Basic Information:

  VIRBase ID:  

VHID00398072

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          ELAC1:  NM_018696     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	ELAC1
miRBase Accession/Entrez ID	MIMAT0004816	55520
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	D29

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ELAC1	chr18:48511208(+) A-I      intronic chr18:48506236(+) A-I      intronic chr18:48506231(+) A-I      intronic chr18:48506214(+) A-I      intronic chr18:48506190(+) A-I      intronic chr18:48506174(+) A-I      intronic chr18:48510037(+) A-I      intronic chr18:48510094(+) A-I      intronic chr18:48510103(+) A-I      intronic chr18:48510130(+) A-I      intronic chr18:48511235(+) A-I      intronic chr18:48511251(+) A-I      intronic chr18:48506524(+) A-I      intronic chr18:48509553(+) A-I      intronic chr18:48509555(+) A-I      intronic chr18:48512493(+) A-I      intronic chr18:48511265(+) A-I      intronic chr18:48511222(+) A-I      intronic chr18:48506369(+) A-I      intronic chr18:48509635(+) A-I      intronic chr18:48512584(+) A-I      intronic chr18:48506498(+) A-I      intronic chr18:48506513(+) A-I      intronic chr18:48507087(+) A-I      intronic chr18:48511246(+) A-I      intronic chr18:48509724(+) A-I      intronic chr18:48509986(+) A-I      intronic chr18:48510211(+) A-I      intronic chr18:48510003(+) A-I      intronic chr18:48509985(+) A-I      intronic chr18:48512489(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ELAC1	chr18:48494982-48494983(+) m6A exon//intron       25456834//22608085 chr18:48510504-48510505(+) m6A CDS//intron       24981863 chr18:48510571-48510572(+) m6A CDS//intron       24284625//24981863//22608085 chr18:48510609-48510610(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr18:48510623-48510624(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr18:48510631-48510632(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr18:48510673-48510674(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr18:48510709-48510710(+) m6A CDS//intron       24284625//25456834//24981863//22608085 chr18:48510741-48510742(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22608085 chr18:48510760-48510761(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:48510770-48510771(+) m6A CDS//intron       24284625//24209618//24981863//22608085 chr18:48510783-48510784(+) m6A CDS//intron       24981863//22608085 chr18:48510795-48510796(+) m6A CDS//intron       24981863//22608085 chr18:48510820-48510821(+) m6A CDS//intron       24981863//22608085 chr18:48510904-48510905(+) m6A CDS       24981863//22608085 chr18:48510919-48510920(+) m6A CDS       24981863//22608085 chr18:48510927-48510928(+) m6A CDS       22608085 chr18:48513154-48513155(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr18:48513171-48513172(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr18:48513213-48513214(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22608085 chr18:48513319-48513320(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr18:48513347-48513348(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr18:48513364-48513365(+) m6A CDS       24209618//25456834//24981863//22608085 chr18:48513456-48513457(+) m6A 3'UTR       24209618//24981863//22608085 chr18:48513504-48513505(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ELAC1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: ELAC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.