Basic Information:

  VIRBase ID:  

VHID00410399

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART4-3p:  MIMAT0009204          CPSF7:  NM_024811     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART4-3p	CPSF7
miRBase Accession/Entrez ID	MIMAT0009204	79869
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CFIm59

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CPSF7	chr11:61181050(-) A-I      intronic chr11:61180845(-) A-I      intronic chr11:61176613(-) A-I      intronic chr11:61180981(-) A-I      intronic chr11:61177280(-) A-I      intronic chr11:61180993(-) A-I      intronic chr11:61176408(-) A-I      intronic chr11:61182464(-) A-I      intronic chr11:61180911(-) A-I      intronic chr11:61179890(-) A-I      intronic chr11:61177385(-) A-I      intronic chr11:61179886(-) A-I      intronic chr11:61179796(-) A-I      intronic chr11:61177474(-) A-I      intronic chr11:61177758(-) A-I      intronic chr11:61177726(-) A-I      intronic chr11:61177662(-) A-I      intronic chr11:61177630(-) A-I      intronic chr11:61181857(-) A-I      intronic chr11:61177554(-) A-I      intronic chr11:61177510(-) A-I      intronic chr11:61177502(-) A-I      intronic chr11:61177380(-) A-I      intronic chr11:61181714(-) A-I      intronic chr11:61181871(-) A-I      intronic chr11:61181804(-) A-I      intronic chr11:61177226(-) A-I      intronic chr11:61177204(-) A-I      intronic chr11:61176860(-) A-I      intronic chr11:61176844(-) A-I      intronic chr11:61176822(-) A-I      intronic chr11:61176819(-) A-I      intronic chr11:61176781(-) A-I      intronic chr11:61176530(-) A-I      intronic chr11:61176496(-) A-I      intronic chr11:61176429(-) A-I      intronic chr11:61177203(-) A-I      intronic chr11:61175805(-) A-I      intronic chr11:61175736(-) A-I      intronic chr11:61175696(-) A-I      intronic chr11:61175685(-) A-I      intronic chr11:61175657(-) A-I      intronic chr11:61175625(-) A-I      intronic chr11:61175614(-) A-I      intronic chr11:61174515(-) A-I      intronic chr11:61174510(-) A-I      intronic chr11:61174491(-) A-I      intronic chr11:61174428(-) A-I      intronic chr11:61181079(-) A-I      intronic chr11:61180874(-) A-I      intronic chr11:61189820(-) A-I      intronic chr11:61182586(-) A-I      intronic chr11:61192089(-) A-I      intronic chr11:61177788(-) A-I      intronic chr11:61195908(-) A-I      intronic chr11:61181852(-) A-I      intronic chr11:61176549(-) A-I      intronic chr11:61179956(-) A-I      intronic chr11:61181802(-) A-I      intronic chr11:61177725(-) A-I      intronic chr11:61176566(-) A-I      intronic chr11:61177667(-) A-I      intronic chr11:61177498(-) A-I      intronic chr11:61180596(-) A-I      intronic chr11:61190346(-) A-I      intronic chr11:61190360(-) A-I      intronic chr11:61181767(-) A-I      intronic chr11:61195793(-) A-I      intronic chr11:61181021(-) A-I      intronic chr11:61177497(-) A-I      intronic chr11:61189963(-) A-I      intronic chr11:61181796(-) A-I      intronic chr11:61180955(-) A-I      intronic chr11:61175667(-) A-I      intronic chr11:61181750(-) A-I      intronic chr11:61177297(-) A-I      intronic chr11:61194388(-) A-I      intronic chr11:61181870(-) A-I      intronic chr11:61194341(-) A-I      intronic chr11:61181808(-) A-I      intronic chr11:61181861(-) A-I      intronic chr11:61181769(-) A-I      intronic chr11:61181789(-) A-I      intronic chr11:61181817(-) A-I      intronic chr11:61194332(-) A-I      intronic chr11:61194330(-) A-I      intronic chr11:61194318(-) A-I      intronic chr11:61190861(-) A-I      intronic chr11:61190818(-) A-I      intronic chr11:61181887(-) A-I      intronic chr11:61177734(-) A-I      intronic chr11:61190782(-) A-I      