Basic Information:

  VIRBase ID:  

VHID00406130

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-5p:  MIMAT0004836          CDC23:  NM_004661     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-5p	CDC23
miRBase Accession/Entrez ID	MIMAT0004836	8697
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ANAPC8//APC8//CUT23

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC23	chr5:137530548(-) A-I      intronic chr5:137530539(-) A-I      intronic chr5:137529584(-) A-I      intronic chr5:137529223(-) A-I      intronic chr5:137529222(-) A-I      intronic chr5:137529209(-) A-I      intronic chr5:137529119(-) A-I      intronic chr5:137529093(-) A-I      intronic chr5:137526974(-) A-I      intronic chr5:137526949(-) A-I      intronic chr5:137526270(-) A-I      intronic chr5:137526208(-) A-I      intronic chr5:137529252(-) A-I      intronic chr5:137529258(-) A-I      intronic chr5:137529284(-) A-I      intronic chr5:137546139(-) A-I      intronic chr5:137548286(-) A-I      intronic chr5:137547252(-) A-I      intronic chr5:137546158(-) A-I      intronic chr5:137547179(-) A-I      intronic chr5:137546103(-) A-I      intronic chr5:137546093(-) A-I      intronic chr5:137545989(-) A-I      intronic chr5:137546048(-) A-I      intronic chr5:137545482(-) A-I      intronic chr5:137545413(-) A-I      intronic chr5:137545391(-) A-I      intronic chr5:137545311(-) A-I      intronic chr5:137545263(-) A-I      intronic chr5:137545055(-) A-I      intronic chr5:137545054(-) A-I      intronic chr5:137545041(-) A-I      intronic chr5:137545008(-) A-I      intronic chr5:137545005(-) A-I      intronic chr5:137544520(-) A-I      intronic chr5:137543807(-) A-I      intronic chr5:137542824(-) A-I      intronic chr5:137540142(-) A-I      intronic chr5:137540046(-) A-I      intronic chr5:137540037(-) A-I      intronic chr5:137539968(-) A-I      intronic chr5:137539950(-) A-I      intronic chr5:137539949(-) A-I      intronic chr5:137538069(-) A-I      intronic chr5:137538058(-) A-I      intronic chr5:137538049(-) A-I      intronic chr5:137536400(-) A-I      intronic chr5:137535990(-) A-I      intronic chr5:137535927(-) A-I      intronic chr5:137535917(-) A-I      intronic chr5:137532911(-) A-I      intronic chr5:137532908(-) A-I      intronic chr5:137532883(-) A-I      intronic chr5:137532873(-) A-I      intronic chr5:137532402(-) A-I      intronic chr5:137530593(-) A-I      intronic chr5:137530590(-) A-I      intronic chr5:137530588(-) A-I      intronic chr5:137530575(-) A-I      intronic chr5:137530555(-) A-I      intronic chr5:137540036(-) A-I      intronic chr5:137532312(-) A-I      intronic chr5:137540658(-) A-I      intronic chr5:137538155(-) A-I      intronic chr5:137545091(-) A-I      intronic chr5:137546182(-) A-I      intronic chr5:137543501(-) A-I      intronic chr5:137532156(-) A-I      intronic chr5:137543828(-) A-I      intronic chr5:137529040(-) A-I      intronic chr5:137528653(-) A-I      intronic chr5:137543811(-) A-I      intronic chr5:137548271(-) A-I      intronic chr5:137535985(-) A-I      intronic chr5:137540473(-) A-I      intronic chr5:137525999(-) A-I      intronic chr5:137533773(-) A-I      intronic chr5:137539435(-) A-I      intronic chr5:137526922(-) A-I      intronic chr5:137544673(-) A-I      intronic chr5:137538075(-) A-I      intronic chr5:137539344(-) A-I      intronic chr5:137536409(-) A-I      intronic chr5:137530012(-) A-I      intronic chr5:137538078(-) A-I      intronic chr5:137536365(-) A-I      intronic chr5:137538110(-) A-I      intronic chr5:137538151(-) A-I      intronic chr5:137526957(-) A-I      intronic chr5:137545017(-) A-I      intronic chr5:137544667(-) A-I      intronic chr5:137536397(-) A-I      intronic chr5:137536387(-) A-I      intronic chr5:137542745(-) A-I      intronic chr5:137546181(-) A-I      intronic chr5:137536462(-) A-I      intronic chr5:137540582(-) A-I      intronic chr5:137530479(-) A-I      intronic chr5:137544682(-) A-I      intronic chr5:137543546(-) A-I      intronic chr5:137536304(-) A-I      intronic chr5:137536423(-) A-I      intronic chr5:137540031(-) A-I      intronic chr5:137535857(-) A-I      intronic chr5:137544979(-) A-I      intronic chr5:137536343(-) A-I      intronic chr5:137530034(-) A-I      intronic chr5:137535912(-) A-I      intronic chr5:137539409(-) A-I      intronic chr5:137536427(-) A-I      intronic chr5:137539937(-) A-I      intronic chr5:137535856(-) A-I      intronic