Basic Information:

  VIRBase ID:  

VHID00398330

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          CEP44:  NM_001040157     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	CEP44
miRBase Accession/Entrez ID	MIMAT0004816	80817
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAA1712//PS1TP3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP44	chr4:175233559(+) A-I      intronic chr4:175251408(+) A-I      intronic chr4:175250337(+) A-I      intronic chr4:175250202(+) A-I      intronic chr4:175250159(+) A-I      intronic chr4:175246597(+) A-I      intronic chr4:175233496(+) A-I      intronic chr4:175233488(+) A-I      intronic chr4:175226462(+) A-I      intronic chr4:175239356(+) A-I      3'UTR chr4:175239332(+) A-I      3'UTR chr4:175239314(+) A-I      3'UTR chr4:175239315(+) A-I      3'UTR chr4:175246771(+) A-I      intronic chr4:175246623(+) A-I      intronic chr4:175250153(+) A-I      intronic chr4:175246691(+) A-I      intronic chr4:175250227(+) A-I      intronic chr4:175250231(+) A-I      intronic chr4:175240147(+) A-I      3'UTR chr4:175250116(+) A-I      intronic chr4:175246549(+) A-I      intronic chr4:175246664(+) A-I      intronic chr4:175246761(+) A-I      intronic chr4:175250299(+) A-I      intronic chr4:175251384(+) A-I      intronic chr4:175250237(+) A-I      intronic chr4:175233502(+) A-I      intronic chr4:175250198(+) A-I      intronic chr4:175211273(+) A-I      intronic chr4:175236858(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP44	chr4:175246549(+) A-I intron -    22327324 chr4:175239285(+) G-A intron -    22484847 chr4:175246549(+) A-G intron -    22484847 chr4:175246664(+) A-G intron -    22484847 chr4:175246691(+) A-G intron -    22484847 chr4:175246771(+) A-G intron -    22484847 chr4:175250116(+) A-G intron -    22484847 chr4:175250151(+) A-G intron -    22484847 chr4:175250153(+) A-G intron -    22484847 chr4:175250227(+) A-G intron -    22484847 chr4:175250299(+) A-G intron -    22484847 chr4:175250336(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP44	chr4:175204946-175204947(+) m6A 5'UTR       24981863 chr4:175204972-175204973(+) m6A 5'UTR       24981863 chr4:175205111-175205112(+) m6A 5'UTR//intron       24981863 chr4:175205198-175205199(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr4:175238495-175238496(+) m6A CDS//intron       24981863 chr4:175238872-175238873(+) m6A 3'UTR//intron       24981863 chr4:175238896-175238897(+) m6A 3'UTR//intron       24981863 chr4:175238910-175238911(+) m6A 3'UTR//intron       24981863 chr4:175240837-175240838(+) Y 3'UTR//intron       26075521 chr4:175252883-175252884(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CEP44	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: CEP44

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.