Detail Information

Basic Information:


  VIRBase ID:  

VHID00413927

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART21-5p:           FAM126A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART21-5p FAM126A
miRBase
Accession/Entrez ID		 MIMAT0010130 84668
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - DRCTNNB1A//HCC//HLD5//HYCC1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR FAM126A
chr7:23024217(-) A-I      intronic
chr7:23005440(-) A-I      intronic
chr7:23005342(-) A-I      intronic
chr7:23004690(-) A-I      intronic
chr7:23009339(-) A-I      intronic
chr7:23024104(-) A-I      intronic
chr7:23008866(-) A-I      intronic
chr7:23011122(-) A-I      intronic
chr7:23011173(-) A-I      intronic
chr7:23011195(-) A-I      intronic
chr7:23015343(-) A-I      intronic
chr7:23015346(-) A-I      intronic
chr7:23015535(-) A-I      intronic
chr7:23015620(-) A-I      intronic
chr7:23044604(-) A-I      intronic
chr7:23008800(-) A-I      intronic
chr7:23024224(-) A-I      intronic
chr7:23024222(-) A-I      intronic
chr7:23044599(-) A-I      intronic
chr7:23029095(-) A-I      intronic
chr7:23015625(-) A-I      intronic
chr7:23024147(-) A-I      intronic
chr7:23024225(-) A-I      intronic
chr7:23026367(-) A-I      intronic
chr7:23027043(-) A-I      intronic
chr7:23009338(-) A-I      intronic
chr7:23009337(-) A-I      intronic
chr7:23009336(-) A-I      intronic
chr7:23009311(-) A-I      intronic
chr7:23008979(-) A-I      intronic
chr7:23008863(-) A-I      intronic
chr7:23008351(-) A-I      intronic
chr7:23005466(-) A-I      intronic
chr7:23015538(-) A-I      intronic
chr7:23029105(-) A-I      intronic
chr7:23024154(-) A-I      intronic
chr7:23024159(-) A-I      intronic
chr7:23008891(-) A-I      intronic
chr7:23008425(-) A-I      intronic
chr7:23026979(-) A-I      intronic
chr7:23024229(-) A-I      intronic
chr7:23024265(-) A-I      intronic
chr7:23009370(-) A-I      intronic
chr7:23005438(-) A-I      intronic
chr7:23029131(-) A-I      intronic
chr7:23015474(-) A-I      intronic
chr7:23029267(-) A-I      intronic
chr7:23005277(-) A-I      intronic
chr7:23009239(-) A-I      intronic
chr7:23004677(-) A-I      intronic
chr7:23008896(-) A-I      intronic
chr7:23008523(-) A-I      intronic
chr7:23022718(-) A-I      intronic
chr7:23029099(-) A-I      intronic
chr7:23008436(-) A-I      intronic
chr7:23015520(-) A-I      intronic
chr7:23015540(-) A-I      intronic
chr7:23004568(-) A-I      intronic
chr7:23035703(-) A-I      intronic
chr7:23024088(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED FAM126A
chr7:23005338(-) A-G intron -    22484847
chr7:23005438(-) A-G intron -    22484847
chr7:23005458(-) A-G intron -    22484847
chr7:23008425(-) A-G intron -    22484847
chr7:23008435(-) A-G intron -    22484847
chr7:23008436(-) A-G intron -    22484847
chr7:23008523(-) A-G intron -    22484847
chr7:23009240(-) A-G intron -    22484847
chr7:23009370(-) A-G intron -    22484847
chr7:23015474(-) A-G intron -    22484847
chr7:23015538(-) A-G intron -    22484847
chr7:23024154(-) A-G intron -    22484847
chr7:23024156(-) A-G intron -    22484847
chr7:23024159(-) A-G intron -    22484847
chr7:23024219(-) A-G intron -    22484847
chr7:23024229(-) A-G intron -    22484847
chr7:23024265(-) A-G intron -    22484847
chr7:23029059(-) A-G intron -    22484847
chr7:23029099(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase FAM126A
chr7:22981687-22981688(-) m6A 3'UTR       27773535
chr7:22981699-22981700(-) m6A 3'UTR       27773535
chr7:22981715-22981716(-) m6A 3'UTR       27773535
chr7:22981733-22981734(-) m6A 3'UTR       27773535
chr7:22981747-22981748(-) m6A 3'UTR       27773535
chr7:22982064-22982065(-) m6A 3'UTR       25456834
chr7:22982074-22982075(-) m6A 3'UTR       25456834
chr7:22982086-22982087(-) m6A 3'UTR       25456834//24981863
chr7:22982096-22982097(-) m6A 3'UTR       25456834//24981863
chr7:22982168-22982169(-) m6A 3'UTR       25456834
chr7:22983993-22983994(-) m6A 3'UTR       27773535
chr7:22984098-22984099(-) m6A 3'UTR       27773535
chr7:22984133-22984134(-) m6A 3'UTR       27773535
chr7:22984183-22984184(-) m6A 3'UTR       24981863//27773535
chr7:22984190-22984191(-) m6A 3'UTR       24981863//27773535
chr7:22984323-22984324(-) m6A 3'UTR       24981863//27773535//22608085
chr7:22984356-22984357(-) m6A 3'UTR       24981863//26404942//22608085
chr7:22984381-22984382(-) m6A 3'UTR       24981863//26404942
chr7:22985173-22985174(-) m6A 3'UTR       24981863//26404942//27773535//22608085
chr7:22985243-22985244(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr7:22985276-22985277(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr7:22985281-22985282(-) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr7:22985347-22985348(-) m6A 3'UTR//CDS       24284625//24209618//24981863//28052920//26404942//27773535//22608085
chr7:22985408-22985409(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr7:22985440-22985441(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085
chr7:22985498-22985499(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr7:22985549-22985550(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22608085
chr7:22985587-22985588(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085
chr7:22985608-22985609(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr7:22985634-22985635(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085
chr7:22985676-22985677(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr7:22985753-22985754(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr7:22986622-22986623(-) m6A CDS//intron       24209618//24981863//27773535//22608085
chr7:22986692-22986693(-) m6A CDS//exon//intron       24209618//24981863//27773535//22608085
chr7:22986710-22986711(-) m6A CDS//exon//intron       24209618//24981863//27773535//22608085
chr7:22986755-22986756(-) m6A CDS//exon//intron       24209618//24981863//27773535//22608085
chr7:22986779-22986780(-) m6A CDS//exon//intron       24209618//24981863//27773535//22608085
chr7:22999878-22999879(-) m6A CDS//exon       27773535
chr7:23023617-23023618(-) m6A CDS//exon//intron       27773535
chr7:23023651-23023652(-) m6A CDS//exon//intron       27773535
chr7:23025233-23025234(-) m6A exon//intron       27773535
chr7:23030743-23030744(-) m6A 5'UTR//exon//intron       24209618//25456834//24981863//27371828//27773536
chr7:23053653-23053654(-) m1A 5'UTR//CDS//exon       26863196//26863410
chr7:23053671-23053672(-) m6A 5'UTR//CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate FAM126A
Chromatin K562 cells     -
Cytosol HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART21-5p
Interactor2: FAM126A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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