Basic Information:

  VIRBase ID:  

VHID00407613

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-5p:  MIMAT0004836          ZNF585B:  NM_152279     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-5p	ZNF585B
miRBase Accession/Entrez ID	MIMAT0004836	92285
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SZFP41//Zfp27

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZNF585B	chr19:37700196(-) A-I      intronic chr19:37694565(-) A-I      intronic chr19:37693010(-) A-I      intronic chr19:37693026(-) A-I      intronic chr19:37700218(-) A-I      intronic chr19:37673313(-) A-I      3'UTR chr19:37700183(-) A-I      intronic chr19:37700221(-) A-I      intronic chr19:37700175(-) A-I      intronic chr19:37694598(-) A-I      intronic chr19:37693023(-) A-I      intronic chr19:37694568(-) A-I      intronic chr19:37690315(-) A-I      intronic chr19:37690365(-) A-I      intronic chr19:37690370(-) A-I      intronic chr19:37690423(-) A-I      intronic chr19:37691317(-) A-I      intronic chr19:37691369(-) A-I      intronic chr19:37691954(-) A-I      intronic chr19:37693014(-) A-I      intronic chr19:37693020(-) A-I      intronic chr19:37693029(-) A-I      intronic chr19:37693045(-) A-I      intronic chr19:37693069(-) A-I      intronic chr19:37693103(-) A-I      intronic chr19:37693673(-) A-I      intronic chr19:37693708(-) A-I      intronic chr19:37694330(-) A-I      intronic chr19:37694338(-) A-I      intronic chr19:37694375(-) A-I      intronic chr19:37694591(-) A-I      intronic chr19:37694603(-) A-I      intronic chr19:37694668(-) A-I      intronic chr19:37695734(-) A-I      intronic chr19:37695787(-) A-I      intronic chr19:37695858(-) A-I      intronic chr19:37695863(-) A-I      intronic chr19:37695877(-) A-I      intronic chr19:37698986(-) A-I      intronic chr19:37698996(-) A-I      intronic chr19:37699093(-) A-I      intronic chr19:37699702(-) A-I      intronic chr19:37699722(-) A-I      intronic chr19:37700112(-) A-I      intronic chr19:37700223(-) A-I      intronic chr19:37700782(-) A-I      intronic chr19:37700789(-) A-I      intronic chr19:37700792(-) A-I      intronic chr19:37700794(-) A-I      intronic chr19:37700812(-) A-I      intronic chr19:37703323(-) A-I      intronic chr19:37707908(-) A-I      intronic chr19:37700822(-) A-I      intronic chr19:37689592(-) A-I      intronic chr19:37681530(-) A-I      intronic chr19:37681646(-) A-I      intronic chr19:37681661(-) A-I      intronic chr19:37682328(-) A-I      intronic chr19:37682408(-) A-I      intronic chr19:37682410(-) A-I      intronic chr19:37682463(-) A-I      intronic chr19:37682762(-) A-I      intronic chr19:37682768(-) A-I      intronic chr19:37682888(-) A-I      intronic chr19:37689103(-) A-I      intronic chr19:37689146(-) A-I      intronic chr19:37689243(-) A-I      intronic chr19:37689253(-) A-I      intronic chr19:37689275(-) A-I      intronic chr19:37689281(-) A-I      intronic chr19:37689290(-) A-I      intronic chr19:37689298(-) A-I      intronic chr19:37689341(-) A-I      intronic chr19:37689346(-) A-I      intronic chr19:37689416(-) A-I      intronic chr19:37689472(-) A-I      intronic chr19:37689475(-) A-I      intronic chr19:37689526(-) A-I      intronic chr19:37689538(-) A-I      intronic chr19:37689556(-) A-I      intronic chr19:37689591(-) A-I      intronic chr19:37690184(-) A-I      intronic chr19:37690207(-) A-I      intronic chr19:37690241(-) A-I      intronic chr19:37690246(-) A-I      intronic chr19:37690249(-) A-I      intronic chr19:37681200(-) A-I      5'UTR chr19:37681321(-) A-I      5'UTR chr19:37690172(-) A-I      intronic chr19:37705906(-) A-I      intronic chr19:37693180(-) A-I      intronic chr19:37685312(-) A-I      intronic chr19:37689329(-) A-I      