Basic Information:

  VIRBase ID:  

VHID00419442

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          CCNI:  NM_001348139     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	CCNI
miRBase Accession/Entrez ID	MIMAT0010132	10983
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCNI1//CYC1//CYI

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCNI	chr4:77976428(-) A-I      NonSyn:Met->Val chr4:77986020(-) A-I      ncRNA chr4:77986075(-) A-I      ncRNA chr4:77986046(-) A-I      ncRNA chr4:77986025(-) A-I      ncRNA chr4:77986008(-) A-I      ncRNA chr4:77986002(-) A-I      ncRNA chr4:77976433(-) A-I      NonSyn:His->Arg chr4:77985969(-) A-I      ncRNA chr4:77976405(-) A-I      Syn:Gln->Gln chr4:77985965(-) A-I      ncRNA chr4:77985948(-) A-I      ncRNA chr4:77976371(-) A-I      NonSyn:Ser->Gly chr4:77985918(-) A-I      ncRNA chr4:77976418(-) A-I      NonSyn:Asn->Ser chr4:77987027(-) A-I      intronic chr4:77987192(-) A-I      intronic chr4:77987207(-) A-I      intronic chr4:77988752(-) A-I      intronic chr4:77988755(-) A-I      intronic chr4:77985339(-) A-I      intronic chr4:77985357(-) A-I      intronic chr4:77987070(-) A-I      intronic chr4:77987130(-) A-I      intronic chr4:77987132(-) A-I      intronic chr4:77987168(-) A-I      intronic chr4:77987171(-) A-I      intronic chr4:77987210(-) A-I      intronic chr4:77991243(-) A-I      intronic chr4:77991268(-) A-I      intronic chr4:77991273(-) A-I      intronic chr4:77982891(-) A-I      intronic chr4:77982899(-) A-I      intronic chr4:77980681(-) A-I      intronic chr4:77991287(-) A-I      intronic chr4:77980333(-) A-I      intronic chr4:77983502(-) A-I      intronic chr4:77983499(-) A-I      intronic chr4:77985232(-) A-I      intronic chr4:77983515(-) A-I      intronic chr4:77980348(-) A-I      intronic chr4:77980354(-) A-I      intronic chr4:77980656(-) A-I      intronic chr4:77980670(-) A-I      intronic chr4:77983027(-) A-I      intronic chr4:77980689(-) A-I      intronic chr4:77980699(-) A-I      intronic chr4:77980755(-) A-I      intronic chr4:77980763(-) A-I      intronic chr4:77976668(-) A-I      intronic chr4:77976708(-) A-I      intronic chr4:77976768(-) A-I      intronic chr4:77976790(-) A-I      intronic chr4:77977832(-) A-I      intronic chr4:77977854(-) A-I      intronic chr4:77983601(-) A-I      intronic chr4:77986996(-) A-I      intronic chr4:77987197(-) A-I      intronic chr4:77977950(-) A-I      intronic chr4:77980787(-) A-I      intronic chr4:77985229(-) A-I      intronic chr4:77985223(-) A-I      intronic chr4:77985215(-) A-I      intronic chr4:77985178(-) A-I      intronic chr4:77984705(-) A-I      intronic chr4:77982947(-) A-I      intronic chr4:77978011(-) A-I      intronic chr4:77984675(-) A-I      intronic chr4:77978017(-) A-I      intronic chr4:77984661(-) A-I      intronic chr4:77984653(-) A-I      intronic chr4:77980795(-) A-I      intronic chr4:77978025(-) A-I      intronic chr4:77979283(-) A-I      intronic chr4:77979291(-) A-I      intronic chr4:77979422(-) A-I      intronic chr4:77981915(-) A-I      intronic chr4:77981923(-) A-I      intronic chr4:77981924(-) A-I      intronic chr4:77976884(-) A-I      intronic chr4:77982920(-) A-I      intronic chr4:77976788(-) A-I      intronic chr4:77982934(-) A-I      intronic chr4:77976813(-) A-I      intronic chr4:77983028(-) A-I      intronic chr4:77982951(-) A-I      intronic chr4:77983006(-) A-I      intronic chr4:77983088(-) A-I      intronic chr4:77982997(-) A-I      intronic chr4:77976748(-) A-I      intronic chr4:77976784(-) A-I      intronic chr4:77986005(-) A-I      ncRNA chr4:77976793(-) A-I      intronic chr4:77976744(-) A-I      intronic chr4:77977864(-) A-I      intronic chr4:77982990(-) A-I      intronic chr4:77982987(-) A-I      intronic chr4:77976757(-) A-I      intronic chr4:77985929(-) A-I      ncRNA chr4:77988736(-) A-I      intronic chr4:77985930(-) A-I      