Basic Information:

  VIRBase ID:  

VHID00420335

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          BRWD1:  NM_001007246     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	BRWD1
miRBase Accession/Entrez ID	MIMAT0010132	54014
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C21orf107//DCAF19//N143//WDR9//WRD9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BRWD1	chr21:40589160(-) A-I      intronic chr21:40589159(-) A-I      intronic chr21:40589150(-) A-I      intronic chr21:40662315(-) A-I      intronic chr21:40680956(-) A-I      intronic chr21:40677122(-) A-I      intronic chr21:40675265(-) A-I      intronic chr21:40677104(-) A-I      intronic chr21:40677098(-) A-I      intronic chr21:40677059(-) A-I      intronic chr21:40667228(-) A-I      intronic chr21:40667218(-) A-I      intronic chr21:40667210(-) A-I      intronic chr21:40667178(-) A-I      intronic chr21:40612938(-) A-I      intronic chr21:40612923(-) A-I      intronic chr21:40612890(-) A-I      intronic chr21:40681358(-) A-I      intronic chr21:40681323(-) A-I      intronic chr21:40681302(-) A-I      intronic chr21:40589170(-) A-I      intronic chr21:40681301(-) A-I      intronic chr21:40680345(-) A-I      intronic chr21:40674742(-) A-I      intronic chr21:40674769(-) A-I      intronic chr21:40674820(-) A-I      intronic chr21:40675227(-) A-I      intronic chr21:40675328(-) A-I      intronic chr21:40675621(-) A-I      intronic chr21:40675630(-) A-I      intronic chr21:40675649(-) A-I      intronic chr21:40675654(-) A-I      intronic chr21:40675699(-) A-I      intronic chr21:40675717(-) A-I      intronic chr21:40675735(-) A-I      intronic chr21:40675842(-) A-I      intronic chr21:40676028(-) A-I      intronic chr21:40676997(-) A-I      intronic chr21:40677112(-) A-I      intronic chr21:40677135(-) A-I      intronic chr21:40677151(-) A-I      intronic chr21:40677157(-) A-I      intronic chr21:40677427(-) A-I      intronic chr21:40677532(-) A-I      intronic chr21:40579168(-) A-I      intronic chr21:40575471(-) A-I      intronic chr21:40575517(-) A-I      intronic chr21:40575538(-) A-I      intronic chr21:40575559(-) A-I      intronic chr21:40575562(-) A-I      intronic chr21:40575570(-) A-I      intronic chr21:40577402(-) A-I      intronic chr21:40579143(-) A-I      intronic chr21:40579164(-) A-I      intronic chr21:40579193(-) A-I      intronic chr21:40579213(-) A-I      intronic chr21:40580668(-) A-I      intronic chr21:40580674(-) A-I      intronic chr21:40580732(-) A-I      intronic chr21:40589118(-) A-I      intronic chr21:40612298(-) A-I      intronic chr21:40612368(-) A-I      intronic chr21:40613312(-) A-I      intronic chr21:40613385(-) A-I      intronic chr21:40615478(-) A-I      intronic chr21:40616012(-) A-I      intronic chr21:40616082(-) A-I      intronic chr21:40616086(-) A-I      intronic chr21:40616102(-) A-I      intronic chr21:40617634(-) A-I      intronic chr21:40617647(-) A-I      intronic chr21:40618752(-) A-I      intronic chr21:40631279(-) A-I      intronic chr21:40631290(-) A-I      intronic chr21:40635017(-) A-I      intronic chr21:40635025(-) A-I      intronic chr21:40641340(-) A-I      intronic chr21:40641350(-) A-I      intronic chr21:40644263(-) A-I      intronic chr21:40644396(-) A-I      intronic chr21:40644666(-) A-I      intronic chr21:40644682(-) A-I      intronic chr21:40644698(-) A-I      intronic chr21:40644716(-) A-I      intronic chr21:40661756(-) A-I      intronic chr21:40661761(-) A-I      intronic chr21:40663933(-) A-I      intronic chr21:40663965(-) A-I      intronic chr21:40666390(-) A-I      intronic chr21:40666394(-) A-I      intronic chr21:40666469(-) A-I      intronic chr21:40677546(-) A-I      intronic chr21:40677548(-) A-I      intronic chr21:40677565(-) A-I      intronic chr21:40677670(-) A-I      intronic chr21:40677707(-) A-I      intronic chr21:40678056(-) A-I      intronic chr21:40678063(-) A-I      intronic chr21:40678064(-) A-I      intronic chr21:40666497(-) A-I      intronic chr21:40678098(-) A-I      intronic chr21:40678156(-) A-I      intronic chr21:40678160(-) A-I      intronic chr21:40678224(-) A-I      intronic chr21:40678274(-) A-I      intronic chr21:40666535(-) A-I      intronic chr21:40667297(-) A-I      intronic chr21:40672983(-) A-I      intronic chr21:40672993(-) A-I      intronic chr21:40674007(-) A-I      intronic chr21:40674042(-) A-I      