Basic Information:

  VIRBase ID:  

VHID00412889

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART21-5p:  MIMAT0010130          MTRR:  NR_157177     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART21-5p	MTRR
miRBase Accession/Entrez ID	MIMAT0010130	4552
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	cblE//MSR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MTRR	chr5:7878292-7878293(+) m6A 3'UTR//CDS       24981863 chr5:7878322-7878323(+) m6A 3'UTR//CDS       24981863 chr5:7885910-7885911(+) Am 3'UTR//CDS//exon       - chr5:7890518-7890519(+) m6A exon//intron       - chr5:7891485-7891486(+) m6A 3'UTR//CDS//exon       - chr5:7891497-7891498(+) m6A 3'UTR//CDS//exon       - chr5:7891509-7891510(+) m6A 3'UTR//CDS//exon       - chr5:7892979-7892980(+) m6A 3'UTR//CDS//exon       - chr5:7893000-7893001(+) m6A 3'UTR//CDS//exon       - chr5:7893088-7893089(+) m6A exon//intron       - chr5:7900101-7900102(+) m6A 3'UTR//CDS//exon       22608085 chr5:7900117-7900118(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085 chr5:7900172-7900173(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr5:7900243-7900244(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr5:7900290-7900291(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr5:7900329-7900330(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr5:7900470-7900471(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr5:7900481-7900482(+) m6A 3'UTR//exon       24284625//24209618//24981863//22575960//22608085 chr5:7900520-7900521(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr5:7901089-7901090(+) m6A 3'UTR//intron       27773535 chr5:7901094-7901095(+) m6A 3'UTR//intron       27773535 chr5:7901168-7901169(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MTRR	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART21-5p
Interactor2: MTRR

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.