Basic Information:

  VIRBase ID:  

VHID00413728

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART21-5p:  MIMAT0010130          SLAIN2:  NM_020846     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART21-5p	SLAIN2
miRBase Accession/Entrez ID	MIMAT0010130	57606
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1458

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLAIN2	chr4:48364643(+) A-I      intronic chr4:48361018(+) A-I      intronic chr4:48361000(+) A-I      intronic chr4:48359834(+) A-I      intronic chr4:48359800(+) A-I      intronic chr4:48415190(+) A-I      intronic chr4:48364575(+) A-I      intronic chr4:48367325(+) A-I      intronic chr4:48387718(+) A-I      intronic chr4:48349396(+) A-I      intronic chr4:48388002(+) A-I      intronic chr4:48420514(+) A-I      intronic chr4:48420482(+) A-I      intronic chr4:48364624(+) A-I      intronic chr4:48364621(+) A-I      intronic chr4:48395118(+) A-I      intronic chr4:48395490(+) A-I      intronic chr4:48367334(+) A-I      intronic chr4:48362566(+) A-I      intronic chr4:48367337(+) A-I      intronic chr4:48364618(+) A-I      intronic chr4:48415124(+) A-I      intronic chr4:48364536(+) A-I      intronic chr4:48364529(+) A-I      intronic chr4:48364513(+) A-I      intronic chr4:48362362(+) A-I      intronic chr4:48362353(+) A-I      intronic chr4:48387714(+) A-I      intronic chr4:48379448(+) A-I      intronic chr4:48379431(+) A-I      intronic chr4:48379336(+) A-I      intronic chr4:48379299(+) A-I      intronic chr4:48379171(+) A-I      intronic chr4:48379148(+) A-I      intronic chr4:48378417(+) A-I      intronic chr4:48378215(+) A-I      intronic chr4:48373773(+) A-I      intronic chr4:48373710(+) A-I      intronic chr4:48395194(+) A-I      intronic chr4:48395170(+) A-I      intronic chr4:48395167(+) A-I      intronic chr4:48395135(+) A-I      intronic chr4:48367340(+) A-I      intronic chr4:48373700(+) A-I      intronic chr4:48367214(+) A-I      intronic chr4:48373295(+) A-I      intronic chr4:48362354(+) A-I      intronic chr4:48379317(+) A-I      intronic chr4:48356715(+) A-I      intronic chr4:48395496(+) A-I      intronic chr4:48362489(+) A-I      intronic chr4:48373799(+) A-I      intronic chr4:48367376(+) A-I      intronic chr4:48367367(+) A-I      intronic chr4:48370195(+) A-I      intronic chr4:48379300(+) A-I      intronic chr4:48387779(+) A-I      intronic chr4:48370205(+) A-I      intronic chr4:48348880(+) A-I      intronic chr4:48387988(+) A-I      intronic chr4:48388004(+) A-I      intronic chr4:48379172(+) A-I      intronic chr4:48367330(+) A-I      intronic chr4:48362488(+) A-I      intronic chr4:48373299(+) A-I      intronic chr4:48350472(+) A-I      intronic chr4:48362432(+) A-I      intronic chr4:48388080(+) A-I      intronic chr4:48367366(+) A-I      intronic chr4:48395157(+) A-I      intronic chr4:48388060(+) A-I      intronic chr4:48348905(+) A-I      intronic chr4:48367413(+) A-I      intronic chr4:48362377(+) A-I      intronic chr4:48360393(+) A-I      intronic chr4:48395491(+) A-I      intronic chr4:48359990(+) A-I      intronic chr4:48356664(+) A-I      intronic chr4:48387799(+) A-I      intronic chr4:48378398(+) A-I      intronic chr4:48379125(+) A-I      intronic chr4:48373768(+) A-I      intronic chr4:48356656(+) A-I      intronic chr4:48364486(+) A-I      intronic chr4:48376007(+) A-I      intronic chr4:48375811(+) A-I      intronic chr4:48378271(+) A-I      intronic chr4:48362461(+) A-I      intronic chr4:48376492(+) A-I      intronic chr4:48379116(+) A-I      intronic chr4:48359755(+) A-I      intronic chr4:48350586(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLAIN2	chr4:48356916(+) C-T intron -    22484847 chr4:48356919(+) T-C intron -    22484847 chr4:48356924(+) C-T intron -    22484847 chr4:48360393(+) A-G intron -    22484847 chr4:48367366(+) A-G intron -    22484847 chr4:48367367(+) A-G intron -    22484847 chr4:48375811(+) A-G intron -    22484847 chr4:48376492(+) A-G intron -    22484847 chr4:48376525(+) A-G intron -    22484847 chr4:48378271(+) A-G intron -    22484847 chr4:48379300(+) A-G intron -    22484847 chr4:48379406(+) A-G intron -    22484847 chr4:48387981(+) A-G intron -    22484847 chr4:48387988(+) A-G intron -    22484847 chr4:48388004(+) A-G intron -    22484847 chr4:48388060(+) A-G intron -    22484847 chr4:48388080(+) A-G intron -    22484847 chr4:48395181(+) A-G intron -    22484847 chr4:48395445(+) A-G intron -    22484847 chr4:48395491(+) A-G intron -    22484847 chr4:48411743(+) G-A intron -    22484847 chr4:48421138(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLAIN2	chr4:48343600-48343601(+) m6A 5'UTR       24209618//25456834//24981863 chr4:48343615-48343616(+) m6A 5'UTR       24209618//25456834//24981863 chr4:48343787-48343788(+) m6A CDS       24209618//25456834//24981863 chr4:48343822-48343823(+) m1A CDS       26863196 chr4:48343842-48343843(+) m6A CDS       24209618//25456834 chr4:48380051-48380052(+) m6A CDS//exon       24981863 chr4:48384675-48384676(+) m6A CDS//intron       24981863 chr4:48384922-48384923(+) m6A 3'UTR//CDS       24981863 chr4:48385667-48385668(+) m6A 3'UTR//CDS       24981863 chr4:48422394-48422395(+) m6A CDS       24284625 chr4:48422439-48422440(+) m6A CDS       24284625//24209618 chr4:48424046-48424047(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr4:48424103-48424104(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr4:48424155-48424156(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr4:48424172-48424173(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:48424186-48424187(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr4:48424235-48424236(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr4:48424253-48424254(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr4:48424342-48424343(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLAIN2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART21-5p
Interactor2: SLAIN2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.