Basic Information:

  VIRBase ID:  

VHID00397028

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          DDX6:  NM_004397     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	DDX6
miRBase Accession/Entrez ID	MIMAT0004816	1656
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HLR2//IDDILF//P54//RCK//Rck/p54

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DDX6	chr11:118658904(-) A-I      intronic chr11:118659622(-) A-I      intronic chr11:118659627(-) A-I      intronic chr11:118631763(-) A-I      intronic chr11:118654345(-) A-I      intronic chr11:118659983(-) A-I      intronic chr11:118647410(-) A-I      intronic chr11:118647394(-) A-I      intronic chr11:118654399(-) A-I      intronic chr11:118654403(-) A-I      intronic chr11:118624681(-) A-I      intronic chr11:118647376(-) A-I      intronic chr11:118654447(-) A-I      intronic chr11:118624761(-) A-I      intronic chr11:118658888(-) A-I      intronic chr11:118658903(-) A-I      intronic chr11:118623916(-) A-I      intronic chr11:118623876(-) A-I      intronic chr11:118659609(-) A-I      intronic chr11:118654320(-) A-I      intronic chr11:118653531(-) A-I      intronic chr11:118638523(-) A-I      intronic chr11:118624641(-) A-I      intronic chr11:118654459(-) A-I      intronic chr11:118640961(-) A-I      intronic chr11:118654453(-) A-I      intronic chr11:118654463(-) A-I      intronic chr11:118654469(-) A-I      intronic chr11:118640964(-) A-I      intronic chr11:118651151(-) A-I      intronic chr11:118654477(-) A-I      intronic chr11:118641028(-) A-I      intronic chr11:118654485(-) A-I      intronic chr11:118641364(-) A-I      intronic chr11:118654490(-) A-I      intronic chr11:118654595(-) A-I      intronic chr11:118654721(-) A-I      intronic chr11:118641508(-) A-I      intronic chr11:118623814(-) A-I      intronic chr11:118656122(-) A-I      intronic chr11:118656141(-) A-I      intronic chr11:118656165(-) A-I      intronic chr11:118658291(-) A-I      intronic chr11:118658763(-) A-I      intronic chr11:118658925(-) A-I      intronic chr11:118641369(-) A-I      intronic chr11:118658929(-) A-I      intronic chr11:118659142(-) A-I      intronic chr11:118641433(-) A-I      intronic chr11:118641479(-) A-I      intronic chr11:118623918(-) A-I      intronic chr11:118641482(-) A-I      intronic chr11:118641483(-) A-I      intronic chr11:118623952(-) A-I      intronic chr11:118659231(-) A-I      intronic chr11:118659271(-) A-I      intronic chr11:118646589(-) A-I      intronic chr11:118659280(-) A-I      intronic chr11:118659300(-) A-I      intronic chr11:118637398(-) A-I      intronic chr11:118646619(-) A-I      intronic chr11:118647354(-) A-I      intronic chr11:118647430(-) A-I      intronic chr11:118659302(-) A-I      intronic chr11:118647432(-) A-I      intronic chr11:118659325(-) A-I      intronic chr11:118647516(-) A-I      intronic chr11:118647527(-) A-I      intronic chr11:118659495(-) A-I      intronic chr11:118659496(-) A-I      intronic chr11:118659567(-) A-I      intronic chr11:118653501(-) A-I      intronic chr11:118659608(-) A-I      intronic chr11:118649638(-) A-I      intronic chr11:118624127(-) A-I      intronic chr11:118659632(-) A-I      intronic chr11:118659649(-) A-I      intronic chr11:118659900(-) A-I      intronic chr11:118650613(-) A-I      intronic chr11:118659917(-) A-I      intronic chr11:118659933(-) A-I      intronic chr11:118660024(-) A-I      intronic chr11:118654761(-) A-I      intronic chr11:118660033(-) A-I      intronic chr11:118660059(-) A-I      intronic chr11:118650620(-) A-I      intronic chr11:118660060(-) A-I      intronic chr11:118660066(-) A-I      intronic chr11:118650621(-) A-I      intronic chr11:118631136(-) A-I      intronic chr11:118650717(-) A-I      intronic chr11:118650742(-) A-I      intronic chr11:118650743(-) A-I      intronic chr11:118650773(-) A-I      intronic chr11:118650818(-) A-I      intronic chr11:118651116(-) A-I      intronic chr11:118637759(-) A-I      intronic chr11:118651190(-) A-I      intronic chr11:118651244(-) A-I      intronic chr11:118623957(-) A-I      intronic chr11:118651272(-) A-I      intronic chr11:118636890(-) A-I      intronic chr11:118651315(-) A-I      intronic chr11:118652407(-) A-I      intronic chr11:118624106(-) A-I      intronic chr11:118652474(-) A-I      intronic chr11:118651163(-) A-I      intronic chr11:118652518(-) A-I      intronic chr11:118624193(-) A-I      intronic chr11:118624222(-) A-I      intronic chr11:118624226(-) A-I      intronic chr11:118652525(-) A-I      intronic chr11:118624231(-) A-I      intronic chr11:118624275(-) A-I      intronic chr11:118624586(-) A-I      intronic chr11:118624592(-) A-I      