Basic Information:

  VIRBase ID:  

VHID00406115

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-5p:  MIMAT0004836          API5:  NR_024625     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-5p	API5
miRBase Accession/Entrez ID	MIMAT0004836	8539
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AAC-11//AAC11

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	API5	chr11:43362067(+) A-I      intronic chr11:43362100(+) A-I      intronic chr11:43362101(+) A-I      intronic chr11:43362128(+) A-I      intronic chr11:43339677(+) A-I      intronic chr11:43342093(+) A-I      intronic chr11:43362135(+) A-I      intronic chr11:43341856(+) A-I      intronic chr11:43341183(+) A-I      intronic chr11:43345733(+) A-I      intronic chr11:43342173(+) A-I      intronic chr11:43342045(+) A-I      intronic chr11:43338196(+) A-I      intronic chr11:43342131(+) A-I      intronic chr11:43339591(+) A-I      intronic chr11:43334456(+) A-I      intronic chr11:43339618(+) A-I      intronic chr11:43338347(+) A-I      intronic chr11:43338350(+) A-I      intronic chr11:43339585(+) A-I      intronic chr11:43339634(+) A-I      intronic chr11:43339370(+) A-I      intronic chr11:43346059(+) A-I      intronic chr11:43341184(+) A-I      intronic chr11:43341228(+) A-I      intronic chr11:43345725(+) A-I      intronic chr11:43339449(+) A-I      intronic chr11:43334498(+) A-I      intronic chr11:43335361(+) A-I      intronic chr11:43345713(+) A-I      intronic chr11:43346096(+) A-I      intronic chr11:43346050(+) A-I      intronic chr11:43346121(+) A-I      intronic chr11:43335397(+) A-I      intronic chr11:43339583(+) A-I      intronic chr11:43342112(+) A-I      intronic chr11:43342138(+) A-I      intronic chr11:43339500(+) A-I      intronic chr11:43341050(+) A-I      intronic chr11:43346051(+) A-I      intronic chr11:43339345(+) A-I      intronic chr11:43342130(+) A-I      intronic chr11:43339488(+) A-I      intronic chr11:43339408(+) A-I      intronic chr11:43335398(+) A-I      intronic chr11:43346119(+) A-I      intronic chr11:43345806(+) A-I      intronic chr11:43345363(+) A-I      intronic chr11:43339660(+) A-I      intronic chr11:43342038(+) A-I      intronic chr11:43342230(+) A-I      intronic chr11:43345829(+) A-I      intronic chr11:43342069(+) A-I      intronic chr11:43341197(+) A-I      intronic chr11:43345782(+) A-I      intronic chr11:43341042(+) A-I      intronic chr11:43339327(+) A-I      intronic chr11:43339769(+) A-I      intronic chr11:43345751(+) A-I      intronic chr11:43339773(+) A-I      intronic chr11:43335414(+) A-I      intronic chr11:43346044(+) A-I      intronic chr11:43335478(+) A-I      intronic chr11:43339699(+) A-I      intronic chr11:43342238(+) A-I      intronic chr11:43338334(+) A-I      intronic chr11:43342220(+) A-I      intronic chr11:43339701(+) A-I      intronic chr11:43342215(+) A-I      intronic chr11:43339328(+) A-I      intronic chr11:43339709(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	API5	chr11:43345751(+) A-G intron -    22484847 chr11:43345782(+) A-G intron -    22484847 chr11:43346119(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	API5	chr11:43333637-43333638(+) m6A 5'UTR//exon       24981863 chr11:43333651-43333652(+) m6A 5'UTR//exon       24981863 chr11:43360808-43360809(+) m6A exon//intron       22608085 chr11:43360816-43360817(+) m6A exon//intron       22608085 chr11:43360832-43360833(+) m6A exon//intron       24981863//22608085 chr11:43360907-43360908(+) m6A exon//intron       24981863//22608085 chr11:43360915-43360916(+) m6A exon//intron       24209618//24981863//22608085 chr11:43364050-43364051(+) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//22608085 chr11:43364065-43364066(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr11:43364147-43364148(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr11:43364171-43364172(+) m6A 3'UTR//CDS       24284625//24209618//24981863//22608085 chr11:43364219-43364220(+) m6A 3'UTR       24981863//22608085 chr11:43364242-43364243(+) m6A 3'UTR       24981863//22608085 chr11:43364308-43364309(+) m6A 3'UTR       - chr11:43364331-43364332(+) m6A 3'UTR       - chr11:43365609-43365610(+) m6A 3'UTR       24981863//27773535 chr11:43365621-43365622(+) m6A 3'UTR       24981863//27773535 chr11:43365633-43365634(+) m6A 3'UTR       24981863//27773535 chr11:43365639-43365640(+) m6A 3'UTR       24981863//27773535 chr11:43365656-43365657(+) m6A 3'UTR       24981863//27773535 chr11:43365685-43365686(+) m6A 3'UTR       24981863 chr11:43365703-43365704(+) m6A 3'UTR       24981863 chr11:43365831-43365832(+) m6A 3'UTR       27773535 chr11:43365838-43365839(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-5p	Exosome B cell line (Raji)     21505438
	API5	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-5p
Interactor2: API5

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.