Basic Information:

  VIRBase ID:  

VHID00420066

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          ZBTB44:  NR_163264     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	ZBTB44
miRBase Accession/Entrez ID	MIMAT0010132	29068
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BTBD15//HSPC063//ZNF851

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB44	chr11:130132899(-) A-I      intronic chr11:130179758(-) A-I      intronic chr11:130177076(-) A-I      intronic chr11:130181218(-) A-I      intronic chr11:130155433(-) A-I      intronic chr11:130161119(-) A-I      intronic chr11:130161142(-) A-I      intronic chr11:130161237(-) A-I      intronic chr11:130168154(-) A-I      intronic chr11:130168234(-) A-I      intronic chr11:130168240(-) A-I      intronic chr11:130168972(-) A-I      intronic chr11:130171292(-) A-I      intronic chr11:130171451(-) A-I      intronic chr11:130172634(-) A-I      intronic chr11:130172758(-) A-I      intronic chr11:130173430(-) A-I      intronic chr11:130168193(-) A-I      intronic chr11:130173454(-) A-I      intronic chr11:130177196(-) A-I      intronic chr11:130177589(-) A-I      intronic chr11:130177595(-) A-I      intronic chr11:130177780(-) A-I      intronic chr11:130177814(-) A-I      intronic chr11:130177816(-) A-I      intronic chr11:130177820(-) A-I      intronic chr11:130177853(-) A-I      intronic chr11:130179675(-) A-I      intronic chr11:130179678(-) A-I      intronic chr11:130179757(-) A-I      intronic chr11:130180760(-) A-I      intronic chr11:130180770(-) A-I      intronic chr11:130181322(-) A-I      intronic chr11:130141940(-) A-I      intronic chr11:130153917(-) A-I      intronic chr11:130179753(-) A-I      intronic chr11:130132103(-) A-I      intronic chr11:130145651(-) A-I      intronic chr11:130132131(-) A-I      intronic chr11:130145605(-) A-I      intronic chr11:130168313(-) A-I      intronic chr11:130145788(-) A-I      intronic chr11:130180007(-) A-I      intronic chr11:130132942(-) A-I      intronic chr11:130181323(-) A-I      intronic chr11:130146397(-) A-I      intronic chr11:130168158(-) A-I      intronic chr11:130145341(-) A-I      intronic chr11:130179704(-) A-I      intronic chr11:130168964(-) A-I      intronic chr11:130143974(-) A-I      intronic chr11:130139072(-) A-I      intronic chr11:130146523(-) A-I      intronic chr11:130137096(-) A-I      intronic chr11:130143921(-) A-I      intronic chr11:130161304(-) A-I      intronic chr11:130146525(-) A-I      intronic chr11:130105859(-) A-I      intronic chr11:130110002(-) A-I      intronic chr11:130114369(-) A-I      intronic chr11:130114373(-) A-I      intronic chr11:130132120(-) A-I      intronic chr11:130132172(-) A-I      intronic chr11:130132238(-) A-I      intronic chr11:130132306(-) A-I      intronic chr11:130132307(-) A-I      intronic chr11:130132313(-) A-I      intronic chr11:130132856(-) A-I      intronic chr11:130137416(-) A-I      intronic chr11:130139062(-) A-I      intronic chr11:130139115(-) A-I      intronic chr11:130141869(-) A-I      intronic chr11:130141882(-) A-I      intronic chr11:130141900(-) A-I      intronic chr11:130142040(-) A-I      intronic chr11:130143372(-) A-I      intronic chr11:130143375(-) A-I      intronic chr11:130143401(-) A-I      intronic chr11:130143402(-) A-I      intronic chr11:130143426(-) A-I      intronic chr11:130143497(-) A-I      intronic chr11:130143691(-) A-I      intronic chr11:130143698(-) A-I      intronic chr11:130143839(-) A-I      intronic chr11:130143874(-) A-I      intronic chr11:130143920(-) A-I      intronic chr11:130143440(-) A-I      intronic chr11:130145690(-) A-I      intronic chr11:130145749(-) A-I      intronic chr11:130145896(-) A-I      intronic chr11:130145941(-) A-I      intronic chr11:130146087(-) A-I      intronic chr11:130146398(-) A-I      intronic chr11:130146406(-) A-I      intronic chr11:130146422(-) A-I      intronic chr11:130146440(-) A-I      intronic chr11:130146444(-) A-I      intronic chr11:130146591(-) A-I      intronic chr11:130146596(-) A-I      intronic chr11:130146613(-) A-I      intronic chr11:130151235(-) A-I      intronic chr11:130151270(-) A-I      intronic chr11:130151628(-) A-I      intronic chr11:130151685(-) A-I      intronic chr11:130151729(-) A-I      intronic chr11:130152821(-) A-I      intronic