I      intronic chr18:33599242(-) A-I      intronic chr18:33575520(-) A-I      intronic chr18:33576905(-) A-I      intronic chr18:33602817(-) A-I      intronic chr18:33610359(-) A-I      intronic chr18:33626612(-) A-I      intronic chr18:33601914(-) A-I      intronic chr18:33632722(-) A-I      intronic chr18:33599182(-) A-I      intronic chr18:33609987(-) A-I      intronic chr18:33629150(-) A-I      intronic chr18:33640213(-) A-I      intronic chr18:33597043(-) A-I      intronic chr18:33602809(-) A-I      intronic chr18:33584278(-) A-I      intronic chr18:33602890(-) A-I      intronic chr18:33632726(-) A-I      intronic chr18:33601770(-) A-I      intronic chr18:33596334(-) A-I      intronic chr18:33599728(-) A-I      intronic chr18:33597161(-) A-I      intronic chr18:33637071(-) A-I      intronic chr18:33596220(-) A-I      intronic chr18:33610256(-) A-I      intronic chr18:33597258(-) A-I      intronic chr18:33601877(-) A-I      intronic chr18:33599855(-) A-I      intronic chr18:33643304(-) A-I      intronic chr18:33584766(-) A-I      intronic chr18:33602842(-) A-I      intronic chr18:33599365(-) A-I      intronic chr18:33594702(-) A-I      intronic chr18:33599981(-) A-I      intronic chr18:33596368(-) A-I      intronic chr18:33596441(-) A-I      intronic chr18:33600733(-) A-I      intronic chr18:33602757(-) A-I      intronic chr18:33604238(-) A-I      intronic chr18:33639247(-) A-I      intronic chr18:33586348(-) A-I      intronic chr18:33602901(-) A-I      intronic chr18:33602669(-) A-I      intronic chr18:33597151(-) A-I      intronic chr18:33576671(-) A-I      intronic chr18:33599989(-) A-I      intronic chr18:33575338(-) A-I      intronic chr18:33596324(-) A-I      intronic chr18:33583840(-) A-I      intronic chr18:33628126(-) A-I      intronic chr18:33588296(-) A-I      intronic chr18:33645458(-) A-I      intronic chr18:33639238(-) A-I      intronic chr18:33638117(-) A-I      intronic chr18:33575366(-) A-I      intronic chr18:33584474(-) A-I      intronic chr18:33601842(-) A-I      intronic chr18:33576879(-) A-I      intronic chr18:33602825(-) A-I      intronic chr18:33584346(-) A-I      intronic chr18:33599260(-) A-I      intronic chr18:33598509(-) A-I      intronic chr18:33599342(-) A-I      intronic chr18:33595238(-) A-I      intronic chr18:33602708(-) A-I      intronic chr18:33601878(-) A-I      intronic chr18:33599881(-) A-I      intronic chr18:33596350(-) A-I      intronic chr18:33584417(-) A-I      intronic chr18:33626736(-) A-I      intronic chr18:33576848(-) A-I      intronic chr18:33597220(-) A-I      intronic chr18:33626722(-) A-I      intronic chr18:33576859(-) A-I      intronic chr18:33597242(-) A-I      intronic chr18:33599811(-) A-I      intronic chr18:33599951(-) A-I      intronic chr18:33594704(-) A-I      intronic chr18:33601791(-) A-I      intronic chr18:33586279(-) A-I      intronic chr18:33597144(-) A-I      intronic chr18:33595314(-) A-I      intronic chr18:33600763(-) A-I      intronic chr18:33643390(-) A-I      intronic chr18:33599751(-) A-I      intronic chr18:33597181(-) A-I      intronic chr18:33588463(-) A-I      intronic chr18:33599209(-) A-I      intronic chr18:33576894(-) A-I      intronic chr18:33596340(-) A-I      intronic chr18:33613001(-) A-I      intronic chr18:33598508(-) A-I      intronic chr18:33597211(-) A-I      intronic chr18:33583900(-) A-I      intronic chr18:33584310(-) A-I      intronic chr18:33599820(-) A-I      intronic chr18:33588417(-) A-I      intronic chr18:33584315(-) A-I      intronic chr18:33599343(-) A-I      intronic chr18:33595354(-) A-I      intronic chr18:33599280(-) A-I      intronic chr18:33602681(-) A-I      intronic chr18:33597107(-) A-I      intronic chr18:33575432(-) A-I      intronic chr18:33597257(-) A-I      intronic chr18:33602754(-) A-I      intronic chr18:33578239(-) A-I      intronic chr18:33610036(-) A-I      intronic chr18:33584783(-) A-I      intronic chr18:33604391(-) A-I      intronic chr18:33599239(-) A-I      intronic chr18:33588443(-) A-I      intronic chr18:33599251(-) A-I      intronic chr18:33602845(-) A-I      intronic chr18:33600739(-) A-I      intronic chr18:33584387(-) A-I      intronic chr18:33610185(-) A-I      intronic chr18:33600725(-) A-I      intronic chr18:33588035(-) A-I      intronic chr18:33575522(-) A-I      intronic chr18:33637544(-) A-I      intronic chr18:33598369(-) A-I      intronic chr18:33599800(-) A-I      intronic chr18:33595380(-) A-I      intronic chr18:33595446(-) A-I      intronic chr18:33595394(-) A-I      intronic chr18:33637386(-) A-I      intronic