Basic Information:

  VIRBase ID:  

VHID00418618

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          UBE2D3:  NM_181893     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	UBE2D3
miRBase Accession/Entrez ID	MIMAT0010132	7323
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	E2(17)KB3//UBC4/5//UBCH5C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBE2D3	chr4:103731701(-) A-I      intronic chr4:103736368(-) A-I      intronic chr4:103736293(-) A-I      intronic chr4:103755703(-) A-I      intronic chr4:103736372(-) A-I      intronic chr4:103736369(-) A-I      intronic chr4:103736297(-) A-I      intronic chr4:103736378(-) A-I      intronic chr4:103731634(-) A-I      intronic chr4:103736379(-) A-I      intronic chr4:103731704(-) A-I      intronic chr4:103731706(-) A-I      intronic chr4:103732264(-) A-I      intronic chr4:103732446(-) A-I      intronic chr4:103732659(-) A-I      intronic chr4:103732690(-) A-I      intronic chr4:103734436(-) A-I      intronic chr4:103735506(-) A-I      intronic chr4:103735518(-) A-I      intronic chr4:103735554(-) A-I      intronic chr4:103789335(-) A-I      intronic chr4:103735567(-) A-I      intronic chr4:103736277(-) A-I      intronic chr4:103736478(-) A-I      intronic chr4:103740244(-) A-I      intronic chr4:103740296(-) A-I      intronic chr4:103740313(-) A-I      intronic chr4:103740365(-) A-I      intronic chr4:103740375(-) A-I      intronic chr4:103740485(-) A-I      intronic chr4:103755670(-) A-I      intronic chr4:103755681(-) A-I      intronic chr4:103736323(-) A-I      intronic chr4:103735606(-) A-I      intronic chr4:103732617(-) A-I      intronic chr4:103732403(-) A-I      intronic chr4:103732379(-) A-I      intronic chr4:103731769(-) A-I      intronic chr4:103731753(-) A-I      intronic chr4:103731710(-) A-I      intronic chr4:103731708(-) A-I      intronic chr4:103731663(-) A-I      intronic chr4:103755714(-) A-I      intronic chr4:103759193(-) A-I      intronic chr4:103777351(-) A-I      intronic chr4:103778989(-) A-I      intronic chr4:103783159(-) A-I      intronic chr4:103784407(-) A-I      intronic chr4:103788892(-) A-I      intronic chr4:103789306(-) A-I      intronic chr4:103789327(-) A-I      intronic chr4:103789358(-) A-I      intronic chr4:103786573(-) A-I      intronic chr4:103784319(-) A-I      intronic chr4:103736405(-) A-I      intronic chr4:103733328(-) A-I      intronic chr4:103732776(-) A-I      intronic chr4:103732825(-) A-I      intronic chr4:103779026(-) A-I      intronic chr4:103732716(-) A-I      intronic chr4:103735584(-) A-I      intronic chr4:103733395(-) A-I      intronic chr4:103776716(-) A-I      intronic chr4:103770280(-) A-I      intronic chr4:103736439(-) A-I      intronic chr4:103732441(-) A-I      intronic chr4:103732648(-) A-I      intronic chr4:103776831(-) A-I      intronic chr4:103777401(-) A-I      intronic chr4:103735687(-) A-I      intronic chr4:103731647(-) A-I      intronic chr4:103732408(-) A-I      intronic chr4:103784802(-) A-I      intronic chr4:103767872(-) A-I      intronic chr4:103734422(-) A-I      intronic chr4:103732755(-) A-I      intronic chr4:103755819(-) A-I      intronic chr4:103732375(-) A-I      intronic chr4:103789341(-) A-I      intronic chr4:103735697(-) A-I      intronic chr4:103788847(-) A-I      intronic chr4:103731669(-) A-I      intronic chr4:103732673(-) A-I      intronic chr4:103770328(-) A-I      intronic chr4:103731735(-) A-I      intronic chr4:103770281(-) A-I      intronic chr4:103732301(-) A-I      intronic chr4:103776726(-) A-I      intronic chr4:103755823(-) A-I      intronic chr4:103777360(-) A-I      intronic chr4:103733425(-) A-I      intronic chr4:103788874(-) A-I      intronic chr4:103776830(-) A-I      intronic chr4:103765485(-) A-I      intronic chr4:103731718(-) A-I      intronic chr4:103732302(-) A-I      intronic chr4:103734467(-) A-I      intronic chr4:103788873(-) A-I      intronic chr4:103768938(-) A-I      intronic chr4:103732371(-) A-I      intronic