ncRNA chr4:77977878(-) A-I      intronic chr4:77983017(-) A-I      intronic chr4:77983101(-) A-I      intronic chr4:77985900(-) A-I      ncRNA chr4:77976824(-) A-I      intronic chr4:77985944(-) A-I      ncRNA chr4:77982991(-) A-I      intronic chr4:77982961(-) A-I      intronic chr4:77988130(-) A-I      intronic chr4:77976852(-) A-I      intronic chr4:77976847(-) A-I      intronic chr4:77976833(-) A-I      intronic chr4:77983000(-) A-I      intronic chr4:77982992(-) A-I      intronic chr4:77987087(-) A-I      intronic chr4:77985333(-) A-I      intronic chr4:77989222(-) A-I      intronic chr4:77985313(-) A-I      intronic chr4:77989248(-) A-I      intronic chr4:77982059(-) A-I      intronic chr4:77985151(-) A-I      intronic chr4:77985176(-) A-I      intronic chr4:77987002(-) A-I      intronic chr4:77981916(-) A-I      intronic chr4:77989150(-) A-I      intronic chr4:77983661(-) A-I      intronic chr4:77977973(-) A-I      intronic chr4:77988772(-) A-I      intronic chr4:77982955(-) A-I      intronic chr4:77981799(-) A-I      intronic chr4:77990319(-) A-I      intronic chr4:77982078(-) A-I      intronic chr4:77976798(-) A-I      intronic chr4:77988887(-) A-I      intronic chr4:77988854(-) A-I      intronic chr4:77987167(-) A-I      intronic chr4:77987202(-) A-I      intronic chr4:77985173(-) A-I      intronic chr4:77983596(-) A-I      intronic chr4:77988699(-) A-I      intronic chr4:77987240(-) A-I      intronic chr4:77985296(-) A-I      intronic chr4:77984678(-) A-I      intronic chr4:77979399(-) A-I      intronic chr4:77979336(-) A-I      intronic chr4:77976799(-) A-I      intronic chr4:77991309(-) A-I      intronic chr4:77987008(-) A-I      intronic chr4:77985284(-) A-I      intronic chr4:77988693(-) A-I      intronic chr4:77984589(-) A-I      intronic chr4:77991225(-) A-I      intronic chr4:77970797(-) A-I      intronic chr4:77987056(-) A-I      intronic chr4:77983516(-) A-I      intronic chr4:77985150(-) A-I      intronic chr4:77990406(-) A-I      intronic chr4:77977858(-) A-I      intronic chr4:77979342(-) A-I      intronic chr4:77988782(-) A-I      intronic chr4:77979245(-) A-I      intronic chr4:77977940(-) A-I      intronic chr4:77976683(-) A-I      intronic chr4:77988302(-) A-I      intronic chr4:77989250(-) A-I      intronic chr4:77989218(-) A-I      intronic chr4:77983547(-) A-I      intronic chr4:77988740(-) A-I      intronic chr4:77990327(-) A-I      intronic chr4:77983517(-) A-I      intronic chr4:77987159(-) A-I      intronic chr4:77976823(-) A-I      intronic chr4:77976796(-) A-I      intronic chr4:77979380(-) A-I      intronic chr4:77970659(-) A-I      intronic chr4:77987191(-) A-I      intronic chr4:77983094(-) A-I      intronic chr4:77979396(-) A-I      intronic chr4:77989209(-) A-I      intronic chr4:77977871(-) A-I      intronic chr4:77989080(-) A-I      intronic chr4:77988811(-) A-I      intronic chr4:77977946(-) A-I      intronic chr4:77982919(-) A-I      intronic chr4:77985160(-) A-I      intronic chr4:77981756(-) A-I      intronic chr4:77977881(-) A-I      intronic chr4:77981873(-) A-I      intronic chr4:77981713(-) A-I      intronic chr4:77985925(-) A-I      ncRNA chr4:77986106(-) A-I      ncRNA chr4:77986011(-) A-I      ncRNA chr4:77986000(-) A-I      ncRNA chr4:77986065(-) A-I      ncRNA chr4:77985996(-) A-I      ncRNA chr4:77985939(-) A-I      ncRNA chr4:77986026(-) A-I      ncRNA chr4:77986010(-) A-I      ncRNA chr4:77986007(-) A-I      ncRNA chr4:77986083(-) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCNI	chr4:77979680(-) A-I exon CDS    19478186   //21960545 chr4:77983094(-) A-I intron -    22028664   //22327324 chr4:77976744(-) A-I intron -    22028664 chr4:77976748(-) A-I intron -    22028664 chr4:77976757(-) A-I intron -    22028664 chr4:77976784(-) A-I intron -    22028664 chr4:77976788(-) A-I intron -    22028664 chr4:77976793(-) A-I intron -    22028664 