Detail Information

Basic Information:


  VIRBase ID:  

VHID00398586

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:           ZSCAN29:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART9-5p ZSCAN29
miRBase
Accession/Entrez ID		 MIMAT0004816 146050
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - Zfp690//ZNF690

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZSCAN29
chr15:43650466(-) A-C exon 3'UTR    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZSCAN29
chr15:43650808-43650809(-) Am 3'UTR       -
chr15:43650858-43650859(-) m6A 3'UTR       24981863//27773535
chr15:43650878-43650879(-) m6A 3'UTR       24981863//27773535
chr15:43650959-43650960(-) m6A 3'UTR       27773535
chr15:43650998-43650999(-) m6A 3'UTR       27773535
chr15:43651048-43651049(-) m6A 3'UTR       27773535
chr15:43651064-43651065(-) m6A 3'UTR       27773535
chr15:43651083-43651084(-) m6A 3'UTR       27773535
chr15:43651142-43651143(-) m6A 3'UTR       24981863//27773535
chr15:43651182-43651183(-) m6A 3'UTR       24981863//27773535
chr15:43651200-43651201(-) m6A 3'UTR       24981863//27773535
chr15:43651285-43651286(-) m6A 3'UTR       24981863//27773535
chr15:43651673-43651674(-) m6A 3'UTR       24981863
chr15:43651738-43651739(-) m6A 3'UTR       24284625//24981863
chr15:43651752-43651753(-) m6A 3'UTR       24284625//24981863
chr15:43651856-43651857(-) m6A 3'UTR       24284625
chr15:43652203-43652204(-) m6A 3'UTR       24981863
chr15:43652457-43652458(-) m6A 3'UTR       24284625
chr15:43653381-43653382(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43653398-43653399(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr15:43653465-43653466(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr15:43653566-43653567(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43653633-43653634(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43653717-43653718(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43653744-43653745(-) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43653841-43653842(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr15:43653882-43653883(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr15:43653900-43653901(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr15:43653948-43653949(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr15:43653971-43653972(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr15:43653984-43653985(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr15:43654067-43654068(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr15:43656033-43656034(-) m6A 3'UTR//intron       -
chr15:43656253-43656254(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr15:43656277-43656278(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr15:43656355-43656356(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr15:43656394-43656395(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43656415-43656416(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43656425-43656426(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43656433-43656434(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43656501-43656502(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr15:43656526-43656527(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43656550-43656551(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43656556-43656557(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085
chr15:43656643-43656644(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535
chr15:43658348-43658349(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr15:43658454-43658455(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr15:43658571-43658572(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658621-43658622(-) Am 3'UTR//CDS//intron       -
chr15:43658631-43658632(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658641-43658642(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658649-43658650(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658705-43658706(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658717-43658718(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658742-43658743(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658772-43658773(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658833-43658834(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658891-43658892(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43658917-43658918(-) m6A CDS//intron       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr15:43661136-43661137(-) m6A CDS       24981863//27773535
chr15:43661155-43661156(-) m6A CDS       27773535
chr15:43661172-43661173(-) m6A CDS       27773535
chr15:43661179-43661180(-) m6A CDS       27773535
chr15:43661226-43661227(-) m6A CDS       24981863//27773535
chr15:43661805-43661806(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:43661871-43661872(-) m6A 5'UTR//CDS       24284625//24209618//24981863//27773535//27371828//22608085
chr15:43661934-43661935(-) m6A 5'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr15:43661988-43661989(-) m6A 5'UTR//CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr15:43662065-43662066(-) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr15:43662145-43662146(-) m6A 5'UTR       24284625//24209618//24981863//22608085
chr15:43662151-43662152(-) m6A 5'UTR       24284625//24209618//24981863//22608085
chr15:43662179-43662180(-) m6A 5'UTR       24284625//24209618//24981863//22608085
chr15:43662216-43662217(-) m6A 5'UTR//exon       24284625//24209618//24981863//22608085
chr15:43662269-43662270(-) m6A exon//intron       24284625//24981863
chr15:43662276-43662277(-) m6A exon//intron       24284625//24981863
chr15:43662420-43662421(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr15:43662488-43662489(-) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//22608085
chr15:43662513-43662514(-) m6A exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr15:43662789-43662790(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085
chr15:43662925-43662926(-) m6A 5'UTR//exon       24284625//25456834//24981863//27371828//27773536
chr15:43662985-43662986(-) m6A 5'UTR//exon       24284625//25456834//27371828//27773536//22608085
chr15:43663027-43663028(-) m6A 5'UTR//exon       24284625//25456834//24981863//27371828//27773536//22608085
chr15:43663162-43663163(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZSCAN29
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART9-5p
Interactor2: ZSCAN29

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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