intronic chr19:37696819(-) A-I      intronic chr19:37689136(-) A-I      intronic chr19:37689302(-) A-I      intronic chr19:37691340(-) A-I      intronic chr19:37681650(-) A-I      intronic chr19:37694300(-) A-I      intronic chr19:37684560(-) A-I      intronic chr19:37685353(-) A-I      intronic chr19:37690318(-) A-I      intronic chr19:37693108(-) A-I      intronic chr19:37699782(-) A-I      intronic chr19:37690327(-) A-I      intronic chr19:37689446(-) A-I      intronic chr19:37694593(-) A-I      intronic chr19:37707727(-) A-I      intronic chr19:37696900(-) A-I      intronic chr19:37694729(-) A-I      intronic chr19:37699888(-) A-I      intronic chr19:37682771(-) A-I      intronic chr19:37699847(-) A-I      intronic chr19:37690208(-) A-I      intronic chr19:37689202(-) A-I      intronic chr19:37696834(-) A-I      intronic chr19:37695822(-) A-I      intronic chr19:37699054(-) A-I      intronic chr19:37690211(-) A-I      intronic chr19:37696724(-) A-I      intronic chr19:37699811(-) A-I      intronic chr19:37694299(-) A-I      intronic chr19:37689268(-) A-I      intronic chr19:37679276(-) A-I      intronic chr19:37699053(-) A-I      intronic chr19:37699832(-) A-I      intronic chr19:37695809(-) A-I      intronic chr19:37700890(-) A-I      intronic chr19:37696825(-) A-I      intronic chr19:37689128(-) A-I      intronic chr19:37699689(-) A-I      intronic chr19:37681220(-) A-I      5'UTR chr19:37699013(-) A-I      intronic chr19:37682356(-) A-I      intronic chr19:37693790(-) A-I      intronic chr19:37699083(-) A-I      intronic chr19:37681739(-) A-I      intronic chr19:37694628(-) A-I      intronic chr19:37694797(-) A-I      intronic chr19:37699676(-) A-I      intronic chr19:37681721(-) A-I      intronic chr19:37693172(-) A-I      intronic chr19:37700889(-) A-I      intronic chr19:37689238(-) A-I      intronic chr19:37681285(-) A-I      5'UTR chr19:37707420(-) A-I      intronic chr19:37707356(-) A-I      intronic chr19:37700185(-) A-I      intronic chr19:37689220(-) A-I      intronic chr19:37692949(-) A-I      intronic chr19:37707299(-) A-I      intronic chr19:37682398(-) A-I      intronic chr19:37707282(-) A-I      intronic chr19:37695828(-) A-I      intronic chr19:37682444(-) A-I      intronic chr19:37694282(-) A-I      intronic chr19:37700182(-) A-I      intronic chr19:37699145(-) A-I      intronic chr19:37707316(-) A-I      intronic chr19:37695568(-) A-I      intronic chr19:37696943(-) A-I      intronic chr19:37707724(-) A-I      intronic chr19:37682354(-) A-I      intronic chr19:37695513(-) A-I      intronic chr19:37700184(-) A-I      intronic chr19:37700138(-) A-I      intronic chr19:37697191(-) A-I      intronic chr19:37681221(-) A-I      5'UTR chr19:37695786(-) A-I      intronic chr19:37693098(-) A-I      intronic chr19:37695641(-) A-I      intronic chr19:37693142(-) A-I      intronic chr19:37700144(-) A-I      intronic chr19:37682832(-) A-I      intronic chr19:37682443(-) A-I      intronic chr19:37681215(-) A-I      5'UTR chr19:37690194(-) A-I      intronic chr19:37690381(-) A-I      intronic chr19:37693054(-) A-I      intronic chr19:37699003(-) A-I      intronic chr19:37690183(-) A-I      intronic chr19:37682468(-) A-I      intronic chr19:37690237(-) A-I      intronic chr19:37681253(-) A-I      5'UTR chr19:37681259(-) A-I      5'UTR chr19:37690178(-) A-I      intronic chr19:37707360(-) A-I      intronic chr19:37700074(-) A-I      intronic chr19:37707856(-) A-I      intronic chr19:37698980(-) A-I      intronic chr19:37707450(-) A-I      intronic chr19:37689230(-) A-I      intronic chr19:37695929(-) A-I      intronic chr19:37695823(-) A-I      intronic chr19:37684435(-) A-I      intronic chr19:37699021(-) A-I      intronic chr19:37700201(-) A-I      