Basic Information:

  VIRBase ID:  

VHID00405619

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART19-5p:  MIMAT0004836          IRF4:  NR_046000     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART19-5p	IRF4
miRBase Accession/Entrez ID	MIMAT0004836	3662
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	LSIRF//MUM1//NF-EM5//SHEP8

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IRF4	chr6:406463(+) A-I      intronic chr6:406474(+) A-I      intronic chr6:407708(+) A-I      3'UTR chr6:407778(+) A-I      3'UTR chr6:402790(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IRF4	chr6:400716(+) A-I intron -    22327324 chr6:402754(+) A-T intron -    22484847 chr6:402790(+) A-G intron -    22484847 chr6:402820(+) C-T intron -    22484847 chr6:402873(+) G-A intron -    22484847 chr6:402931(+) A-C intron -    22484847 chr6:402947(+) G-A intron -    22484847 chr6:402982(+) T-C intron -    22484847 chr6:406309(+) T-C intron -    22484847 chr6:406463(+) A-G intron -    22484847 chr6:406541(+) C-A intron -    22484847 chr6:407630(+) T-C intron -    22484847 chr6:407649(+) G-T intron -    22484847 chr6:407708(+) A-G intron -    22484847 chr6:407778(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IRF4	chr6:391773-391774(+) m6A 5'UTR//exon       27371828 chr6:393119-393120(+) m6A 5'UTR//intron       27371828 chr6:393156-393157(+) m6A CDS//intron       27371828 chr6:393333-393334(+) m6A CDS//exon//intron       26404942 chr6:394869-394870(+) m6A CDS//exon       26404942 chr6:394908-394909(+) m6A CDS//exon       26404942 chr6:394930-394931(+) m6A CDS//exon       26404942 chr6:394953-394954(+) m6A CDS//exon       26404942 chr6:394962-394963(+) m6A CDS//exon       26404942 chr6:395870-395871(+) m6A CDS//exon       - chr6:396003-396004(+) m6A exon//intron       - chr6:396018-396019(+) m6A exon//intron       - chr6:396026-396027(+) m6A exon//intron       - chr6:396065-396066(+) m6A exon//intron       - chr6:397153-397154(+) m6A CDS//exon       - chr6:397211-397212(+) m6A CDS//exon       - chr6:397485-397486(+) m6A exon//intron       - chr6:397516-397517(+) m6A exon//intron       - chr6:398844-398845(+) m6A CDS       - chr6:401514-401515(+) m6A CDS       26404942 chr6:401540-401541(+) m6A CDS       26404942 chr6:401567-401568(+) m6A CDS       26404942 chr6:401585-401586(+) m6A CDS       26404942 chr6:401661-401662(+) m6A CDS       26404942 chr6:401724-401725(+) m6A CDS       26404942 chr6:401735-401736(+) m6A CDS       26404942 chr6:401740-401741(+) m6A CDS       26404942 chr6:405095-405096(+) m6A CDS       - chr6:406875-406876(+) m6A 3'UTR//intron       - chr6:407459-407460(+) m6A 3'UTR//CDS       26404942 chr6:407474-407475(+) m6A 3'UTR//CDS       26404942 chr6:407500-407501(+) m6A 3'UTR//CDS       26404942 chr6:407507-407508(+) m6A 3'UTR//CDS       26404942 chr6:407537-407538(+) m6A 3'UTR//CDS       26404942 chr6:407742-407743(+) m6A 3'UTR       26404942 chr6:407806-407807(+) m6A 3'UTR       26404942 chr6:407929-407930(+) m6A 3'UTR       25456834//26404942 chr6:408015-408016(+) m6A 3'UTR       26404942 chr6:408116-408117(+) m6A 3'UTR       26404942 chr6:408125-408126(+) m6A 3'UTR       26404942 chr6:408275-408276(+) m6A 3'UTR       - chr6:408439-408440(+) m6A 3'UTR       - chr6:408464-408465(+) m6A 3'UTR       - chr6:408488-408489(+) m6A 3'UTR       - chr6:408616-408617(+) m6A 3'UTR       26404942 chr6:408636-408637(+) m6A 3'UTR       26404942 chr6:408755-408756(+) m6A 3'UTR       - chr6:408782-408783(+) m6A 3'UTR       - chr6:408818-408819(+) m6A 3'UTR       - chr6:409622-409623(+) m6A 3'UTR       26404942 chr6:409636-409637(+) m6A 3'UTR       26404942 chr6:409717-409718(+) m6A 3'UTR       26404942 chr6:410087-410088(+) m6A 3'UTR       26404942 chr6:410142-410143(+) m6A 3'UTR       26404942 chr6:410168-410169(+) m6A 3'UTR       26404942 chr6:410191-410192(+) m6A 3'UTR       26404942 chr6:410292-410293(+) m6A 3'UTR       26404942 chr6:410321-410322(+) m6A 3'UTR       26404942 chr6:410333-410334(+) m6A 3'UTR       26404942 chr6:410362-410363(+) m6A 3'UTR       26404942 chr6:410392-410393(+) m6A 3'UTR       26404942 chr6:410419-410420(+) m6A 3'UTR       26404942 chr6:410429-410430(+) m6A 3'UTR       26404942 chr6:410443-410444(+) m6A 3'UTR       26404942 chr6:410454-410455(+) m6A 3'UTR       26404942 chr6:411030-411031(+) m6A 3'UTR       26404942 chr6:411128-411129(+) m6A 3'UTR       26404942 chr6:411134-411135(+) m6A 3'UTR       26404942 chr6:411143-411144(+) m6A 3'UTR       26404942 chr6:411211-411212(+) m6A 3'UTR       26404942 chr6:411227-411228(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BART19-5p	Exosome B cell line (Raji)     21505438
	IRF4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART19-5p
Interactor2: IRF4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.