intronic chr11:61177307(-) A-I      intronic chr11:61190769(-) A-I      intronic chr11:61190070(-) A-I      intronic chr11:61189992(-) A-I      intronic chr11:61189954(-) A-I      intronic chr11:61189878(-) A-I      intronic chr11:61182492(-) A-I      intronic chr11:61181104(-) A-I      intronic chr11:61181087(-) A-I      intronic chr11:61181041(-) A-I      intronic chr11:61181794(-) A-I      intronic chr11:61181025(-) A-I      intronic chr11:61180847(-) A-I      intronic chr11:61181775(-) A-I      intronic chr11:61180844(-) A-I      intronic chr11:61180688(-) A-I      intronic chr11:61180676(-) A-I      intronic chr11:61181805(-) A-I      intronic chr11:61190872(-) A-I      intronic chr11:61180634(-) A-I      intronic chr11:61180616(-) A-I      intronic chr11:61181798(-) A-I      intronic chr11:61180615(-) A-I      intronic chr11:61181811(-) A-I      intronic chr11:61180656(-) A-I      intronic chr11:61181727(-) A-I      intronic chr11:61180573(-) A-I      intronic chr11:61180033(-) A-I      intronic chr11:61177263(-) A-I      intronic chr11:61180012(-) A-I      intronic chr11:61179982(-) A-I      intronic chr11:61177737(-) A-I      intronic chr11:61181800(-) A-I      intronic chr11:61179936(-) A-I      intronic chr11:61181659(-) A-I      intronic chr11:61179933(-) A-I      intronic chr11:61179894(-) A-I      intronic chr11:61182598(-) A-I      intronic chr11:61182553(-) A-I      intronic chr11:61190061(-) A-I      intronic chr11:61176603(-) A-I      intronic chr11:61177698(-) A-I      intronic chr11:61177835(-) A-I      intronic chr11:61192062(-) A-I      intronic chr11:61174300(-) A-I      intronic chr11:61177691(-) A-I      intronic chr11:61176497(-) A-I      intronic chr11:61176434(-) A-I      intronic chr11:61182663(-) A-I      intronic chr11:61174378(-) A-I      intronic chr11:61177721(-) A-I      intronic chr11:61179818(-) A-I      intronic chr11:61195891(-) A-I      intronic chr11:61180861(-) A-I      intronic chr11:61177379(-) A-I      intronic chr11:61179838(-) A-I      intronic chr11:61190530(-) A-I      intronic chr11:61177266(-) A-I      intronic chr11:61177466(-) A-I      intronic chr11:61190074(-) A-I      intronic chr11:61180940(-) A-I      intronic chr11:61177752(-) A-I      intronic chr11:61194456(-) A-I      intronic chr11:61180669(-) A-I      intronic chr11:61190444(-) A-I      intronic chr11:61176490(-) A-I      intronic chr11:61177390(-) A-I      intronic chr11:61177434(-) A-I      intronic chr11:61177694(-) A-I      intronic chr11:61180519(-) A-I      intronic chr11:61181016(-) A-I      intronic chr11:61180034(-) A-I      intronic chr11:61182588(-) A-I      intronic chr11:61176386(-) A-I      intronic chr11:61176671(-) A-I      intronic chr11:61194417(-) A-I      intronic chr11:61177398(-) A-I      intronic chr11:61177261(-) A-I      intronic chr11:61194942(-) A-I      intronic chr11:61180959(-) A-I      intronic chr11:61181020(-) A-I      intronic chr11:61195001(-) A-I      intronic chr11:61177197(-) A-I      intronic chr11:61181797(-) A-I      intronic chr11:61175693(-) A-I      intronic chr11:61179926(-) A-I      intronic chr11:61177727(-) A-I      intronic chr11:61180562(-) A-I      intronic chr11:61177781(-) A-I      intronic chr11:61176446(-) A-I      intronic chr11:61175846(-) A-I      intronic chr11:61177739(-) A-I      intronic chr11:61174509(-) A-I      intronic chr11:61174406(-) A-I      intronic chr11:61174388(-) A-I      intronic chr11:61177756(-) A-I      intronic chr11:61173022(-) A-I      intronic chr11:61176433(-) A-I      intronic chr11:61177436(-) A-I      intronic chr11:61195948(-) A-I      intronic chr11:61190536(-) A-I      intronic chr11:61177406(-) A-I      intronic chr11:61176595(-) A-I      