Basic Information:

  VIRBase ID:  

VHID00413859

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART21-5p:  MIMAT0010130          THOC7:  NM_025075     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART21-5p	THOC7
miRBase Accession/Entrez ID	MIMAT0010130	80145
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	fSAP24//hTREX30//NIF3L1BP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	THOC7	chr3:63838776(-) A-I      intronic chr3:63847713(-) A-I      intronic chr3:63829332(-) A-I      intronic chr3:63836395(-) A-I      intronic chr3:63834952(-) A-I      intronic chr3:63836407(-) A-I      intronic chr3:63836436(-) A-I      intronic chr3:63836439(-) A-I      intronic chr3:63836440(-) A-I      intronic chr3:63824621(-) A-I      intronic chr3:63829021(-) A-I      intronic chr3:63828982(-) A-I      intronic chr3:63828967(-) A-I      intronic chr3:63828916(-) A-I      intronic chr3:63828905(-) A-I      intronic chr3:63828750(-) A-I      intronic chr3:63828680(-) A-I      intronic chr3:63828677(-) A-I      intronic chr3:63828668(-) A-I      intronic chr3:63828534(-) A-I      intronic chr3:63828530(-) A-I      intronic chr3:63828520(-) A-I      intronic chr3:63824822(-) A-I      intronic chr3:63836339(-) A-I      intronic chr3:63824616(-) A-I      intronic chr3:63836348(-) A-I      intronic chr3:63836368(-) A-I      intronic chr3:63836388(-) A-I      intronic chr3:63836391(-) A-I      intronic chr3:63836431(-) A-I      intronic chr3:63836450(-) A-I      intronic chr3:63836469(-) A-I      intronic chr3:63836475(-) A-I      intronic chr3:63836310(-) A-I      intronic chr3:63836278(-) A-I      intronic chr3:63835942(-) A-I      intronic chr3:63834924(-) A-I      intronic chr3:63834915(-) A-I      intronic chr3:63834906(-) A-I      intronic chr3:63834895(-) A-I      intronic chr3:63834891(-) A-I      intronic chr3:63834871(-) A-I      intronic chr3:63833301(-) A-I      intronic chr3:63833294(-) A-I      intronic chr3:63833273(-) A-I      intronic chr3:63838582(-) A-I      intronic chr3:63838605(-) A-I      intronic chr3:63833247(-) A-I      intronic chr3:63833244(-) A-I      intronic chr3:63833221(-) A-I      intronic chr3:63833203(-) A-I      intronic chr3:63833197(-) A-I      intronic chr3:63833196(-) A-I      intronic chr3:63832362(-) A-I      intronic chr3:63832279(-) A-I      intronic chr3:63832259(-) A-I      intronic chr3:63838718(-) A-I      intronic chr3:63838745(-) A-I      intronic chr3:63832216(-) A-I      intronic chr3:63832199(-) A-I      intronic chr3:63832176(-) A-I      intronic chr3:63832111(-) A-I      intronic chr3:63829551(-) A-I      intronic chr3:63829403(-) A-I      intronic chr3:63829347(-) A-I      intronic chr3:63836400(-) A-I      intronic chr3:63846011(-) A-I      intronic chr3:63838770(-) A-I      intronic chr3:63839395(-) A-I      intronic chr3:63826184(-) A-I      intronic chr3:63836509(-) A-I      intronic chr3:63834940(-) A-I      intronic chr3:63836041(-) A-I      intronic chr3:63828997(-) A-I      intronic chr3:63836519(-) A-I      intronic chr3:63838635(-) A-I      intronic chr3:63834820(-) A-I      intronic chr3:63838740(-) A-I      intronic chr3:63836470(-) A-I      intronic chr3:63833291(-) A-I      intronic chr3:63836277(-) A-I      intronic chr3:63828887(-) A-I      intronic chr3:63838744(-) A-I      intronic chr3:63834819(-) A-I      intronic chr3:63833407(-) A-I      intronic chr3:63833409(-) A-I      intronic chr3:63836529(-) A-I      intronic chr3:63835973(-) A-I      intronic chr3:63838664(-) A-I      intronic chr3:63838705(-) A-I      intronic chr3:63835022(-) A-I      intronic chr3:63834900(-) A-I      intronic chr3:63833313(-) A-I      intronic chr3:63838741(-) A-I      intronic chr3:63836017(-) A-I      intronic chr3:63828550(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	THOC7	chr3:63836017(-) A-G intron -    22484847 chr3:63836041(-) A-G intron -    22484847 chr3:63836400(-) A-G intron -    22484847 chr3:63836427(-) A-G intron -    22484847 chr3:63836433(-) A-G intron -    22484847 chr3:63836519(-) A-G intron -    22484847 chr3:63838705(-) A-G intron -    22484847 chr3:63838740(-) A-G intron -    22484847 chr3:63838741(-) A-G intron -    22484847 chr3:63838744(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	THOC7	chr3:63820881-63820882(-) m6A 3'UTR//CDS//exon       24981863 chr3:63821062-63821063(-) m6A 3'UTR//CDS//exon       24981863 chr3:63821983-63821984(-) m6A 3'UTR//CDS//exon       24981863 chr3:63821994-63821995(-) m6A 3'UTR//CDS//exon       24981863 chr3:63824113-63824114(-) m6A 3'UTR//CDS//exon       27773535 chr3:63849228-63849229(-) m6A exon//intron       - chr3:63849358-63849359(-) m6A exon//intron       27773536 chr3:63849387-63849388(-) m6A exon//intron       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	THOC7	Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART21-5p
Interactor2: THOC7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.