Detail Information

Basic Information:


  VIRBase ID:  

VHID00419742

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:           KIAA0895:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART22 KIAA0895
miRBase
Accession/Entrez ID		 MIMAT0010132 23366
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KIAA0895
chr7:36405225(-) A-I      intronic
chr7:36375488(-) A-I      intronic
chr7:36403915(-) A-I      intronic
chr7:36375475(-) A-I      intronic
chr7:36403825(-) A-I      intronic
chr7:36375463(-) A-I      intronic
chr7:36392621(-) A-I      intronic
chr7:36405221(-) A-I      intronic
chr7:36397685(-) A-I      intronic
chr7:36392666(-) A-I      intronic
chr7:36390883(-) A-I      intronic
chr7:36390232(-) A-I      intronic
chr7:36392826(-) A-I      intronic
chr7:36401282(-) A-I      intronic
chr7:36401279(-) A-I      intronic
chr7:36369797(-) A-I      intronic
chr7:36403954(-) A-I      intronic
chr7:36367829(-) A-I      intronic
chr7:36405232(-) A-I      intronic
chr7:36367794(-) A-I      intronic
chr7:36390327(-) A-I      intronic
chr7:36403835(-) A-I      intronic
chr7:36377985(-) A-I      intronic
chr7:36375435(-) A-I      intronic
chr7:36403977(-) A-I      intronic
chr7:36368269(-) A-I      intronic
chr7:36379771(-) A-I      intronic
chr7:36392836(-) A-I      intronic
chr7:36405046(-) A-I      intronic
chr7:36390289(-) A-I      intronic
chr7:36405197(-) A-I      intronic
chr7:36367756(-) A-I      intronic
chr7:36378031(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KIAA0895
chr7:36366853(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KIAA0895
chr7:36365540-36365541(-) m6A 3'UTR       26404942
chr7:36365563-36365564(-) m6A 3'UTR       26404942
chr7:36366204-36366205(-) m6A 3'UTR       27773535//22608085
chr7:36366273-36366274(-) m6A 3'UTR       24284625//27773535//22608085
chr7:36366349-36366350(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr7:36366386-36366387(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr7:36366401-36366402(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr7:36366431-36366432(-) m6A CDS       24284625//24981863//27773535//22608085
chr7:36366450-36366451(-) m6A CDS       24284625//24981863//27773535//22608085
chr7:36366477-36366478(-) m6A CDS       24284625//24981863//27773535//22608085
chr7:36370618-36370619(-) m6A CDS       24284625//27773535//22608085
chr7:36370672-36370673(-) m6A CDS       24284625//27773535//22608085
chr7:36373482-36373483(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr7:36373529-36373530(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr7:36373561-36373562(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085
chr7:36373631-36373632(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085
chr7:36373666-36373667(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr7:36373702-36373703(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr7:36373716-36373717(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr7:36373724-36373725(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr7:36374764-36374765(-) m6A CDS//exon       27773535
chr7:36375818-36375819(-) m6A CDS//exon//intron       27773535
chr7:36375849-36375850(-) m6A CDS//exon//intron       27773535
chr7:36375888-36375889(-) m6A CDS//exon//intron       27773535
chr7:36396430-36396431(-) m6A CDS//exon//intron       27773535//22608085
chr7:36396436-36396437(-) m6A CDS//exon//intron       27773535//22608085
chr7:36396464-36396465(-) m6A CDS//exon//intron       27773535//22608085
chr7:36396624-36396625(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:36396648-36396649(-) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:36396774-36396775(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr7:36396969-36396970(-) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085
chr7:36397005-36397006(-) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22608085
chr7:36397064-36397065(-) m6A 5'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//22608085
chr7:36397081-36397082(-) m6A 5'UTR//CDS//exon//intron       24209618//24981863//27773535//22608085
chr7:36397173-36397174(-) m6A 5'UTR//CDS//exon//intron       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate KIAA0895
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART22
Interactor2: KIAA0895

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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