intronic chr11:61195783(-) A-I      intronic chr11:61177345(-) A-I      intronic chr11:61176880(-) A-I      intronic chr11:61180028(-) A-I      intronic chr11:61194243(-) A-I      intronic chr11:61181027(-) A-I      intronic chr11:61177730(-) A-I      intronic chr11:61177333(-) A-I      intronic chr11:61177823(-) A-I      intronic chr11:61176416(-) A-I      intronic chr11:61180920(-) A-I      intronic chr11:61175714(-) A-I      intronic chr11:61192183(-) A-I      intronic chr11:61190402(-) A-I      intronic chr11:61190537(-) A-I      intronic chr11:61190531(-) A-I      intronic chr11:61180643(-) A-I      intronic chr11:61177323(-) A-I      intronic chr11:61177283(-) A-I      intronic chr11:61180860(-) A-I      intronic chr11:61189951(-) A-I      intronic chr11:61177736(-) A-I      intronic chr11:61182458(-) A-I      intronic chr11:61176544(-) A-I      intronic chr11:61177812(-) A-I      intronic chr11:61182537(-) A-I      intronic chr11:61177831(-) A-I      intronic chr11:61177807(-) A-I      intronic chr11:61180937(-) A-I      intronic chr11:61181040(-) A-I      intronic chr11:61177191(-) A-I      intronic chr11:61180991(-) A-I      intronic chr11:61190433(-) A-I      intronic chr11:61179851(-) A-I      intronic chr11:61180672(-) A-I      intronic chr11:61181694(-) A-I      intronic chr11:61194462(-) A-I      intronic chr11:61177359(-) A-I      intronic chr11:61180461(-) A-I      intronic chr11:61190493(-) A-I      intronic chr11:61175858(-) A-I      intronic chr11:61194378(-) A-I      intronic chr11:61175860(-) A-I      intronic chr11:61174245(-) A-I      intronic chr11:61180859(-) A-I      intronic chr11:61182648(-) A-I      intronic chr11:61195003(-) A-I      intronic chr11:61180995(-) A-I      intronic chr11:61180899(-) A-I      intronic chr11:61173307(-) A-I      intronic chr11:61180459(-) A-I      intronic chr11:61181893(-) A-I      intronic chr11:61190938(-) A-I      intronic chr11:61180886(-) A-I      intronic chr11:61189982(-) A-I      intronic chr11:61177491(-) A-I      intronic chr11:61175738(-) A-I      intronic chr11:61176459(-) A-I      intronic chr11:61194653(-) A-I      intronic chr11:61192017(-) A-I      intronic chr11:61180620(-) A-I      intronic chr11:61180990(-) A-I      intronic chr11:61174414(-) A-I      intronic chr11:61194424(-) A-I      intronic chr11:61194416(-) A-I      intronic chr11:61190387(-) A-I      intronic chr11:61177254(-) A-I      intronic chr11:61177784(-) A-I      intronic chr11:61194968(-) A-I      intronic chr11:61189993(-) A-I      intronic chr11:61177189(-) A-I      intronic chr11:61180442(-) A-I      intronic chr11:61179900(-) A-I      intronic chr11:61181799(-) A-I      intronic chr11:61190736(-) A-I      intronic chr11:61177760(-) A-I      intronic chr11:61174228(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CPSF7	chr11:61182586(-) A-I intron -    15258596 chr11:61182588(-) A-I intron -    15258596 chr11:61182648(-) A-I intron -    15258596 chr11:61182663(-) A-I intron -    15258596 chr11:61177831(-) A-I intron -    21960545   //22327324 chr11:61180596(-) A-I intron -    22327324 chr11:61180656(-) A-I intron -    22327324 chr11:61177307(-) A-I intron -    22028664 chr11:61177323(-) A-I intron -    22028664 chr11:61177345(-) A-I intron -    22028664 chr11:61177379(-) A-I intron -    22028664 chr11:61177385(-) A-I intron -    22028664 chr11:61177390(-) A-I intron -    22028664 chr11:61177398(-) A-I intron -    22028664 chr11:61175858(-) A-I intron -    21960545 chr11:61177197(-) A-G intron -    22484847 chr11:61177406(-) A-G intron -    22484847 chr11:61177434(-) A-G intron -    22484847 chr11:61177667(-) A-G intron -    22484847 chr11:61177698(-) A-G intron -    