intronic chr11:118624638(-) A-I      intronic chr11:118624661(-) A-I      intronic chr11:118623894(-) A-I      intronic chr11:118624109(-) A-I      intronic chr11:118652580(-) A-I      intronic chr11:118624677(-) A-I      intronic chr11:118624683(-) A-I      intronic chr11:118624693(-) A-I      intronic chr11:118624697(-) A-I      intronic chr11:118624744(-) A-I      intronic chr11:118624745(-) A-I      intronic chr11:118624750(-) A-I      intronic chr11:118624760(-) A-I      intronic chr11:118653442(-) A-I      intronic chr11:118623898(-) A-I      intronic chr11:118624763(-) A-I      intronic chr11:118653492(-) A-I      intronic chr11:118653502(-) A-I      intronic chr11:118624771(-) A-I      intronic chr11:118623875(-) A-I      intronic chr11:118624874(-) A-I      intronic chr11:118624894(-) A-I      intronic chr11:118653508(-) A-I      intronic chr11:118646622(-) A-I      intronic chr11:118652488(-) A-I      intronic chr11:118653527(-) A-I      intronic chr11:118624895(-) A-I      intronic chr11:118624934(-) A-I      intronic chr11:118624967(-) A-I      intronic chr11:118653532(-) A-I      intronic chr11:118624973(-) A-I      intronic chr11:118654125(-) A-I      intronic chr11:118624984(-) A-I      intronic chr11:118654140(-) A-I      intronic chr11:118625010(-) A-I      intronic chr11:118625022(-) A-I      intronic chr11:118624121(-) A-I      intronic chr11:118646801(-) A-I      intronic chr11:118653585(-) A-I      intronic chr11:118654362(-) A-I      intronic chr11:118625069(-) A-I      intronic chr11:118652537(-) A-I      intronic chr11:118625070(-) A-I      intronic chr11:118654363(-) A-I      intronic chr11:118654389(-) A-I      intronic chr11:118625107(-) A-I      intronic chr11:118654428(-) A-I      intronic chr11:118652836(-) A-I      intronic chr11:118631088(-) A-I      intronic chr11:118631100(-) A-I      intronic chr11:118631104(-) A-I      intronic chr11:118631109(-) A-I      intronic chr11:118631122(-) A-I      intronic chr11:118631133(-) A-I      intronic chr11:118635326(-) A-I      intronic chr11:118635412(-) A-I      intronic chr11:118635436(-) A-I      intronic chr11:118636320(-) A-I      intronic chr11:118636567(-) A-I      intronic chr11:118636576(-) A-I      intronic chr11:118636697(-) A-I      intronic chr11:118623902(-) A-I      intronic chr11:118636716(-) A-I      intronic chr11:118636733(-) A-I      intronic chr11:118636900(-) A-I      intronic chr11:118637018(-) A-I      intronic chr11:118637066(-) A-I      intronic chr11:118637090(-) A-I      intronic chr11:118637690(-) A-I      intronic chr11:118637331(-) A-I      intronic chr11:118637399(-) A-I      intronic chr11:118637450(-) A-I      intronic chr11:118637488(-) A-I      intronic chr11:118637514(-) A-I      intronic chr11:118623917(-) A-I      intronic chr11:118637538(-) A-I      intronic chr11:118624888(-) A-I      intronic chr11:118638337(-) A-I      intronic chr11:118638354(-) A-I      intronic chr11:118638408(-) A-I      intronic chr11:118639783(-) A-I      intronic chr11:118639808(-) A-I      intronic chr11:118640737(-) A-I      intronic chr11:118640796(-) A-I      intronic chr11:118640808(-) A-I      intronic chr11:118647420(-) A-I      intronic chr11:118647393(-) A-I      intronic chr11:118623555(-) A-I      intronic chr11:118658298(-) A-I      intronic chr11:118631114(-) A-I      intronic chr11:118652561(-) A-I      intronic chr11:118637789(-) A-I      intronic chr11:118650608(-) A-I      intronic chr11:118636916(-) A-I      intronic chr11:118632371(-) A-I      intronic chr11:118658776(-) A-I      intronic chr11:118637566(-) A-I      intronic chr11:118653536(-) A-I      intronic chr11:118638505(-) A-I      intronic chr11:118637559(-) A-I      intronic chr11:118637814(-) A-I      intronic chr11:118654141(-) A-I      intronic chr11:118636226(-) A-I      intronic chr11:118636563(-) A-I      intronic chr11:118651123(-) A-I      intronic chr11:118636240(-) A-I      intronic chr11:118652554(-) A-I      intronic chr11:118637551(-) A-I      intronic chr11:118624966(-) A-I      intronic chr11:118655634(-) A-I      intronic chr11:118638560(-) A-I      intronic chr11:118637530(-) A-I      intronic chr11:118653611(-) A-I      intronic chr11:118637533(-) A-I      intronic chr11:118652393(-) A-I      intronic chr11:118637791(-) A-I      intronic chr11:118638591(-) A-I      intronic chr11:118624228(-) A-I      intronic chr11:118658973(-) A-I      intronic chr11:118636732(-) A-I      intronic chr11:118640956(-) A-I      intronic chr11:118638590(-) A-I      intronic chr11:118653426(-) A-I      intronic chr11:118625012(-) A-I      intronic chr11:118636696(-) A-I      intronic chr11:118638568(-) A-I      