Basic Information:

  VIRBase ID:  

VHID00418046

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART22:  MIMAT0010132          NPM1:  NR_149149     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART22	NPM1
miRBase Accession/Entrez ID	MIMAT0010132	4869
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B23//NPM

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NPM1	chr5:170828282(+) A-I      intronic chr5:170828210(+) A-I      intronic chr5:170828161(+) A-I      intronic chr5:170827661(+) A-I      intronic chr5:170827635(+) A-I      intronic chr5:170827626(+) A-I      intronic chr5:170827622(+) A-I      intronic chr5:170825708(+) A-I      intronic chr5:170827618(+) A-I      intronic chr5:170827602(+) A-I      intronic chr5:170827600(+) A-I      intronic chr5:170827590(+) A-I      intronic chr5:170827587(+) A-I      intronic chr5:170821358(+) A-I      intronic chr5:170821361(+) A-I      intronic chr5:170821392(+) A-I      intronic chr5:170821406(+) A-I      intronic chr5:170821973(+) A-I      intronic chr5:170821987(+) A-I      intronic chr5:170822021(+) A-I      intronic chr5:170822030(+) A-I      intronic chr5:170822090(+) A-I      intronic chr5:170822433(+) A-I      intronic chr5:170822470(+) A-I      intronic chr5:170823735(+) A-I      intronic chr5:170823789(+) A-I      intronic chr5:170823862(+) A-I      intronic chr5:170823883(+) A-I      intronic chr5:170823897(+) A-I      intronic chr5:170823898(+) A-I      intronic chr5:170823927(+) A-I      intronic chr5:170823960(+) A-I      intronic chr5:170825617(+) A-I      intronic chr5:170825733(+) A-I      intronic chr5:170825621(+) A-I      intronic chr5:170823199(+) A-I      intronic chr5:170827597(+) A-I      intronic chr5:170825660(+) A-I      intronic chr5:170837083(+) A-I      intronic chr5:170837076(+) A-I      intronic chr5:170836449(+) A-I      intronic chr5:170836405(+) A-I      intronic chr5:170836372(+) A-I      intronic chr5:170832009(+) A-I      intronic chr5:170828680(+) A-I      intronic chr5:170828540(+) A-I      intronic chr5:170828273(+) A-I      intronic chr5:170828271(+) A-I      intronic chr5:170828268(+) A-I      intronic chr5:170828204(+) A-I      intronic chr5:170828155(+) A-I      intronic chr5:170828142(+) A-I      intronic chr5:170826503(+) A-I      intronic chr5:170826405(+) A-I      intronic chr5:170826035(+) A-I      intronic chr5:170826029(+) A-I      intronic chr5:170826007(+) A-I      intronic chr5:170825897(+) A-I      intronic chr5:170825636(+) A-I      intronic chr5:170836404(+) A-I      intronic chr5:170828283(+) A-I      intronic chr5:170823786(+) A-I      intronic chr5:170828668(+) A-I      intronic chr5:170822007(+) A-I      intronic chr5:170822024(+) A-I      intronic chr5:170828185(+) A-I      intronic chr5:170822443(+) A-I      intronic chr5:170825619(+) A-I      intronic chr5:170828567(+) A-I      intronic chr5:170820936(+) A-I      intronic chr5:170822397(+) A-I      intronic chr5:170825994(+) A-I      intronic chr5:170825524(+) A-I      intronic chr5:170822104(+) A-I      intronic chr5:170825996(+) A-I      intronic chr5:170826038(+) A-I      intronic chr5:170836785(+) A-I      intronic chr5:170826502(+) A-I      intronic chr5:170828255(+) A-I      intronic chr5:170822128(+) A-I      intronic chr5:170836477(+) A-I      intronic chr5:170821933(+) A-I      intronic chr5:170821439(+) A-I      intronic chr5:170820859(+) A-I      intronic chr5:170828206(+) A-I      intronic chr5:170836395(+) A-I      intronic chr5:170826075(+) A-I      intronic chr5:170836958(+) A-I      intronic chr5:170825984(+) A-I      intronic chr5:170828625(+) A-I      intronic chr5:170822484(+) A-I      intronic chr5:170828128(+) A-I      intronic chr5:170822487(+) A-I      intronic chr5:170836409(+) A-I      intronic chr5:170826509(+) A-I      intronic chr5:170825917(+) A-I      intronic chr5:170822133(+) A-I      intronic chr5:170836928(+) A-I      intronic chr5:170822489(+) A-I      intronic