Detail Information

Basic Information:


  VIRBase ID:  

VHID00397104

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:           GLS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART9-5p GLS
miRBase
Accession/Entrez ID		 MIMAT0004816 2744
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - AAD20//CASGID//DEE71//EIEE71//GAC//GAM//GDPAG//GLS1//KGA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GLS
chr2:191751446(+) A-I      intronic
chr2:191807251(+) A-I      intronic
chr2:191751465(+) A-I      intronic
chr2:191814238(+) A-I      intronic
chr2:191751455(+) A-I      intronic
chr2:191751486(+) A-I      intronic
chr2:191751422(+) A-I      intronic
chr2:191814234(+) A-I      intronic
chr2:191782553(+) A-I      intronic
chr2:191782559(+) A-I      intronic
chr2:191782560(+) A-I      intronic
chr2:191814233(+) A-I      intronic
chr2:191814224(+) A-I      intronic
chr2:191751466(+) A-I      intronic
chr2:191810125(+) A-I      intronic
chr2:191754936(+) A-I      intronic
chr2:191749937(+) A-I      intronic
chr2:191749992(+) A-I      intronic
chr2:191750018(+) A-I      intronic
chr2:191750017(+) A-I      intronic
chr2:191750059(+) A-I      intronic
chr2:191750084(+) A-I      intronic
chr2:191750113(+) A-I      intronic
chr2:191750838(+) A-I      intronic
chr2:191750889(+) A-I      intronic
chr2:191751456(+) A-I      intronic
chr2:191751491(+) A-I      intronic
chr2:191751492(+) A-I      intronic
chr2:191751515(+) A-I      intronic
chr2:191754930(+) A-I      intronic
chr2:191754949(+) A-I      intronic
chr2:191810127(+) A-I      intronic
chr2:191789457(+) A-I      intronic
chr2:191789485(+) A-I      intronic
chr2:191810111(+) A-I      intronic
chr2:191750057(+) A-I      intronic
chr2:191789507(+) A-I      intronic
chr2:191774586(+) A-I      intronic
chr2:191761778(+) A-I      intronic
chr2:191751410(+) A-I      intronic
chr2:191816749(+) A-I      intronic
chr2:191751587(+) A-I      intronic
chr2:191751495(+) A-I      intronic
chr2:191814242(+) A-I      intronic
chr2:191750047(+) A-I      intronic
chr2:191750190(+) A-I      intronic
chr2:191794819(+) A-I      intronic
chr2:191794989(+) A-I      intronic
chr2:191806988(+) A-I      intronic
chr2:191807069(+) A-I      intronic
chr2:191761893(+) A-I      intronic
chr2:191789530(+) A-I      intronic
chr2:191751386(+) A-I      intronic
chr2:191751413(+) A-I      intronic
chr2:191751612(+) A-I      intronic
chr2:191810319(+) A-I      intronic
chr2:191761932(+) A-I      intronic
chr2:191814158(+) A-I      intronic
chr2:191750063(+) A-I      intronic
chr2:191750083(+) A-I      intronic
chr2:191750099(+) A-I      intronic
chr2:191825176(+) A-I      intronic
chr2:191789432(+) A-I      intronic
chr2:191779846(+) A-I      intronic
chr2:191751408(+) A-I      intronic
chr2:191751480(+) A-I      intronic
chr2:191751387(+) A-I      intronic
chr2:191761832(+) A-I      intronic
chr2:191774584(+) A-I      intronic
chr2:191794905(+) A-I      intronic
chr2:191750150(+) A-I      intronic
chr2:191826090(+) A-I      intronic
chr2:191758563(+) A-I      intronic
chr2:191761855(+) A-I      intronic
chr2:191749968(+) A-I      intronic
chr2:191749998(+) A-I      intronic
chr2:191751522(+) A-I      intronic
chr2:191750192(+) A-I      intronic
chr2:191750804(+) A-I      intronic
chr2:191793815(+) A-I      intronic
chr2:191795058(+) A-I      intronic
chr2:191750178(+) A-I      intronic
chr2:191751464(+) A-I      intronic
chr2:191789596(+) A-I      intronic
chr2:191750668(+) A-I      intronic
chr2:191778779(+) A-I      intronic
chr2:191772031(+) A-I      intronic
chr2:191761926(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GLS
chr2:191749968(+) A-G intron -    22484847
chr2:191749982(+) A-G intron -    22484847
chr2:191749997(+) A-G intron -    22484847
chr2:191749998(+) A-G intron -    22484847
chr2:191750047(+) A-G intron -    22484847
chr2:191750057(+) A-G intron -    22484847
chr2:191750063(+) A-G intron -    22484847
chr2:191750096(+) A-G intron -    22484847
chr2:191750116(+) A-G intron -    22484847
chr2:191750178(+) A-G intron -    22484847
chr2:191750190(+) A-G intron -    22484847
chr2:191750668(+) A-G intron -    22484847
chr2:191750804(+) A-G intron -    22484847
chr2:191750846(+) T-C intron -    22484847
chr2:191751386(+) A-G intron -    22484847
chr2:191751387(+) A-G intron -    22484847
chr2:191751408(+) A-G intron -    22484847
chr2:191751410(+) A-G intron -    22484847
chr2:191751413(+) A-G intron -    22484847
chr2:191751464(+) A-G intron -    22484847
chr2:191751495(+) A-G intron -    22484847
chr2:191751522(+) A-G intron -    22484847
chr2:191751587(+) A-G intron -    22484847
chr2:191751612(+) A-G intron -    22484847
chr2:191758563(+) A-G intron -    22484847
chr2:191761857(+) T-C intron -    22484847
chr2:191789432(+) A-G intron -    22484847
chr2:191793772(+) C-T intron -    22484847
chr2:191794292(+) T-G intron -    22484847
chr2:191814158(+) A-G intron -    22484847
chr2:191816749(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GLS
chr2:191745575-191745576(+) m6A 5'UTR       24284625//24209618//24981863//22575960//22608085
chr2:191745676-191745677(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr2:191745731-191745732(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr2:191745749-191745750(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr2:191745800-191745801(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773536//22575960//22608085
chr2:191745844-191745845(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr2:191759886-191759887(+) m6A CDS//exon       24209618//24981863//22575960
chr2:191759940-191759941(+) m6A CDS//exon       -
chr2:191760364-191760365(+) Cm CDS//exon       -
chr2:191796314-191796315(+) m6A CDS//exon       24284625//27773535
chr2:191796329-191796330(+) m6A CDS//exon       24284625//27773535
chr2:191797387-191797388(+) m6A exon//intron       24284625//24981863//27773535//22608085
chr2:191797433-191797434(+) m6A exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797452-191797453(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797460-191797461(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797482-191797483(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797498-191797499(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797535-191797536(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:191797634-191797635(+) m6A 3'UTR//exon//intron       -
chr2:191799624-191799625(+) m6A 3'UTR//intron       26404942
chr2:191799640-191799641(+) m6A 3'UTR//intron       26404942
chr2:191799658-191799659(+) m6A 3'UTR//intron       26404942
chr2:191799698-191799699(+) m6A 3'UTR//intron       26404942
chr2:191827594-191827595(+) m6A CDS       24981863
chr2:191827679-191827680(+) m6A CDS       24981863
chr2:191827774-191827775(+) m6A 3'UTR       -
chr2:191829079-191829080(+) m6A 3'UTR       24981863
chr2:191829856-191829857(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GLS
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART9-5p
Interactor2: GLS

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression Downregulation
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

Starting a new search, please wait ...