chr4:103784753(-) A-I      intronic chr4:103768874(-) A-I      intronic chr4:103732634(-) A-I      intronic chr4:103736333(-) A-I      intronic chr4:103735574(-) A-I      intronic chr4:103769006(-) A-I      intronic chr4:103732691(-) A-I      intronic chr4:103732613(-) A-I      intronic chr4:103735733(-) A-I      intronic chr4:103731740(-) A-I      intronic chr4:103732815(-) A-I      intronic chr4:103731703(-) A-I      intronic chr4:103732451(-) A-I      intronic chr4:103732651(-) A-I      intronic chr4:103736329(-) A-I      intronic chr4:103731654(-) A-I      intronic chr4:103736268(-) A-I      intronic chr4:103732244(-) A-I      intronic chr4:103732676(-) A-I      intronic chr4:103732420(-) A-I      intronic chr4:103768899(-) A-I      intronic chr4:103732256(-) A-I      intronic chr4:103763539(-) A-I      intronic chr4:103733373(-) A-I      intronic chr4:103732250(-) A-I      intronic chr4:103732803(-) A-I      intronic chr4:103732300(-) A-I      intronic chr4:103735739(-) A-I      intronic chr4:103731739(-) A-I      intronic chr4:103735508(-) A-I      intronic chr4:103767076(-) A-I      intronic chr4:103734455(-) A-I      intronic chr4:103725212(-) A-I      intronic chr4:103735741(-) A-I      intronic chr4:103736365(-) A-I      intronic chr4:103736406(-) A-I      intronic chr4:103732762(-) A-I      intronic chr4:103732714(-) A-I      intronic chr4:103740456(-) A-I      intronic chr4:103736322(-) A-I      intronic chr4:103736306(-) A-I      intronic chr4:103731641(-) A-I      intronic chr4:103774438(-) A-I      intronic chr4:103732635(-) A-I      intronic chr4:103768893(-) A-I      intronic chr4:103732823(-) A-I      intronic chr4:103770322(-) A-I      intronic chr4:103733429(-) A-I      intronic chr4:103732391(-) A-I      intronic chr4:103734481(-) A-I      intronic chr4:103788844(-) A-I      intronic chr4:103784345(-) A-I      intronic chr4:103735486(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBE2D3	chr4:103731641(-) A-I intron -    15342557 chr4:103731654(-) A-I intron -    15342557 chr4:103731669(-) A-I intron -    15342557 chr4:103731698(-) A-I intron -    15342557   //21960545 chr4:103731705(-) A-I intron -    15342557 chr4:103732173(-) A-I intron -    15342557 chr4:103732199(-) A-I intron -    15342557 chr4:103732244(-) A-I intron -    15342557 chr4:103732256(-) A-I intron -    15342557 chr4:103732287(-) A-I intron -    15342557 chr4:103732371(-) A-I intron -    15342557 chr4:103732375(-) A-I intron -    15342557 chr4:103732387(-) A-I intron -    15342557 chr4:103732391(-) A-I intron -    15342557 chr4:103732408(-) A-I intron -    15342557 chr4:103732420(-) A-I intron -    15342557 chr4:103732421(-) A-I intron -    15342557 chr4:103732451(-) A-I intron -    15342557 chr4:103732582(-) A-I intron -    15342557 chr4:103732604(-) A-I intron -    15342557 chr4:103732613(-) A-I intron -    15342557 chr4:103732648(-) A-I intron -    15342557 chr4:103732651(-) A-I intron -    15342557 chr4:103732656(-) A-I intron -    15342557 chr4:103732673(-) A-I intron -    15342557 chr4:103732676(-) A-I intron -    15342557 chr4:103732714(-) A-I intron -    15342557 chr4:103732716(-) A-I intron -    15342557 chr4:103732726(-) A-I intron -    15342557 chr4:103732762(-) A-I intron -    15342557 chr4:103732776(-) A-I intron -    15342557 chr4:103732803(-) A-I intron -    15342557 chr4:103732821(-) A-I intron -    15342557   //21960545 chr4:103733328(-) A-I intron -    15342557   //22327324 chr4:103733395(-) A-I intron -    15342557 chr4:103733429(-) A-I intron -    21960545 chr4:103734481(-) A-I intron -    21960545 chr4:103734482(-) A-I intron -    21960545 chr4:103734488(-) A-I intron -    21960545 chr4:103726026(-) T-C intron -    22484847 chr4:103731739(-) A-G intron -    22484847 chr4:103731740(-) A-G intron -    22484847 chr4:103732387(-) A-G intron -    22484847 chr4:103732495(-) A-C intron -    22484847 chr4:103732496(-) C-T intron -    22484847 chr4:103732613(-) A-G intron -    22484847 chr4:103732651(-) A-G