Basic Information:

  VIRBase ID:  

VHID00398133

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          FAM219B:  NR_135848     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	FAM219B
miRBase Accession/Entrez ID	MIMAT0004816	57184
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C15orf17

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM219B	chr15:75196687(-) A-I      intronic chr15:75196665(-) A-I      intronic chr15:75195676(-) A-I      intronic chr15:75196761(-) A-I      intronic chr15:75196743(-) A-I      intronic chr15:75196769(-) A-I      intronic chr15:75196668(-) A-I      intronic chr15:75195685(-) A-I      intronic chr15:75193599(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	FAM219B	chr15:75193948(-) A-I exon 3'UTR    22327324 chr15:75196769(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	FAM219B	chr15:75193771-75193772(-) m6A 3'UTR//exon//intron       - chr15:75193812-75193813(-) m6A 3'UTR//exon//intron       - chr15:75193982-75193983(-) Cm 3'UTR//exon//intron       - chr15:75194958-75194959(-) m6A 3'UTR//exon       24284625//24981863//22608085 chr15:75194984-75194985(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr15:75195047-75195048(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr15:75195053-75195054(-) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr15:75195119-75195120(-) m6A 3'UTR//CDS//exon       24284625 chr15:75198633-75198634(-) m6A CDS//exon//intron       27773536 chr15:75198642-75198643(-) m6A CDS//exon//intron       27773536 chr15:75198693-75198694(-) m6A 5'UTR//CDS//exon//intron       27773536 chr15:75198736-75198737(-) m6A 5'UTR//intron       27773536 chr15:75199067-75199068(-) m6A CDS//exon       24981863//27371828//27773536 chr15:75199090-75199091(-) m6A CDS//exon       24981863//27371828//27773536 chr15:75199272-75199273(-) m6A 5'UTR       - chr15:75199280-75199281(-) m6A 5'UTR       - chr15:75199301-75199302(-) m6A 5'UTR       24284625 chr15:75199332-75199333(-) m6A 5'UTR       24284625 chr15:75199344-75199345(-) m6A 5'UTR       24284625 chr15:75199386-75199387(-) m6A 5'UTR       24284625 chr15:75199391-75199392(-) m6A 5'UTR       24284625 chr15:75199459-75199460(-) m6A 5'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM219B	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: FAM219B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.