chr4:77976796(-) A-I intron -    22028664 chr4:77976813(-) A-I intron -    22028664 chr4:77976823(-) A-I intron -    22028664 chr4:77976824(-) A-I intron -    22028664 chr4:77976833(-) A-I intron -    22028664 chr4:77976847(-) A-I intron -    22028664 chr4:77976852(-) A-I intron -    22028664 chr4:77976884(-) A-I intron -    22028664 chr4:77982919(-) A-I intron -    22028664 chr4:77982920(-) A-I intron -    22028664 chr4:77982934(-) A-I intron -    22028664 chr4:77982951(-) A-I intron -    22028664 chr4:77982955(-) A-I intron -    22028664 chr4:77982961(-) A-I intron -    22028664 chr4:77982987(-) A-I intron -    22028664 chr4:77982990(-) A-I intron -    22028664 chr4:77982991(-) A-I intron -    22028664 chr4:77982992(-) A-I intron -    22028664 chr4:77982997(-) A-I intron -    22028664 chr4:77983000(-) A-I intron -    22028664 chr4:77983006(-) A-I intron -    22028664 chr4:77983017(-) A-I intron -    22028664 chr4:77983028(-) A-I intron -    22028664 chr4:77983088(-) A-I intron -    22028664 chr4:77983095(-) A-I intron -    22028664 chr4:77983101(-) A-I intron -    22028664 chr4:77980220(-) A-I intron -    21960545 chr4:77987056(-) A-I intron -    21960545 chr4:77997047(-) C-T intron -    21725310 chr4:77976617(-) G-A intron -    22484847 chr4:77977878(-) A-G intron -    22484847 chr4:77977946(-) A-G intron -    22484847 chr4:77977973(-) A-G intron -    22484847 chr4:77982955(-) A-G intron -    22484847 chr4:77983094(-) A-G intron -    22484847 chr4:77983596(-) A-G intron -    22484847 chr4:77983651(-) A-G intron -    22484847 chr4:77985150(-) A-G intron -    22484847 chr4:77985151(-) A-G intron -    22484847 chr4:77985173(-) A-G intron -    22484847 chr4:77986011(-) A-G intron -    22484847 chr4:77986014(-) A-G intron -    22484847 chr4:77987008(-) A-G intron -    22484847 chr4:77987056(-) A-G intron -    22484847 chr4:77987096(-) A-G intron -    22484847 chr4:77987191(-) A-G intron -    22484847 chr4:77987202(-) A-G intron -    22484847 chr4:77987240(-) A-G intron -    22484847 chr4:77988746(-) A-G intron -    22484847 chr4:77988817(-) C-A intron -    22484847 chr4:77989080(-) A-G intron -    22484847 chr4:77991308(-) A-G intron -    22484847 chr4:77991309(-) A-G intron -    22484847 chr4:77993659(-) T-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCNI	chr4:77968552-77968553(-) m6A 3'UTR       26404942 chr4:77968622-77968623(-) m6A 3'UTR       26404942 chr4:77968913-77968914(-) m6A 3'UTR       26404942 chr4:77968959-77968960(-) m6A 3'UTR       26404942 chr4:77969134-77969135(-) m6A 3'UTR       26404942 chr4:77969145-77969146(-) m6A 3'UTR       26404942 chr4:77969180-77969181(-) m6A 3'UTR       24981863//26404942 chr4:77969234-77969235(-) m6A 3'UTR       24981863//26404942 chr4:77969308-77969309(-) Am 3'UTR       - chr4:77969314-77969315(-) m6A 3'UTR       24981863//26404942 chr4:77969332-77969333(-) m6A 3'UTR       24981863//26404942 chr4:77969342-77969343(-) m6A 3'UTR       24981863//26404942 chr4:77969416-77969417(-) m6A CDS       24981863//26404942 chr4:77969425-77969426(-) m6A CDS       24981863//26404942 chr4:77969550-77969551(-) m6A CDS       24981863//26404942 chr4:77969630-77969631(-) m6A CDS       24981863//26404942//22575960 chr4:77969642-77969643(-) m6A CDS       24981863//26404942//22575960 chr4:77977189-77977190(-) Gm 3'UTR//CDS//exon       - chr4:77979709-77979710(-) m6A CDS//exon//intron       - chr4:77979740-77979741(-) m6A CDS//exon//intron       - chr4:77985928-77985929(-) m6A exon//intron       - chr4:77995963-77995964(-) m6A 5'UTR//intron       24981863 chr4:77996429-77996430(-) m6A 5'UTR//intron       24981863 chr4:77996465-77996466(-) m6A 5'UTR//intron       24981863 chr4:77996866-77996867(-) m6A 5'UTR       27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CCNI	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: CCNI

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.