Basic Information:

  VIRBase ID:  

VHID00419542

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          CILK1:  NR_164684     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	CILK1
miRBase Accession/Entrez ID	MIMAT0010132	22858
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ECO//EJM10//hICK//ICK//LCK2//MRK

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CILK1	chr6:52892577(-) A-I      intronic chr6:52914791(-) A-I      intronic chr6:52892573(-) A-I      intronic chr6:52886001(-) A-I      intronic chr6:52914785(-) A-I      intronic chr6:52892611(-) A-I      intronic chr6:52892585(-) A-I      intronic chr6:52886041(-) A-I      intronic chr6:52886037(-) A-I      intronic chr6:52886036(-) A-I      intronic chr6:52886028(-) A-I      intronic chr6:52872694(-) A-I      intronic chr6:52914731(-) A-I      intronic chr6:52868290(-) A-I      3'UTR chr6:52868293(-) A-I      3'UTR chr6:52868316(-) A-I      3'UTR chr6:52868348(-) A-I      3'UTR chr6:52868294(-) A-I      3'UTR chr6:52873399(-) A-I      intronic chr6:52873502(-) A-I      intronic chr6:52889898(-) A-I      intronic chr6:52868457(-) A-I      3'UTR chr6:52896881(-) A-I      intronic chr6:52873361(-) A-I      intronic chr6:52873406(-) A-I      intronic chr6:52873470(-) A-I      intronic chr6:52914792(-) A-I      intronic chr6:52872655(-) A-I      intronic chr6:52887860(-) A-I      intronic chr6:52885862(-) A-I      intronic chr6:52893038(-) A-I      intronic chr6:52873525(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CILK1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: CILK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.