Basic Information:

  VIRBase ID:  

VHID00419490

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          WDR6:  NM_018031     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	WDR6
miRBase Accession/Entrez ID	MIMAT0010132	11180
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WDR6	chr3:49050922(+) A-I      NonSyn:Asn->Ser chr3:49047988(+) A-I      intronic chr3:49047965(+) A-I      intronic chr3:49047438(+) A-I      intronic chr3:49047383(+) A-I      intronic chr3:49046544(+) A-I      intronic chr3:49046489(+) A-I      intronic chr3:49046481(+) A-I      intronic chr3:49046480(+) A-I      intronic chr3:49046456(+) A-I      intronic chr3:49047381(+) A-I      intronic chr3:49046607(+) A-I      intronic chr3:49046605(+) A-I      intronic chr3:49046395(+) A-I      intronic chr3:49047877(+) A-I      intronic chr3:49047875(+) A-I      intronic chr3:49046586(+) A-I      intronic chr3:49048659(+) A-I      intronic chr3:49048457(+) A-I      intronic chr3:49047767(+) A-I      intronic chr3:49047759(+) A-I      intronic chr3:49047682(+) A-I      intronic chr3:49047679(+) A-I      intronic chr3:49047676(+) A-I      intronic chr3:49047662(+) A-I      intronic chr3:49047661(+) A-I      intronic chr3:49047656(+) A-I      intronic chr3:49047652(+) A-I      intronic chr3:49048431(+) A-I      intronic chr3:49048356(+) A-I      intronic chr3:49048346(+) A-I      intronic chr3:49048265(+) A-I      intronic chr3:49048263(+) A-I      intronic chr3:49048168(+) A-I      intronic chr3:49048152(+) A-I      intronic chr3:49048034(+) A-I      intronic chr3:49046370(+) A-I      intronic chr3:49046338(+) A-I      intronic chr3:49048746(+) A-I      intronic chr3:49046451(+) A-I      intronic chr3:49047651(+) A-I      intronic chr3:49047628(+) A-I      intronic chr3:49047415(+) A-I      intronic chr3:49047224(+) A-I      intronic chr3:49047971(+) A-I      intronic chr3:49047953(+) A-I      intronic chr3:49047915(+) A-I      intronic chr3:49047893(+) A-I      intronic chr3:49046515(+) A-I      intronic chr3:49046567(+) A-I      intronic chr3:49047771(+) A-I      intronic chr3:49047972(+) A-I      intronic chr3:49047225(+) A-I      intronic chr3:49047878(+) A-I      intronic chr3:49048028(+) A-I      intronic chr3:49046535(+) A-I      intronic chr3:49047322(+) A-I      intronic chr3:49048786(+) A-I      intronic chr3:49047692(+) A-I      intronic chr3:49048045(+) A-I      intronic chr3:49047973(+) A-I      intronic chr3:49046591(+) A-I      intronic chr3:49048774(+) A-I      intronic chr3:49048663(+) A-I      intronic chr3:49046589(+) A-I      intronic chr3:49048370(+) A-I      intronic chr3:49047197(+) A-I      intronic chr3:49047416(+) A-I      intronic chr3:49048303(+) A-I      intronic chr3:49048780(+) A-I      intronic chr3:49047718(+) A-I      intronic chr3:49047788(+) A-I      intronic chr3:49048136(+) A-I      intronic chr3:49047829(+) A-I      intronic chr3:49047302(+) A-I      intronic chr3:49046454(+) A-I      intronic chr3:49048647(+) A-I      intronic chr3:49048162(+) A-I      intronic chr3:49046512(+) A-I      intronic chr3:49048329(+) A-I      intronic chr3:49048371(+) A-I      intronic chr3:49047962(+) A-I      intronic chr3:49047963(+) A-I      intronic chr3:49047758(+) A-I      intronic chr3:49048378(+) A-I      intronic chr3:49047990(+) A-I      intronic chr3:49046498(+) A-I      intronic chr3:49048067(+) A-I      intronic chr3:49047789(+) A-I      intronic chr3:49046595(+) A-I      intronic chr3:49048726(+) A-I      intronic chr3:49048204(+) A-I      intronic chr3:49047724(+) A-I      intronic chr3:49047300(+) A-I      intronic chr3:49048172(+) A-I      intronic chr3:49047417(+) A-I      intronic chr3:49046408(+) A-I      intronic chr3:49048096(+) A-I      intronic chr3:49046576(+) A-I      intronic chr3:49048361(+) A-I      intronic chr3:49046476(+) A-I      intronic chr3:49047278(+) A-I      intronic chr3:49048339(+) A-I      intronic chr3:49047916(+) A-I      intronic chr3:49046577(+) A-I      intronic chr3:49048075(+) A-I      intronic chr3:49048029(+) A-I      intronic chr3:49048694(+) A-I      intronic chr3:49048773(+) A-I      intronic chr3:49047590(+) A-I      intronic chr3:49046415(+) A-I      intronic chr3:49048211(+) A-I      intronic chr3:49047987(+) A-I      intronic chr3:49046354(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	WDR6	chr3:49046454(+) A-I intron -    22327324 chr3:49046515(+) A-I intron -    22327324 chr3:49047718(+) A-I intron -    22327324 chr3:49047728(+) A-I intron -    22327324 chr3:49047771(+) A-I intron -    22327324 chr3:49047788(+) A-I intron -    22327324 chr3:49047963(+) A-I intron -    22327324 chr3:49048657(+) A-I intron -    22327324 chr3:49048726(+) A-I intron -    22327324 chr3:49048780(+) A-I intron -    21960545   //22327324 chr3:49048370(+) A-I intron -    21960545 chr3:49048371(+) A-I intron -    21960545 chr3:49048786(+) A-I intron -    21960545 chr3:49046336(+) A-I intron -    21960545 chr3:49046353(+) C-T intron -    22484847 chr3:49046354(+) A-G intron -    22484847 chr3:49046376(+) A-G intron -    22484847 chr3:49046408(+) A-G intron -    22484847 chr3:49046415(+) A-G intron -    22484847 chr3:49046432(+) A-G intron -    22484847 chr3:49046444(+) A-G intron -    22484847 chr3:49046454(+) A-G intron -    22484847 chr3:49046464(+) A-G intron -    22484847 chr3:49046476(+) A-G intron -    22484847 chr3:49046495(+) A-G intron -    22484847 