intronic chr21:40674074(-) A-I      intronic chr21:40674080(-) A-I      intronic chr21:40674083(-) A-I      intronic chr21:40674087(-) A-I      intronic chr21:40674088(-) A-I      intronic chr21:40674113(-) A-I      intronic chr21:40678891(-) A-I      intronic chr21:40678917(-) A-I      intronic chr21:40678928(-) A-I      intronic chr21:40678944(-) A-I      intronic chr21:40678950(-) A-I      intronic chr21:40678999(-) A-I      intronic chr21:40680164(-) A-I      intronic chr21:40680228(-) A-I      intronic chr21:40680284(-) A-I      intronic chr21:40680308(-) A-I      intronic chr21:40680322(-) A-I      intronic chr21:40680326(-) A-I      intronic chr21:40680332(-) A-I      intronic chr21:40680858(-) A-I      intronic chr21:40680917(-) A-I      intronic chr21:40680991(-) A-I      intronic chr21:40681038(-) A-I      intronic chr21:40682185(-) A-I      intronic chr21:40682197(-) A-I      intronic chr21:40682654(-) A-I      intronic chr21:40683165(-) A-I      intronic chr21:40674147(-) A-I      intronic chr21:40674478(-) A-I      intronic chr21:40674517(-) A-I      intronic chr21:40671909(-) A-I      intronic chr21:40631717(-) A-I      intronic chr21:40575605(-) A-I      intronic chr21:40601864(-) A-I      intronic chr21:40589182(-) A-I      intronic chr21:40671845(-) A-I      intronic chr21:40675201(-) A-I      intronic chr21:40663969(-) A-I      intronic chr21:40677127(-) A-I      intronic chr21:40672915(-) A-I      intronic chr21:40677144(-) A-I      intronic chr21:40677180(-) A-I      intronic chr21:40687473(-) A-I      intronic chr21:40671897(-) A-I      intronic chr21:40674047(-) A-I      intronic chr21:40617087(-) A-I      intronic chr21:40658149(-) A-I      intronic chr21:40677577(-) A-I      intronic chr21:40677677(-) A-I      intronic chr21:40680151(-) A-I      intronic chr21:40644671(-) A-I      intronic chr21:40676410(-) A-I      intronic chr21:40674874(-) A-I      intronic chr21:40663907(-) A-I      intronic chr21:40617729(-) A-I      intronic chr21:40644331(-) A-I      intronic chr21:40639517(-) A-I      intronic chr21:40617622(-) A-I      intronic chr21:40677556(-) A-I      intronic chr21:40671809(-) A-I      intronic chr21:40631355(-) A-I      intronic chr21:40664143(-) A-I      intronic chr21:40615447(-) A-I      intronic chr21:40658674(-) A-I      intronic chr21:40677450(-) A-I      intronic chr21:40677088(-) A-I      intronic chr21:40687477(-) A-I      intronic chr21:40678179(-) A-I      intronic chr21:40687478(-) A-I      intronic chr21:40675876(-) A-I      intronic chr21:40600137(-) A-I      intronic chr21:40575514(-) A-I      intronic chr21:40579176(-) A-I      intronic chr21:40631250(-) A-I      intronic chr21:40677449(-) A-I      intronic chr21:40664154(-) A-I      intronic chr21:40674729(-) A-I      intronic chr21:40683162(-) A-I      intronic chr21:40580746(-) A-I      intronic chr21:40586846(-) A-I      intronic chr21:40680163(-) A-I      intronic chr21:40676964(-) A-I      intronic chr21:40678093(-) A-I      intronic chr21:40674667(-) A-I      intronic chr21:40677864(-) A-I      intronic chr21:40677547(-) A-I      intronic chr21:40617167(-) A-I      intronic chr21:40677851(-) A-I      intronic chr21:40579341(-) A-I      intronic chr21:40678229(-) A-I      intronic chr21:40680242(-) A-I      intronic chr21:40683124(-) A-I      intronic chr21:40617739(-) A-I      intronic chr21:40683258(-) A-I      intronic chr21:40677463(-) A-I      intronic chr21:40677079(-) A-I      intronic chr21:40682360(-) A-I      intronic chr21:40613272(-) A-I      intronic chr21:40639523(-) A-I      intronic chr21:40676478(-) A-I      intronic chr21:40680978(-) A-I      intronic chr21:40667179(-) A-I      intronic chr21:40612915(-) A-I      intronic chr21:40664006(-) A-I      intronic chr21:40674021(-) A-I      intronic chr21:40615492(-) A-I      intronic chr21:40680296(-) A-I      intronic chr21:40591235(-) A-I      intronic chr21:40666340(-) A-I      intronic chr21:40677708(-) A-I      intronic chr21:40674922(-) A-I      intronic chr21:40644742(-) A-I      intronic chr21:40613331(-) A-I      intronic chr21:40666567(-) A-I      intronic chr21:40644672(-) A-I      intronic chr21:40579308(-) A-I      intronic chr21:40680934(-) A-I      intronic chr21:40607040(-) A-I      intronic chr21:40671787(-) A-I      intronic chr21:40617629(-) A-I      intronic chr21:40612916(-) A-I      intronic chr21:40674899(-) A-I      