intronic chr19:37695555(-) A-I      intronic chr19:37694356(-) A-I      intronic chr19:37681312(-) A-I      5'UTR chr19:37699756(-) A-I      intronic chr19:37699076(-) A-I      intronic chr19:37699812(-) A-I      intronic chr19:37690412(-) A-I      intronic chr19:37693776(-) A-I      intronic chr19:37685393(-) A-I      intronic chr19:37695832(-) A-I      intronic chr19:37707869(-) A-I      intronic chr19:37695853(-) A-I      intronic chr19:37700145(-) A-I      intronic chr19:37693796(-) A-I      intronic chr19:37690261(-) A-I      intronic chr19:37694627(-) A-I      intronic chr19:37700103(-) A-I      intronic chr19:37690332(-) A-I      intronic chr19:37682870(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ZNF585B	chr19:37681215(-) A-I intron -    15342557   //15258596 chr19:37681216(-) A-I intron -    15342557   //15258596 chr19:37681220(-) A-I intron -    15342557   //15258596 chr19:37681221(-) A-I intron -    15342557   //15258596 chr19:37681253(-) A-I intron -    15342557 chr19:37681259(-) A-I intron -    15342557 chr19:37681272(-) A-I intron -    15342557 chr19:37681285(-) A-I intron -    15342557 chr19:37681312(-) A-I intron -    15342557 chr19:37684560(-) A-G intron -    22484847 chr19:37689128(-) A-G intron -    22484847 chr19:37690208(-) A-G intron -    22484847 chr19:37690237(-) A-G intron -    22484847 chr19:37694299(-) A-G intron -    22484847 chr19:37699013(-) A-G intron -    22484847 chr19:37699021(-) A-G intron -    22484847 chr19:37700177(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF585B	chr19:37675898-37675899(-) m6A 3'UTR       22608085 chr19:37675928-37675929(-) m6A 3'UTR       22608085 chr19:37675959-37675960(-) m6A 3'UTR       22608085 chr19:37676109-37676110(-) m6A 3'UTR       22608085 chr19:37676122-37676123(-) m6A 3'UTR       22608085 chr19:37676210-37676211(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37676226-37676227(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37676233-37676234(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37676794-37676795(-) m6A 3'UTR//CDS       22608085 chr19:37676915-37676916(-) m6A 3'UTR//CDS       22608085 chr19:37676979-37676980(-) m6A 3'UTR//CDS       22608085 chr19:37677130-37677131(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37677190-37677191(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37677298-37677299(-) m6A 3'UTR//CDS       22608085 chr19:37677550-37677551(-) m6A 3'UTR//CDS       22608085 chr19:37677591-37677592(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37677718-37677719(-) m6A 3'UTR//CDS       24981863//22608085 chr19:37677802-37677803(-) m6A CDS       24981863//22608085 chr19:37677903-37677904(-) m6A CDS//intron       24981863//22608085 chr19:37677970-37677971(-) m6A CDS//intron       24981863//22608085 chr19:37678096-37678097(-) m6A CDS       22608085 chr19:37678130-37678131(-) m6A CDS       22608085 chr19:37701386-37701387(-) m6A 5'UTR//intron       24981863 chr19:37708620-37708621(-) m6A exon       22608085 chr19:37708658-37708659(-) m6A exon       22608085 chr19:37708665-37708666(-) m6A exon       22608085 chr19:37708768-37708769(-) m6A exon       25456834//22608085 chr19:37708828-37708829(-) m6A exon       25456834//22608085 chr19:37708876-37708877(-) m6A exon       25456834//22608085 chr19:37708909-37708910(-) m6A exon       - chr19:37708927-37708928(-) m6A exon       - chr19:37708955-37708956(-) m6A exon       - chr19:37708977-37708978(-) m6A exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-5p	Exosome B cell line (Raji)     21505438
	ZNF585B	Cytosol HCC cell line (HepG2)     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-5p
Interactor2: ZNF585B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.