chr5:170828241(+) A-I      intronic chr5:170828675(+) A-I      intronic chr5:170822077(+) A-I      intronic chr5:170825523(+) A-I      intronic chr5:170836967(+) A-I      intronic chr5:170825588(+) A-I      intronic chr5:170836394(+) A-I      intronic chr5:170822036(+) A-I      intronic chr5:170828494(+) A-I      intronic chr5:170832011(+) A-I      intronic chr5:170824933(+) A-I      intronic chr5:170832103(+) A-I      intronic chr5:170828212(+) A-I      intronic chr5:170826383(+) A-I      intronic chr5:170825736(+) A-I      intronic chr5:170821981(+) A-I      intronic chr5:170825623(+) A-I      intronic chr5:170836400(+) A-I      intronic chr5:170826055(+) A-I      intronic chr5:170826437(+) A-I      intronic chr5:170825741(+) A-I      intronic chr5:170828602(+) A-I      intronic chr5:170825599(+) A-I      intronic chr5:170828242(+) A-I      intronic chr5:170823857(+) A-I      intronic chr5:170822514(+) A-I      intronic chr5:170821231(+) A-I      intronic chr5:170836397(+) A-I      intronic chr5:170836911(+) A-I      intronic chr5:170827613(+) A-I      intronic chr5:170826493(+) A-I      intronic chr5:170825598(+) A-I      intronic chr5:170825517(+) A-I      intronic chr5:170828566(+) A-I      intronic chr5:170828667(+) A-I      intronic chr5:170825613(+) A-I      intronic chr5:170836997(+) A-I      intronic chr5:170826117(+) A-I      intronic chr5:170828274(+) A-I      intronic chr5:170825928(+) A-I      intronic chr5:170836462(+) A-I      intronic chr5:170828211(+) A-I      intronic chr5:170825668(+) A-I      intronic chr5:170832006(+) A-I      intronic chr5:170820939(+) A-I      intronic chr5:170828570(+) A-I      intronic chr5:170822027(+) A-I      intronic chr5:170825641(+) A-I      intronic chr5:170825887(+) A-I      intronic chr5:170828251(+) A-I      intronic chr5:170821233(+) A-I      intronic chr5:170828152(+) A-I      intronic chr5:170831995(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NPM1	chr5:170836785(+) A-I intron -    15258596 chr5:170836911(+) A-I intron -    15258596 chr5:170836928(+) A-I intron -    15258596 chr5:170825641(+) A-I intron -    22327324 chr5:170836400(+) A-I intron -    22327324 chr5:170823856(+) A-I intron -    21960545 chr5:170828615(+) A-I intron -    21960545 chr5:170836335(+) A-I intron -    21960545 chr5:170817743(+) C-T intron -    22484847 chr5:170821138(+) T-C intron -    22484847 chr5:170821139(+) G-A intron -    22484847 chr5:170821359(+) A-G intron -    22484847 chr5:170821981(+) A-G intron -    22484847 chr5:170822007(+) A-G intron -    22484847 chr5:170822023(+) A-G intron -    22484847 chr5:170822024(+) A-G intron -    22484847 chr5:170822025(+) A-G intron -    22484847 chr5:170822378(+) G-A intron -    22484847 chr5:170822397(+) A-G intron -    22484847 chr5:170822443(+) A-G intron -    22484847 chr5:170822484(+) A-G intron -    22484847 chr5:170822487(+) A-G intron -    22484847 chr5:170822489(+) A-G intron -    22484847 chr5:170822514(+) A-G intron -    22484847 chr5:170823856(+) A-G intron -    22484847 chr5:170823857(+) A-G intron -    22484847 chr5:170823950(+) T-C intron -    22484847 chr5:170824806(+) C-T intron -    22484847 chr5:170824823(+) G-T intron -    22484847 chr5:170824892(+) T-G intron -    22484847 chr5:170824933(+) A-G intron -    22484847 chr5:170824947(+) C-A intron -    22484847 chr5:170824948(+) A-C intron -    22484847 chr5:170825504(+) T-G intron -    22484847 chr5:170825517(+) A-G intron -    22484847 chr5:170825538(+) A-G intron -    22484847 chr5:170825588(+) A-G intron -    22484847 chr5:170825628(+) A-G intron -    22484847 chr5:170825641(+) A-G intron -    22484847 chr5:170825654(+) A-G intron -    22484847 chr5:170825917(+) A-G intron -    22484847 chr5:170825994(+) A-G intron -    22484847 chr5:170826020(+) A-G intron -    22484847 chr5:170826021(+) A-G intron -    22484847 chr5:170826058(+) A-G intron -    22484847 chr5:170826383(+) A-G intron -    22484847 chr5:170826509(+) A-G intron -    