Basic Information:

  VIRBase ID:  

VHID00413077

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART21-5p:  MIMAT0010130          ZNF225:  NM_001321685     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART21-5p	ZNF225
miRBase Accession/Entrez ID	MIMAT0010130	7768
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF225	chr19:44624295(+) A-I      intronic chr19:44620119(+) A-I      intronic chr19:44625179(+) A-I      intronic chr19:44625176(+) A-I      intronic chr19:44625143(+) A-I      intronic chr19:44621943(+) A-I      intronic chr19:44621995(+) A-I      intronic chr19:44621994(+) A-I      intronic chr19:44622001(+) A-I      intronic chr19:44622052(+) A-I      intronic chr19:44622061(+) A-I      intronic chr19:44622068(+) A-I      intronic chr19:44624249(+) A-I      intronic chr19:44624255(+) A-I      intronic chr19:44620058(+) A-I      intronic chr19:44624259(+) A-I      intronic chr19:44625105(+) A-I      intronic chr19:44625114(+) A-I      intronic chr19:44621957(+) A-I      intronic chr19:44625233(+) A-I      intronic chr19:44625189(+) A-I      intronic chr19:44620140(+) A-I      intronic chr19:44620141(+) A-I      intronic chr19:44620236(+) A-I      intronic chr19:44624185(+) A-I      intronic chr19:44624236(+) A-I      intronic chr19:44620070(+) A-I      intronic chr19:44624103(+) A-I      intronic chr19:44625069(+) A-I      intronic chr19:44620189(+) A-I      intronic chr19:44625257(+) A-I      intronic chr19:44624161(+) A-I      intronic chr19:44620144(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF225	chr19:44634289(+) A-I intron -    15342557   //15258596 chr19:44634318(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634370(+) A-I intron -    15342557   //22028664 chr19:44634373(+) A-I intron -    15342557   //22028664 chr19:44634401(+) A-I intron -    15342557   //22028664 chr19:44634405(+) A-I intron -    15342557   //22028664 chr19:44634409(+) A-I intron -    15342557   //22028664 chr19:44634441(+) A-I intron -    15342557   //22028664 chr19:44634445(+) A-I intron -    15342557   //22028664 chr19:44634452(+) A-I intron -    15342557   //22028664 chr19:44634454(+) A-I intron -    15342557   //22028664 chr19:44634477(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634534(+) A-I intron -    15342557   //22028664 chr19:44634580(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634590(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634596(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634597(+) A-I intron -    15342557   //15258596   //22028664 chr19:44634632(+) A-I intron -    15342557   //22028664 chr19:44634640(+) A-I intron -    15342557   //22028664 chr19:44634654(+) A-I intron -    15342557   //22028664 chr19:44634663(+) A-I intron -    15342557   //22028664 chr19:44634664(+) A-I intron -    15342557   //22028664 chr19:44634668(+) A-I intron -    15342557   //22028664 chr19:44634674(+) A-I intron -    15342557   //22028664 chr19:44634679(+) A-I intron -    15342557   //22028664 chr19:44634689(+) A-I intron -    15342557   //22028664 chr19:44634694(+) A-I intron -    15342557   //22028664 chr19:44634699(+) A-I intron -    15342557   //22028664 chr19:44634700(+) A-I intron -    15342557   //22028664 chr19:44634701(+) A-I intron -    15342557   //22028664 chr19:44634704(+) A-I intron -    15342557   //22028664 chr19:44634728(+) A-I intron -    15342557   //22028664 chr19:44634730(+) A-I intron -    15342557   //22028664 chr19:44634736(+) A-I intron -    15342557   //22028664 chr19:44634740(+) A-I intron -    15342557   //22028664 chr19:44634775(+) A-I intron -    15342557   //22028664 chr19:44634779(+) A-I intron -    15342557   //22028664 chr19:44634809(+) A-I intron -    15342557   //22028664 chr19:44634824(+) A-I intron -    15342557   //22028664

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF225	chr19:44622401-44622402(+) m6A CDS       24981863 chr19:44622417-44622418(+) m6A CDS       24981863 chr19:44622443-44622444(+) m6A CDS       - chr19:44635046-44635047(+) m6A 3'UTR//CDS       - chr19:44635073-44635074(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635081-44635082(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635113-44635114(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635125-44635126(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635144-44635145(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635177-44635178(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635198-44635199(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635204-44635205(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635372-44635373(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635456-44635457(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635504-44635505(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635540-44635541(+) m6A 3'UTR//CDS       22608085 chr19:44635708-44635709(+) m6A 3'UTR//CDS       22608085 chr19:44635860-44635861(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44635933-44635934(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr19:44635958-44635959(+) m6A 3'UTR//CDS       24209618//25456834//24981863//27773535//22608085 chr19:44636128-44636129(+) m6A 3'UTR//CDS       25456834//24981863//22608085 chr19:44636212-44636213(+) m6A 3'UTR//CDS       24981863//22608085 chr19:44636296-44636297(+) m6A 3'UTR//CDS       22608085 chr19:44636464-44636465(+) m6A 3'UTR//CDS       24209618//24981863//22608085 chr19:44636530-44636531(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr19:44636698-44636699(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:44636716-44636717(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr19:44636733-44636734(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:44636772-44636773(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:44636784-44636785(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:44636801-44636802(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr19:44636817-44636818(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZNF225	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART21-5p
Interactor2: ZNF225

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.