chr5:137543502(-) A-I      intronic chr5:137535849(-) A-I      intronic chr5:137528711(-) A-I      intronic chr5:137526281(-) A-I      intronic chr5:137544532(-) A-I      intronic chr5:137547270(-) A-I      intronic chr5:137540099(-) A-I      intronic chr5:137540715(-) A-I      intronic chr5:137536505(-) A-I      intronic chr5:137544681(-) A-I      intronic chr5:137528817(-) A-I      intronic chr5:137536116(-) A-I      intronic chr5:137548264(-) A-I      intronic chr5:137536361(-) A-I      intronic chr5:137538146(-) A-I      intronic chr5:137547269(-) A-I      intronic chr5:137526980(-) A-I      intronic chr5:137535923(-) A-I      intronic chr5:137526931(-) A-I      intronic chr5:137536507(-) A-I      intronic chr5:137539526(-) A-I      intronic chr5:137536422(-) A-I      intronic chr5:137540094(-) A-I      intronic chr5:137528849(-) A-I      intronic chr5:137548200(-) A-I      intronic chr5:137536401(-) A-I      intronic chr5:137535981(-) A-I      intronic chr5:137547240(-) A-I      intronic chr5:137540406(-) A-I      intronic chr5:137526399(-) A-I      intronic chr5:137525902(-) A-I      intronic chr5:137525929(-) A-I      intronic chr5:137535958(-) A-I      intronic chr5:137540682(-) A-I      intronic chr5:137525974(-) A-I      intronic chr5:137540111(-) A-I      intronic chr5:137525998(-) A-I      intronic chr5:137528813(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC23	chr5:137526957(-) A-G intron -    22484847 chr5:137526958(-) A-G intron -    22484847 chr5:137526980(-) A-G intron -    22484847 chr5:137529266(-) A-G intron -    22484847 chr5:137529973(-) A-G intron -    22484847 chr5:137533324(-) A-G intron -    22484847 chr5:137535923(-) A-G intron -    22484847 chr5:137535931(-) A-G intron -    22484847 chr5:137535958(-) A-G intron -    22484847 chr5:137535959(-) A-G intron -    22484847 chr5:137535981(-) A-G intron -    22484847 chr5:137535985(-) A-G intron -    22484847 chr5:137536397(-) A-G intron -    22484847 chr5:137536401(-) A-G intron -    22484847 chr5:137536409(-) A-G intron -    22484847 chr5:137536422(-) A-G intron -    22484847 chr5:137536423(-) A-G intron -    22484847 chr5:137536426(-) A-G intron -    22484847 chr5:137537256(-) T-C intron -    22484847 chr5:137539350(-) A-G intron -    22484847 chr5:137539526(-) A-G intron -    22484847 chr5:137540036(-) A-G intron -    22484847 chr5:137540086(-) A-G intron -    22484847 chr5:137540094(-) A-G intron -    22484847 chr5:137540099(-) A-G intron -    22484847 chr5:137540111(-) A-G intron -    22484847 chr5:137540137(-) A-G intron -    22484847 chr5:137540406(-) A-G intron -    22484847 chr5:137540658(-) A-G intron -    22484847 chr5:137540715(-) A-G intron -    22484847 chr5:137543502(-) A-G intron -    22484847 chr5:137543546(-) A-G intron -    22484847 chr5:137543811(-) A-G intron -    22484847 chr5:137543828(-) A-G intron -    22484847 chr5:137543829(-) A-G intron -    22484847 chr5:137544673(-) A-G intron -    22484847 chr5:137544681(-) A-G intron -    22484847 chr5:137544682(-) A-G intron -    22484847 chr5:137545078(-) A-G intron -    22484847 chr5:137545091(-) A-G intron -    22484847 chr5:137546043(-) T-C intron -    22484847 chr5:137546174(-) A-G intron -    22484847 chr5:137546181(-) A-G intron -    22484847 chr5:137546206(-) A-G intron -    22484847 chr5:137547240(-) A-G intron -    22484847 chr5:137547269(-) A-G intron -    22484847 chr5:137547270(-) A-G intron -    22484847 chr5:137548271(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC23	chr5:137523867-137523868(-) m6A 3'UTR       24981863 chr5:137523877-137523878(-) m6A 3'UTR       24981863 chr5:137523908-137523909(-) m6A 3'UTR       24981863 chr5:137524006-137524007(-) m6A 3'UTR       24981863 chr5:137524776-137524777(-) m6A CDS//exon       27773535 chr5:137524787-137524788(-) m6A CDS//exon       27773535 chr5:137528229-137528230(-) Gm CDS//exon       - chr5:137536629-137536630(-) m6A exon//intron       - chr5:137537120-137537121(-) m6A 3'UTR//CDS//exon       24981863 chr5:137537816-137537817(-) m6A CDS//exon//intron       24981863 chr5:137541652-137541653(-) m6A 3'UTR//intron       27773535 chr5:137541714-137541715(-) m6A 3'UTR//intron       27773535 chr5:137541775-137541776(-) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-5p	Exosome B cell line (Raji)     21505438
	CDC23	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-5p
Interactor2: CDC23

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.