22484847 chr5:170827504(+) G-A intron -    22484847 chr5:170828147(+) A-G intron -    22484847 chr5:170828152(+) A-G intron -    22484847 chr5:170828206(+) A-G intron -    22484847 chr5:170828219(+) A-G intron -    22484847 chr5:170828242(+) A-G intron -    22484847 chr5:170828255(+) A-G intron -    22484847 chr5:170828472(+) A-G intron -    22484847 chr5:170828566(+) A-G intron -    22484847 chr5:170828567(+) A-G intron -    22484847 chr5:170828570(+) A-G intron -    22484847 chr5:170828602(+) A-G intron -    22484847 chr5:170828615(+) A-G intron -    22484847 chr5:170828630(+) T-C intron -    22484847 chr5:170828667(+) A-G intron -    22484847 chr5:170831995(+) A-G intron -    22484847 chr5:170832059(+) A-G intron -    22484847 chr5:170836335(+) A-G intron -    22484847 chr5:170836396(+) A-G intron -    22484847 chr5:170836397(+) A-G intron -    22484847 chr5:170836398(+) A-G intron -    22484847 chr5:170836400(+) A-G intron -    22484847 chr5:170836450(+) A-G intron -    22484847 chr5:170836462(+) A-G intron -    22484847 chr5:170836898(+) A-G intron -    22484847 chr5:170836902(+) A-G intron -    22484847 chr5:170836911(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPM1	chr5:170814968-170814969(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814974-170814975(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814998-170814999(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170817061-170817062(+) m6A CDS//exon//intron       27773535//22575960 chr5:170817142-170817143(+) m6A exon//intron       27773535 chr5:170817155-170817156(+) m6A exon//intron       27773535 chr5:170818270-170818271(+) m6A exon//intron       - chr5:170818348-170818349(+) Y 5'UTR//CDS//exon       26075521 chr5:170818789-170818790(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819762-170819763(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819877-170819878(+) m6A exon//intron       24981863//27773535//22575960 chr5:170819928-170819929(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170827812-170827813(+) m6A exon//intron       24981863//27773535//22575960 chr5:170827897-170827898(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170827904-170827905(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170832307-170832308(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832325-170832326(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832335-170832336(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832344-170832345(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832355-170832356(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832372-170832373(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832430-170832431(+) m6A exon//intron       24981863//27773535//22575960 chr5:170832473-170832474(+) m6A exon//intron       24981863//27773535 chr5:170832696-170832697(+) m6A exon//intron       24981863 chr5:170832733-170832734(+) m6A exon//intron       24981863 chr5:170833409-170833410(+) m6A 3'UTR//intron       24981863 chr5:170833468-170833469(+) m6A 3'UTR//intron       24981863 chr5:170833506-170833507(+) m6A 3'UTR//intron       27773535 chr5:170833574-170833575(+) m6A 3'UTR//intron       27773535 chr5:170833626-170833627(+) m6A 3'UTR//intron       27773535 chr5:170837582-170837583(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837665-170837666(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837754-170837755(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837802-170837803(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837824-170837825(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837843-170837844(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837867-170837868(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NPM1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART22
Interactor2: NPM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//Targetscan
Support Database	VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.