chr3:49046512(+) A-G intron -    22484847 chr3:49046515(+) A-G intron -    22484847 chr3:49046524(+) A-G intron -    22484847 chr3:49046535(+) A-G intron -    22484847 chr3:49046567(+) A-G intron -    22484847 chr3:49046576(+) A-G intron -    22484847 chr3:49046577(+) A-G intron -    22484847 chr3:49047230(+) A-G intron -    22484847 chr3:49047290(+) A-G intron -    22484847 chr3:49047417(+) A-G intron -    22484847 chr3:49047718(+) A-G intron -    22484847 chr3:49047724(+) A-G intron -    22484847 chr3:49047771(+) A-G intron -    22484847 chr3:49047788(+) A-G intron -    22484847 chr3:49047789(+) A-G intron -    22484847 chr3:49047939(+) A-G intron -    22484847 chr3:49047962(+) A-G intron -    22484847 chr3:49047963(+) A-G intron -    22484847 chr3:49047984(+) A-G intron -    22484847 chr3:49048026(+) A-G intron -    22484847 chr3:49048028(+) A-G intron -    22484847 chr3:49048029(+) A-G intron -    22484847 chr3:49048072(+) A-G intron -    22484847 chr3:49048136(+) A-G intron -    22484847 chr3:49048162(+) A-G intron -    22484847 chr3:49048172(+) A-G intron -    22484847 chr3:49048271(+) A-G intron -    22484847 chr3:49048330(+) A-G intron -    22484847 chr3:49048339(+) A-G intron -    22484847 chr3:49048371(+) A-G intron -    22484847 chr3:49048617(+) A-G intron -    22484847 chr3:49048618(+) A-G intron -    22484847 chr3:49048635(+) A-G intron -    22484847 chr3:49048647(+) A-G intron -    22484847 chr3:49048657(+) A-G intron -    22484847 chr3:49048663(+) A-G intron -    22484847 chr3:49048691(+) A-G intron -    22484847 chr3:49048721(+) A-G intron -    22484847 chr3:49048726(+) A-G intron -    22484847 chr3:49048734(+) A-G intron -    22484847 chr3:49048773(+) A-G intron -    22484847 chr3:49048774(+) A-G intron -    22484847 chr3:49048780(+) A-G intron -    22484847 chr3:49048786(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WDR6	chr3:49044534-49044535(+) m6A 5'UTR       24284625//24981863 chr3:49044565-49044566(+) m6A 5'UTR       24981863 chr3:49044581-49044582(+) m6A 5'UTR       24981863 chr3:49044721-49044722(+) m6A 5'UTR       - chr3:49044880-49044881(+) m6A 5'UTR//CDS//exon       24284625//24981863//22575960 chr3:49044949-49044950(+) m6A 5'UTR//CDS//exon       24284625//24981863//22575960//22608085 chr3:49045549-49045550(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr3:49049100-49049101(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49049139-49049140(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049196-49049197(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049239-49049240(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049266-49049267(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49049307-49049308(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049318-49049319(+) Tm 3'UTR//CDS//exon//intron       - chr3:49049433-49049434(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049550-49049551(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049557-49049558(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49049655-49049656(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49049851-49049852(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49050130-49050131(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49050255-49050256(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050260-49050261(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050529-49050530(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050546-49050547(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49050807-49050808(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49050888-49050889(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr3:49051212-49051213(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr3:49051428-49051429(+) m6A 3'UTR//5'UTR//CDS//exon       24284625//24209618//22575960//22608085 chr3:49051500-49051501(+) m6A 3'UTR//CDS//exon       24284625//22575960 chr3:49051536-49051537(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051544-49051545(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051666-49051667(+) m6A 3'UTR//CDS//exon       24284625 chr3:49051749-49051750(+) m6A exon//intron       24284625 chr3:49051756-49051757(+) m6A exon//intron       24284625 chr3:49051864-49051865(+) m6A 3'UTR//CDS//exon       24284625 chr3:49052100-49052101(+) m6A 3'UTR//CDS//exon       24284625 chr3:49052585-49052586(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052638-49052639(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052767-49052768(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr3:49052913-49052914(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052918-49052919(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052930-49052931(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49052990-49052991(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053044-49053045(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053109-49053110(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:49053295-49053296(+) m6A 3'UTR       24284625//24981863//22575960 chr3:49053311-49053312(+) m6A 3'UTR       24284625//24981863//22575960 chr3:49053317-49053318(+) m6A 3'UTR       24284625//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WDR6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: WDR6

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//PITA//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.