intronic chr21:40612964(-) A-I      intronic chr21:40677050(-) A-I      intronic chr21:40591181(-) A-I      intronic chr21:40680976(-) A-I      intronic chr21:40657638(-) A-I      intronic chr21:40680362(-) A-I      intronic chr21:40674741(-) A-I      intronic chr21:40644741(-) A-I      intronic chr21:40626181(-) A-I      intronic chr21:40662883(-) A-I      intronic chr21:40575503(-) A-I      intronic chr21:40631641(-) A-I      intronic chr21:40580698(-) A-I      intronic chr21:40613237(-) A-I      intronic chr21:40671683(-) A-I      intronic chr21:40575234(-) A-I      intronic chr21:40641293(-) A-I      intronic chr21:40674743(-) A-I      intronic chr21:40667182(-) A-I      intronic chr21:40631663(-) A-I      intronic chr21:40595912(-) A-I      intronic chr21:40575507(-) A-I      intronic chr21:40644588(-) A-I      intronic chr21:40658150(-) A-I      intronic chr21:40615534(-) A-I      intronic chr21:40680033(-) A-I      intronic chr21:40681000(-) A-I      intronic chr21:40676526(-) A-I      intronic chr21:40677641(-) A-I      intronic chr21:40617176(-) A-I      intronic chr21:40674823(-) A-I      intronic chr21:40677645(-) A-I      intronic chr21:40675687(-) A-I      intronic chr21:40683261(-) A-I      intronic chr21:40678290(-) A-I      intronic chr21:40644606(-) A-I      intronic chr21:40673938(-) A-I      intronic chr21:40683370(-) A-I      intronic chr21:40589133(-) A-I      intronic chr21:40680245(-) A-I      intronic chr21:40615627(-) A-I      intronic chr21:40580696(-) A-I      intronic chr21:40601841(-) A-I      intronic chr21:40677623(-) A-I      intronic chr21:40658147(-) A-I      intronic chr21:40612401(-) A-I      intronic chr21:40649550(-) A-I      intronic chr21:40677034(-) A-I      intronic chr21:40677068(-) A-I      intronic chr21:40657664(-) A-I      intronic chr21:40612373(-) A-I      intronic chr21:40682758(-) A-I      intronic chr21:40612357(-) A-I      intronic chr21:40674794(-) A-I      intronic chr21:40674182(-) A-I      intronic chr21:40615650(-) A-I      intronic chr21:40677092(-) A-I      intronic chr21:40671867(-) A-I      intronic chr21:40675833(-) A-I      intronic chr21:40671644(-) A-I      intronic chr21:40677014(-) A-I      intronic chr21:40641360(-) A-I      intronic chr21:40681629(-) A-I      intronic chr21:40591184(-) A-I      intronic chr21:40613282(-) A-I      intronic chr21:40675967(-) A-I      intronic chr21:40615510(-) A-I      intronic chr21:40593073(-) A-I      intronic chr21:40681315(-) A-I      intronic chr21:40674048(-) A-I      intronic chr21:40658696(-) A-I      intronic chr21:40676354(-) A-I      intronic chr21:40675276(-) A-I      intronic chr21:40674012(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BRWD1	chr21:40580659(-) A-I intron -    21960545 chr21:40580696(-) A-I intron -    21960545 chr21:40617087(-) A-I intron -    21960545 chr21:40641360(-) A-I intron -    21960545 chr21:40662837(-) A-I intron -    21960545 chr21:40663005(-) A-I intron -    21960545 chr21:40664143(-) A-I intron -    21960545 chr21:40671909(-) A-I intron -    21960545 chr21:40676526(-) A-I intron -    21960545 chr21:40681365(-) A-I intron -    21960545 chr21:40683340(-) A-I intron -    21960545 chr21:40683353(-) A-I intron -    21960545 chr21:40683370(-) A-I intron -    21960545 chr21:40658147(-) A-G intron -    22484847 chr21:40671832(-) A-G intron -    22484847 chr21:40671846(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BRWD1	chr21:40556817-40556818(-) m6A 3'UTR       27773535 chr21:40556832-40556833(-) m6A 3'UTR       27773535 chr21:40556838-40556839(-) m6A 3'UTR       27773535 chr21:40556892-40556893(-) m6A 3'UTR       27773535 chr21:40557969-40557970(-) m6A 3'UTR       27773535 chr21:40557994-40557995(-) m6A 3'UTR       27773535 chr21:40558013-40558014(-) m6A 3'UTR       27773535 chr21:40558076-40558077(-) m6A 3'UTR       27773535 chr21:40558382-40558383(-) m6A 3'UTR       27773535 chr21:40558395-40558396(-) m6A 3'UTR       27773535 chr21:40558441-40558442(-) m6A 3'UTR       27773535 chr21:40558661-40558662(-) m6A 3'UTR       27773535 chr21:40558696-40558697(-) m6A 3'UTR       27773535 chr21:40558715-40558716(-) m6A 3'UTR       27773535 chr21:40558786-40558787(-) m6A 3'UTR       27773535 chr21:40558890-40558891(-) Y 3'UTR       26075521 chr21:40559116-40559117(-) m6A CDS       24981863//27773535 chr21:40559152-40559153(-) m6A CDS       24981863//27773535 