22484847 chr11:61177721(-) A-G intron -    22484847 chr11:61177739(-) A-G intron -    22484847 chr11:61177823(-) A-G intron -    22484847 chr11:61177831(-) A-G intron -    22484847 chr11:61179926(-) A-G intron -    22484847 chr11:61179956(-) A-G intron -    22484847 chr11:61180519(-) A-G intron -    22484847 chr11:61180672(-) A-G intron -    22484847 chr11:61181893(-) A-G intron -    22484847 chr11:61182458(-) A-G intron -    22484847 chr11:61189993(-) A-G intron -    22484847 chr11:61190360(-) A-G intron -    22484847 chr11:61190938(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CPSF7	chr11:61170527-61170528(-) m6A 3'UTR       24284625//24209618//25456834//27773535 chr11:61170593-61170594(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:61170682-61170683(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170687-61170688(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170697-61170698(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170721-61170722(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170738-61170739(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170752-61170753(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61170943-61170944(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:61170964-61170965(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:61170984-61170985(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr11:61171500-61171501(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr11:61171537-61171538(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr11:61171626-61171627(-) m6A 3'UTR       24284625 chr11:61171635-61171636(-) m6A 3'UTR       24284625 chr11:61171698-61171699(-) m6A 3'UTR       24284625 chr11:61171921-61171922(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr11:61171932-61171933(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr11:61171959-61171960(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:61171967-61171968(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:61172018-61172019(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61172055-61172056(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61172073-61172074(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61172116-61172117(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61172142-61172143(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:61173455-61173456(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:61173517-61173518(-) m6A exon//intron       25456834//27773535//27371828 chr11:61178427-61178428(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22575960 chr11:61178447-61178448(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22575960 chr11:61178463-61178464(-) m6A CDS//exon       24209618//24981863//26404942//27773535//22575960 chr11:61178570-61178571(-) m6A CDS//exon       27773535//22575960 chr11:61183190-61183191(-) m6A CDS//exon       27773535 chr11:61183569-61183570(-) m6A exon//intron       24284625//24981863//27773535 chr11:61183921-61183922(-) m6A 3'UTR//CDS//exon       24284625//27773535 chr11:61188935-61188936(-) m6A CDS//exon//intron       24981863//27773535//27371828 chr11:61188984-61188985(-) m6A CDS//exon//intron       24981863//27773535//27371828 chr11:61196690-61196691(-) m6A CDS//exon       24284625//24981863//27773535 chr11:61196730-61196731(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535 chr11:61197412-61197413(-) m6A 5'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CPSF7	Chromatin HCC cell line (HepG2)|K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm HCC cell line (HepG2)|K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART4-3p
Interactor2: CPSF7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).