chr11:130152846(-) A-I      intronic chr11:130153924(-) A-I      intronic chr11:130154519(-) A-I      intronic chr11:130154529(-) A-I      intronic chr11:130177208(-) A-I      intronic chr11:130154599(-) A-I      intronic chr11:130154614(-) A-I      intronic chr11:130154654(-) A-I      intronic chr11:130154761(-) A-I      intronic chr11:130155289(-) A-I      intronic chr11:130155311(-) A-I      intronic chr11:130155324(-) A-I      intronic chr11:130143859(-) A-I      intronic chr11:130155365(-) A-I      intronic chr11:130155375(-) A-I      intronic chr11:130177759(-) A-I      intronic chr11:130155380(-) A-I      intronic chr11:130155381(-) A-I      intronic chr11:130155414(-) A-I      intronic chr11:130109719(-) A-I      NonSyn:Asp->Gly chr11:130132064(-) A-I      intronic chr11:130168238(-) A-I      intronic chr11:130143329(-) A-I      intronic chr11:130168237(-) A-I      intronic chr11:130179960(-) A-I      intronic chr11:130179705(-) A-I      intronic chr11:130143871(-) A-I      intronic chr11:130168866(-) A-I      intronic chr11:130168291(-) A-I      intronic chr11:130168081(-) A-I      intronic chr11:130181360(-) A-I      intronic chr11:130132861(-) A-I      intronic chr11:130139101(-) A-I      intronic chr11:130143883(-) A-I      intronic chr11:130155275(-) A-I      intronic chr11:130164141(-) A-I      intronic chr11:130151661(-) A-I      intronic chr11:130152832(-) A-I      intronic chr11:130168295(-) A-I      intronic chr11:130177785(-) A-I      intronic chr11:130151266(-) A-I      intronic chr11:130145933(-) A-I      intronic chr11:130168290(-) A-I      intronic chr11:130141875(-) A-I      intronic chr11:130168076(-) A-I      intronic chr11:130177138(-) A-I      intronic chr11:130143281(-) A-I      intronic chr11:130155315(-) A-I      intronic chr11:130151587(-) A-I      intronic chr11:130151586(-) A-I      intronic chr11:130177090(-) A-I      intronic chr11:130139068(-) A-I      intronic chr11:130180752(-) A-I      intronic chr11:130145793(-) A-I      intronic chr11:130138612(-) A-I      intronic chr11:130177211(-) A-I      intronic chr11:130145369(-) A-I      intronic chr11:130168869(-) A-I      intronic chr11:130137059(-) A-I      intronic chr11:130177063(-) A-I      intronic chr11:130181398(-) A-I      intronic chr11:130151601(-) A-I      intronic chr11:130143333(-) A-I      intronic chr11:130153949(-) A-I      intronic chr11:130153967(-) A-I      intronic chr11:130168153(-) A-I      intronic chr11:130145360(-) A-I      intronic chr11:130168162(-) A-I      intronic chr11:130137511(-) A-I      intronic chr11:130177276(-) A-I      intronic chr11:130143861(-) A-I      intronic chr11:130132880(-) A-I      intronic chr11:130151718(-) A-I      intronic chr11:130146512(-) A-I      intronic chr11:130145771(-) A-I      intronic chr11:130137123(-) A-I      intronic chr11:130137353(-) A-I      intronic chr11:130145687(-) A-I      intronic chr11:130141933(-) A-I      intronic chr11:130161305(-) A-I      intronic chr11:130151894(-) A-I      intronic chr11:130146458(-) A-I      intronic chr11:130181347(-) A-I      intronic chr11:130132834(-) A-I      intronic chr11:130145924(-) A-I      intronic chr11:130126498(-) A-I      intronic chr11:130177614(-) A-I      intronic chr11:130171691(-) A-I      intronic chr11:130153077(-) A-I      intronic chr11:130177825(-) A-I      intronic chr11:130145865(-) A-I      intronic chr11:130144062(-) A-I      intronic chr11:130180008(-) A-I      intronic chr11:130137393(-) A-I      intronic chr11:130137903(-) A-I      intronic chr11:130177198(-) A-I      intronic chr11:130141945(-) A-I      intronic chr11:130151734(-) A-I      intronic chr11:130137417(-) A-I      intronic chr11:130177075(-) A-I      intronic chr11:130145591(-) A-I      intronic chr11:130132227(-) A-I      intronic chr11:130132237(-) A-I      intronic chr11:130154678(-) A-I      intronic chr11:130154661(-) A-I      intronic chr11:130146526(-) A-I      intronic chr11:130154507(-) A-I      intronic chr11:130142091(-) A-I      intronic chr11:130154709(-) A-I      intronic chr11:130137379(-) A-I      intronic chr11:130137574(-) A-I      intronic chr11:130146197(-) A-I      intronic chr11:130168585(-) A-I      intronic chr11:130137589(-) A-I      intronic chr11:130138628(-) A-I      intronic chr11:130137580(-) A-I      intronic chr11:130151258(-) A-I      