intron -    22484847 chr4:103732656(-) A-G intron -    22484847 chr4:103732676(-) A-G intron -    22484847 chr4:103732714(-) A-G intron -    22484847 chr4:103732776(-) A-G intron -    22484847 chr4:103732821(-) A-G intron -    22484847 chr4:103732825(-) A-G intron -    22484847 chr4:103733328(-) A-G intron -    22484847 chr4:103733429(-) A-G intron -    22484847 chr4:103734467(-) A-G intron -    22484847 chr4:103734481(-) A-G intron -    22484847 chr4:103734482(-) A-G intron -    22484847 chr4:103734488(-) A-G intron -    22484847 chr4:103734498(-) A-G intron -    22484847 chr4:103735570(-) A-G intron -    22484847 chr4:103736318(-) T-C intron -    22484847 chr4:103765485(-) A-G intron -    22484847 chr4:103765530(-) A-G intron -    22484847 chr4:103767048(-) T-C intron -    22484847 chr4:103767909(-) T-C intron -    22484847 chr4:103767914(-) T-C intron -    22484847 chr4:103768542(-) T-C intron -    22484847 chr4:103769969(-) A-G intron -    22484847 chr4:103770280(-) A-G intron -    22484847 chr4:103770322(-) A-G intron -    22484847 chr4:103770328(-) A-G intron -    22484847 chr4:103776830(-) A-G intron -    22484847 chr4:103777401(-) A-G intron -    22484847 chr4:103788935(-) A-G intron -    22484847 chr4:103731066(-) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBE2D3	chr4:103715541-103715542(-) m6A 3'UTR       27773535 chr4:103715605-103715606(-) m6A 3'UTR       27773535 chr4:103715653-103715654(-) m6A 3'UTR       27773535 chr4:103715705-103715706(-) m6A 3'UTR       27773535 chr4:103718249-103718250(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718255-103718256(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718330-103718331(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085 chr4:103718343-103718344(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085 chr4:103718365-103718366(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718384-103718385(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718406-103718407(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//27773535//22608085 chr4:103718473-103718474(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718527-103718528(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr4:103718591-103718592(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr4:103720108-103720109(-) m6A CDS//intron       24284625 chr4:103723726-103723727(-) m6A 3'UTR//CDS//exon       27773535 chr4:103723739-103723740(-) m6A 3'UTR//CDS//exon       27773535 chr4:103730233-103730234(-) m6A 3'UTR//intron       27773535 chr4:103730831-103730832(-) m6A 3'UTR//CDS//exon       - chr4:103731009-103731010(-) m6A 5'UTR//CDS//exon       - chr4:103731074-103731075(-) m6A exon//intron       - chr4:103747715-103747716(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828 chr4:103747758-103747759(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828//22575960 chr4:103747857-103747858(-) m6A 5'UTR//exon//intron       24981863//27773535//27371828//22575960 chr4:103747985-103747986(-) m6A 5'UTR//exon//intron       24284625//24981863//27773535 chr4:103748068-103748069(-) m6A 5'UTR//exon//intron       24284625//24209618//24981863//27773535 chr4:103748191-103748192(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535 chr4:103748197-103748198(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535 chr4:103748691-103748692(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828 chr4:103748769-103748770(-) m6A 5'UTR//intron       25456834//24981863//27371828 chr4:103748874-103748875(-) m1A 5'UTR//intron       26863196 chr4:103749091-103749092(-) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr4:103749180-103749181(-) m6A 5'UTR//intron       24284625//24981863//22608085 chr4:103749204-103749205(-) m6A 5'UTR//intron       24284625//24981863//22608085 chr4:103749226-103749227(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	UBE2D3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: UBE2D3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.