chr18:33588290(-) A-I      intronic chr18:33634344(-) A-I      intronic chr18:33598365(-) A-I      intronic chr18:33588323(-) A-I      intronic chr18:33588326(-) A-I      intronic chr18:33637571(-) A-I      intronic chr18:33637573(-) A-I      intronic chr18:33599167(-) A-I      intronic chr18:33578280(-) A-I      intronic chr18:33575393(-) A-I      intronic chr18:33584435(-) A-I      intronic chr18:33594512(-) A-I      intronic chr18:33637463(-) A-I      intronic chr18:33588020(-) A-I      intronic chr18:33610191(-) A-I      intronic chr18:33637561(-) A-I      intronic chr18:33576721(-) A-I      intronic chr18:33597124(-) A-I      intronic chr18:33600681(-) A-I      intronic chr18:33595358(-) A-I      intronic chr18:33602838(-) A-I      intronic chr18:33584709(-) A-I      intronic chr18:33576709(-) A-I      intronic chr18:33595369(-) A-I      intronic chr18:33602758(-) A-I      intronic chr18:33626677(-) A-I      intronic chr18:33584852(-) A-I      intronic chr18:33576737(-) A-I      intronic chr18:33578065(-) A-I      intronic chr18:33599921(-) A-I      intronic chr18:33597207(-) A-I      intronic chr18:33604356(-) A-I      intronic chr18:33576755(-) A-I      intronic chr18:33598401(-) A-I      intronic chr18:33637353(-) A-I      intronic chr18:33588439(-) A-I      intronic chr18:33600741(-) A-I      intronic chr18:33604242(-) A-I      intronic chr18:33601727(-) A-I      intronic chr18:33601869(-) A-I      intronic chr18:33640274(-) A-I      intronic chr18:33584473(-) A-I      intronic chr18:33632736(-) A-I      intronic chr18:33604374(-) A-I      intronic chr18:33598420(-) A-I      intronic chr18:33584382(-) A-I      intronic chr18:33637077(-) A-I      intronic chr18:33578245(-) A-I      intronic chr18:33604332(-) A-I      intronic chr18:33578238(-) A-I      intronic chr18:33604248(-) A-I      intronic chr18:33598375(-) A-I      intronic chr18:33597012(-) A-I      intronic chr18:33597217(-) A-I      intronic chr18:33595379(-) A-I      intronic chr18:33588427(-) A-I      intronic chr18:33584386(-) A-I      intronic chr18:33629003(-) A-I      intronic chr18:33576684(-) A-I      intronic chr18:33599831(-) A-I      intronic chr18:33610041(-) A-I      intronic chr18:33636523(-) A-I      intronic chr18:33599238(-) A-I      intronic chr18:33584391(-) A-I      intronic chr18:33597024(-) A-I      intronic chr18:33599891(-) A-I      intronic chr18:33601705(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RPRD1A	chr18:33575366(-) A-G intron -    22484847 chr18:33576879(-) A-G intron -    22484847 chr18:33583824(-) A-G intron -    22484847 chr18:33583900(-) A-G intron -    22484847 chr18:33584083(-) A-G intron -    22484847 chr18:33584346(-) A-G intron -    22484847 chr18:33584386(-) A-G intron -    22484847 chr18:33584741(-) A-G intron -    22484847 chr18:33584766(-) A-G intron -    22484847 chr18:33596441(-) A-G intron -    22484847 chr18:33599342(-) A-G intron -    22484847 chr18:33599343(-) A-G intron -    22484847 chr18:33602901(-) A-G intron -    22484847 chr18:33604391(-) A-G intron -    22484847 chr18:33604392(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RPRD1A	chr18:33564448-33564449(-) m6A 3'UTR       27773535 chr18:33572998-33572999(-) m6A 3'UTR//intron       24981863//22608085 chr18:33573013-33573014(-) m6A 3'UTR//intron       24981863//22608085 chr18:33573067-33573068(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573085-33573086(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573109-33573110(-) m6A 3'UTR       24284625//24981863//22608085 chr18:33573132-33573133(-) m6A CDS       24284625//24981863//22608085 chr18:33573189-33573190(-) m6A CDS       24284625//24981863//22575960//22608085 chr18:33573218-33573219(-) m6A CDS       24284625 chr18:33610779-33610780(-) m6A CDS       24981863 chr18:33610807-33610808(-) m6A CDS       24981863 chr18:33610833-33610834(-) m6A CDS       24981863 chr18:33610841-33610842(-) m6A CDS       24981863 chr18:33610963-33610964(-) m6A CDS       24981863 chr18:33610972-33610973(-) m6A CDS       24981863 chr18:33611055-33611056(-) m6A CDS       24981863 chr18:33613786-33613787(-) Y 3'UTR//CDS       26075521 chr18:33647262-33647263(-) m6A 5'UTR//CDS       27773536 chr18:33647294-33647295(-) m6A 5'UTR//CDS       27371828//27773536 chr18:33647333-33647334(-) m1A 5'UTR//CDS       26863196//26863410 chr18:33647421-33647422(-) m6A 5'UTR       24284625//24209618//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RPRD1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: RPRD1A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.