Detail Information

Basic Information:


  VIRBase ID:  

VHID00405845

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-5p:           PSAP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART19-5p PSAP
miRBase
Accession/Entrez ID		 MIMAT0004836 5660
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - GLBA//SAP1//SAP2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PSAP
chr10:73599172(-) A-I      intronic
chr10:73598494(-) A-I      intronic
chr10:73599070(-) A-I      intronic
chr10:73609248(-) A-I      intronic
chr10:73599377(-) A-I      intronic
chr10:73609275(-) A-I      intronic
chr10:73609258(-) A-I      intronic
chr10:73599476(-) A-I      intronic
chr10:73599355(-) A-I      intronic
chr10:73599442(-) A-I      intronic
chr10:73599471(-) A-I      intronic
chr10:73599085(-) A-I      intronic
chr10:73599364(-) A-I      intronic
chr10:73587031(-) A-I      intronic
chr10:73586378(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PSAP
chr10:73599364(-) A-I intron -    15258596
chr10:73599442(-) A-I intron -    15258596
chr10:73599471(-) A-I intron -    15258596
chr10:73599476(-) A-I intron -    15258596
chr10:73581769(-) T-A intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PSAP
chr10:73576420-73576421(-) Y 3'UTR       25219674//26075521
chr10:73576436-73576437(-) m6A 3'UTR       22575960
chr10:73576616-73576617(-) m6A 3'UTR       26404942
chr10:73576730-73576731(-) m6A 3'UTR       26404942
chr10:73576743-73576744(-) m6A 3'UTR       26404942
chr10:73576775-73576776(-) m6A 3'UTR       26404942
chr10:73577013-73577014(-) m6A 3'UTR       26404942
chr10:73577120-73577121(-) Cm 3'UTR       -
chr10:73577169-73577170(-) m6A 3'UTR       26404942//22575960
chr10:73577201-73577202(-) m6A CDS       26404942//22575960
chr10:73578390-73578391(-) m6A CDS//exon       26404942//22575960
chr10:73578398-73578399(-) m6A CDS//exon       26404942//22575960
chr10:73578438-73578439(-) m6A CDS//exon       26404942//22575960
chr10:73579237-73579238(-) m6A CDS       26404942
chr10:73579294-73579295(-) m6A CDS       26404942//22575960
chr10:73579577-73579578(-) m6A CDS//exon//intron       26404942
chr10:73580001-73580002(-) m6A CDS//exon//intron       26404942
chr10:73581650-73581651(-) m6A CDS//exon//intron       26404942//22575960
chr10:73581700-73581701(-) m6A CDS//exon//intron       26404942//27773535//22575960
chr10:73581937-73581938(-) m6A exon//intron       26404942
chr10:73585642-73585643(-) m6A CDS//intron       26404942
chr10:73587818-73587819(-) m6A CDS//intron       26404942//22575960
chr10:73587850-73587851(-) m6A CDS//intron       26404942//22575960
chr10:73587862-73587863(-) m6A CDS//intron       26404942//22575960
chr10:73587891-73587892(-) m6A CDS//intron       26404942//22575960
chr10:73588721-73588722(-) m6A CDS//intron       26404942
chr10:73590901-73590902(-) m6A CDS//intron       26404942//22575960
chr10:73590925-73590926(-) m6A CDS//intron       26404942//22575960
chr10:73590955-73590956(-) m6A CDS//intron       26404942//27371828//27773536//22575960
chr10:73590960-73590961(-) m6A CDS//intron       26404942//27371828//27773536//22575960
chr10:73590980-73590981(-) m6A CDS//intron       26404942//27371828//27773536//22575960
chr10:73591615-73591616(-) m6A CDS       26404942//27371828//27773536
chr10:73594141-73594142(-) m6A CDS       26404942//27371828//27773536//22575960
chr10:73594151-73594152(-) m6A CDS       26404942//27371828//27773536//22575960
chr10:73594239-73594240(-) m6A CDS       24284625//24981863//26404942//27371828//22575960
chr10:73610998-73610999(-) m6A 5'UTR       24284625//24981863//26404942//27371828//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BART19-5p
Exosome B cell line (Raji)     21505438
PSAP
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART19-5p
Interactor2: PSAP

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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