intronic chr11:118658031(-) A-I      intronic chr11:118636719(-) A-I      intronic chr11:118652555(-) A-I      intronic chr11:118641496(-) A-I      intronic chr11:118624319(-) A-I      intronic chr11:118658976(-) A-I      intronic chr11:118624187(-) A-I      intronic chr11:118653533(-) A-I      intronic chr11:118645406(-) A-I      intronic chr11:118655347(-) A-I      intronic chr11:118645350(-) A-I      intronic chr11:118652392(-) A-I      intronic chr11:118637417(-) A-I      intronic chr11:118655631(-) A-I      intronic chr11:118619352(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DDX6	chr11:118638505(-) A-I intron -    15342557 chr11:118638560(-) A-I intron -    15342557 chr11:118638568(-) A-I intron -    15342557 chr11:118638590(-) A-I intron -    15342557 chr11:118638591(-) A-I intron -    15342557 chr11:118619352(-) A-I exon 3'UTR    22327324 chr11:118621775(-) A-I exon 3'UTR    22327324 chr11:118621699(-) A-I exon 3'UTR    21960545 chr11:118646589(-) A-I intron -    21960545 chr11:118620067(-) C-T exon 3'UTR    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DDX6	chr11:118620548-118620549(-) m6A 3'UTR       24981863 chr11:118620598-118620599(-) m6A 3'UTR       24981863//26404942 chr11:118620617-118620618(-) m6A 3'UTR       24284625//24981863//26404942 chr11:118620629-118620630(-) m6A 3'UTR       24284625//24981863//26404942 chr11:118620643-118620644(-) m6A 3'UTR       24284625//24981863//28052920//26404942 chr11:118620677-118620678(-) m6A 3'UTR       24284625//24981863//28052920//26404942 chr11:118620740-118620741(-) m6A 3'UTR       24284625//24981863//28052920//27773535 chr11:118620795-118620796(-) m6A 3'UTR       27773535 chr11:118621900-118621901(-) m6A 3'UTR       24981863 chr11:118621947-118621948(-) m6A 3'UTR       24981863//26404942 chr11:118621956-118621957(-) m6A 3'UTR       24981863//26404942 chr11:118622031-118622032(-) m6A 3'UTR       24981863 chr11:118622156-118622157(-) m6A 3'UTR//exon       27773535 chr11:118622174-118622175(-) m6A 3'UTR//exon       27773535 chr11:118622317-118622318(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr11:118622341-118622342(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr11:118622478-118622479(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118622505-118622506(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118622539-118622540(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118622592-118622593(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118622684-118622685(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118622700-118622701(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr11:118622709-118622710(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr11:118630685-118630686(-) m6A CDS//intron       22575960 chr11:118635955-118635956(-) m6A CDS//intron       27773535 chr11:118635995-118635996(-) m6A CDS//intron       27773535 chr11:118636037-118636038(-) m6A CDS       27773535 chr11:118638367-118638368(-) m6A exon//intron       27773535 chr11:118656732-118656733(-) m6A exon//intron       24981863 chr11:118656820-118656821(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr11:118656832-118656833(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085 chr11:118656848-118656849(-) m6A CDS//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:118656882-118656883(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085 chr11:118656937-118656938(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr11:118656944-118656945(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr11:118656964-118656965(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr11:118656979-118656980(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr11:118657030-118657031(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr11:118657052-118657053(-) Y 5'UTR//exon       25219674 chr11:118657067-118657068(-) m6A 5'UTR//exon       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:118657085-118657086(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr11:118657118-118657119(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr11:118657277-118657278(-) m6A exon//intron       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr11:118660741-118660742(-) m6A exon//intron       27773535 chr11:118660785-118660786(-) m6A exon//intron       27773535 chr11:118660803-118660804(-) m6A exon//intron       27773535 chr11:118661589-118661590(-) m6A 5'UTR//intron       24209618//24981863 chr11:118661626-118661627(-) m6A 5'UTR//intron       24209618//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DDX6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: DDX6

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.