chr21:40559256-40559257(-) m6A 3'UTR//CDS       27773535 chr21:40559301-40559302(-) m6A 3'UTR//CDS       27773535 chr21:40564211-40564212(-) m6A 3'UTR//intron       27773535 chr21:40564253-40564254(-) m6A 3'UTR//intron       27773535 chr21:40564285-40564286(-) m6A 3'UTR//intron       27773535 chr21:40564334-40564335(-) m6A 3'UTR//intron       27773535 chr21:40564366-40564367(-) m6A 3'UTR//intron       27773535 chr21:40568147-40568148(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr21:40568258-40568259(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr21:40568323-40568324(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr21:40568376-40568377(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr21:40568393-40568394(-) m6A CDS//intron       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr21:40568417-40568418(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr21:40568468-40568469(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr21:40568544-40568545(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40568567-40568568(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960//22608085 chr21:40568633-40568634(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40568660-40568661(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr21:40568687-40568688(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr21:40568694-40568695(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr21:40568730-40568731(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr21:40568792-40568793(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr21:40568801-40568802(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40568913-40568914(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40568938-40568939(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40568944-40568945(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40569024-40569025(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//22575960//22608085 chr21:40569105-40569106(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr21:40569230-40569231(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40569271-40569272(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40569318-40569319(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40569325-40569326(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40570702-40570703(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40570707-40570708(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40570742-40570743(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40570792-40570793(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40570813-40570814(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40570843-40570844(-) Am 3'UTR//CDS       - chr21:40570870-40570871(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr21:40570895-40570896(-) m6A 3'UTR//CDS       24284625//24981863//27773535//27371828//22575960//22608085 chr21:40570959-40570960(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr21:40570998-40570999(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr21:40571027-40571028(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr21:40571065-40571066(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40571099-40571100(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22575960//22608085 chr21:40571185-40571186(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr21:40571191-40571192(-) m6A 3'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr21:40571298-40571299(-) m6A 3'UTR//CDS       22608085 chr21:40571501-40571502(-) m6A 3'UTR//CDS//exon       24981863 chr21:40622741-40622742(-) m6A 3'UTR//CDS       24981863 chr21:40630503-40630504(-) m6A 3'UTR//CDS       24284625 chr21:40630559-40630560(-) m6A 3'UTR//CDS       24284625 chr21:40630578-40630579(-) m6A 3'UTR//CDS       24284625 chr21:40646344-40646345(-) Tm CDS       - chr21:40646372-40646373(-) m6A CDS       27773535 chr21:40669008-40669009(-) Y 3'UTR//intron       26075521 chr21:40670208-40670209(-) m6A 3'UTR//exon//intron       24981863 chr21:40670237-40670238(-) m6A 3'UTR//exon//intron       24981863 chr21:40686507-40686508(-) m6A intron       - chr21:40686536-40686537(-) m6A intron       - chr21:40686601-40686602(-) m6A intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BRWD1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: BRWD1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.