intronic chr11:130138605(-) A-I      intronic chr11:130180041(-) A-I      intronic chr11:130152994(-) A-I      intronic chr11:130177749(-) A-I      intronic chr11:130145794(-) A-I      intronic chr11:130168312(-) A-I      intronic chr11:130146470(-) A-I      intronic chr11:130177130(-) A-I      intronic chr11:130137159(-) A-I      intronic chr11:130146069(-) A-I      intronic chr11:130166011(-) A-I      intronic chr11:130145739(-) A-I      intronic chr11:130146074(-) A-I      intronic chr11:130168812(-) A-I      intronic chr11:130143343(-) A-I      intronic chr11:130143899(-) A-I      intronic chr11:130154596(-) A-I      intronic chr11:130168956(-) A-I      intronic chr11:130154649(-) A-I      intronic chr11:130153926(-) A-I      intronic chr11:130137082(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZBTB44	chr11:130109719(-) A-I exon CDS    19478186 chr11:130165965(-) A-I intron -    22327324 chr11:130166011(-) A-I intron -    22327324 chr11:130144062(-) A-G intron -    22484847 chr11:130146197(-) A-G intron -    22484847 chr11:130137082(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB44	chr11:130101708-130101709(-) m6A 3'UTR//intron       27773535 chr11:130103176-130103177(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr11:130103628-130103629(-) m6A 3'UTR//intron       27773535 chr11:130103643-130103644(-) m6A 3'UTR//intron       27773535 chr11:130103654-130103655(-) m6A 3'UTR//intron       27773535 chr11:130103662-130103663(-) m6A 3'UTR//intron       27773535 chr11:130103668-130103669(-) m6A 3'UTR//intron       27773535 chr11:130104098-130104099(-) m6A 3'UTR//CDS//intron       24284625//24981863//22608085 chr11:130104124-130104125(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104134-130104135(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104141-130104142(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130104150-130104151(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//22608085 chr11:130106022-130106023(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr11:130106053-130106054(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr11:130106642-130106643(-) m6A exon//intron       24981863 chr11:130106654-130106655(-) m6A exon//intron       24981863 chr11:130106668-130106669(-) m6A exon//intron       24284625//24981863//22608085 chr11:130106702-130106703(-) m6A CDS//exon//intron       24284625//24981863//22608085 chr11:130106726-130106727(-) m6A CDS//exon//intron       24284625//24981863//22608085 chr11:130106784-130106785(-) m6A CDS//exon//intron       24981863//22608085 chr11:130106842-130106843(-) m6A CDS//exon//intron       22608085 chr11:130130782-130130783(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130796-130130797(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130813-130130814(-) m6A 3'UTR//CDS//exon       27773535//22608085 chr11:130130939-130130940(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130130984-130130985(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131011-130131012(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131077-130131078(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:130131112-130131113(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr11:130131164-130131165(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr11:130131251-130131252(-) m6A CDS//exon       24284625//24209618//24981863//27371828//22608085 chr11:130131336-130131337(-) m6A CDS//exon       24284625//24981863//26404942//22608085 chr11:130131565-130131566(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr11:130131591-130131592(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:130131652-130131653(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:130131684-130131685(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:130131755-130131756(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//22608085 chr11:130131822-130131823(-) m6A 5'UTR//exon       24284625//24209618//24981863//27371828//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZBTB44	Chromatin K562 cells     - Cytoplasm Cell line (HeLa)     22319583 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Cell line (HeLa)     22319583 Nucleus HeLa-S3 cells|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: ZBTB44

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.