Basic Information:

  VIRBase ID:  

VHID00396991

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          CDK8:  NM_001318368     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	CDK8
miRBase Accession/Entrez ID	MIMAT0004816	1024
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IDDHBA//K35

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDK8	chr13:26976368(+) A-I      intronic chr13:26963477(+) A-I      intronic chr13:26963480(+) A-I      intronic chr13:26972861(+) A-I      intronic chr13:26973240(+) A-I      intronic chr13:26973246(+) A-I      intronic chr13:26973264(+) A-I      intronic chr13:26973344(+) A-I      intronic chr13:26933896(+) A-I      intronic chr13:26972972(+) A-I      intronic chr13:26973347(+) A-I      intronic chr13:26943480(+) A-I      intronic chr13:26973356(+) A-I      intronic chr13:26973394(+) A-I      intronic chr13:26977446(+) A-I      intronic chr13:26933914(+) A-I      intronic chr13:26972980(+) A-I      intronic chr13:26933946(+) A-I      intronic chr13:26933953(+) A-I      intronic chr13:26948064(+) A-I      intronic chr13:26933978(+) A-I      intronic chr13:26933992(+) A-I      intronic chr13:26869026(+) A-I      intronic chr13:26934019(+) A-I      intronic chr13:26943490(+) A-I      intronic chr13:26934062(+) A-I      intronic chr13:26868372(+) A-I      intronic chr13:26934100(+) A-I      intronic chr13:26934338(+) A-I      intronic chr13:26973257(+) A-I      intronic chr13:26934361(+) A-I      intronic chr13:26934378(+) A-I      intronic chr13:26867662(+) A-I      intronic chr13:26945809(+) A-I      intronic chr13:26963374(+) A-I      intronic chr13:26934390(+) A-I      intronic chr13:26937203(+) A-I      intronic chr13:26937248(+) A-I      intronic chr13:26842592(+) A-I      intronic chr13:26937250(+) A-I      intronic chr13:26959816(+) A-I      intronic chr13:26937286(+) A-I      intronic chr13:26943746(+) A-I      intronic chr13:26945882(+) A-I      intronic chr13:26945955(+) A-I      intronic chr13:26948102(+) A-I      intronic chr13:26963380(+) A-I      intronic chr13:26948107(+) A-I      intronic chr13:26948131(+) A-I      intronic chr13:26948293(+) A-I      intronic chr13:26948303(+) A-I      intronic chr13:26963486(+) A-I      intronic chr13:26954334(+) A-I      intronic chr13:26954410(+) A-I      intronic chr13:26954491(+) A-I      intronic chr13:26954501(+) A-I      intronic chr13:26959601(+) A-I      intronic chr13:26959689(+) A-I      intronic chr13:26959714(+) A-I      intronic chr13:26842557(+) A-I      intronic chr13:26844420(+) A-I      intronic chr13:26865135(+) A-I      intronic chr13:26969570(+) A-I      intronic chr13:26868961(+) A-I      intronic chr13:26842570(+) A-I      intronic chr13:26842580(+) A-I      intronic chr13:26907451(+) A-I      intronic chr13:26842688(+) A-I      intronic chr13:26844272(+) A-I      intronic chr13:26844336(+) A-I      intronic chr13:26954386(+) A-I      intronic chr13:26959806(+) A-I      intronic chr13:26844337(+) A-I      intronic chr13:26973286(+) A-I      intronic chr13:26844341(+) A-I      intronic chr13:26844343(+) A-I      intronic chr13:26844451(+) A-I      intronic chr13:26850032(+) A-I      intronic chr13:26850093(+) A-I      intronic chr13:26945894(+) A-I      intronic chr13:26862199(+) A-I      intronic chr13:26862200(+) A-I      intronic chr13:26934411(+) A-I      intronic chr13:26863375(+) A-I      intronic chr13:26865181(+) A-I      intronic chr13:26867506(+) A-I      intronic chr13:26977468(+) A-I      intronic chr13:26867648(+) A-I      intronic chr13:26867674(+) A-I      intronic chr13:26972941(+) A-I      intronic chr13:26877481(+) A-I      intronic chr13:26933884(+) A-I      intronic chr13:26877499(+) A-I      intronic chr13:26877542(+) A-I      intronic chr13:26878322(+) A-I      intronic chr13:26878333(+) A-I      intronic chr13:26878346(+) A-I      intronic chr13:26868368(+) A-I      intronic chr13:26959849(+) A-I      intronic chr13:26879073(+) A-I      intronic chr13:26901872(+) A-I      intronic chr13:26901887(+) A-I      intronic chr13:26906537(+) A-I      intronic chr13:26906542(+) A-I      intronic chr13:26907320(+) A-I      intronic chr13:26907356(+) A-I      intronic chr13:26907357(+) A-I      intronic chr13:26907377(+) A-I      intronic chr13:26907406(+) A-I      intronic chr13:26918752(+) A-I      intronic chr13:26918757(+) A-I      intronic chr13:26919567(+) A-I      intronic chr13:26919684(+) A-I      intronic chr13:26919700(+) A-I      intronic chr13:26919717(+) A-I      intronic chr13:26919729(+) A-I      intronic chr13:26924516(+) A-I      intronic chr13:26924523(+) A-I      intronic chr13:26924844(+) A-I      intronic chr13:26929498(+) A-I      intronic chr13:26929575(+) A-I      intronic chr13:26943531(+) A-I      intronic chr13:26959708(+) A-I      intronic chr13:26943322(+) A-I      intronic chr13:26943489(+) A-I      intronic chr13:26972945(+) A-I      intronic chr13:26934364(+) A-I      intronic chr13:26880835(+) A-I      intronic chr13:26959617(+) A-I      intronic chr13:26963339(+) A-I      intronic chr13:26876265(+) A-I      intronic chr13:26934053(+) A-I      intronic chr13:26876222(+) A-I      intronic chr13:26945892(+) A-I      intronic chr13:26907333(+) A-I      intronic chr13:26919588(+) A-I      intronic chr13:26959753(+) A-I      intronic chr13:26934042(+) A-I      intronic chr13:26948217(+) A-I      intronic chr13:26842644(+) A-I      intronic chr13:26972894(+) A-I      intronic chr13:26954373(+) A-I      intronic chr13:26948223(+) A-I      intronic chr13:26904618(+) A-I      intronic chr13:26948063(+) A-I      intronic chr13:26972931(+) A-I      intronic chr13:26945853(+) A-I      intronic chr13:26842477(+) A-I      intronic chr13:26943375(+) A-I      intronic chr13:26943546(+) A-I      intronic chr13:26934036(+) A-I      intronic chr13:26963458(+) A-I      intronic chr13:26943536(+) A-I      intronic chr13:26943313(+) A-I      intronic chr13:26845800(+) A-I      intronic chr13:26943314(+) A-I      intronic chr13:26954446(+) A-I      intronic chr13:26973247(+) A-I      intronic chr13:26933970(+) A-I      intronic chr13:26844317(+) A-I      intronic chr13:26845904(+) A-I      intronic chr13:26954592(+) A-I      intronic chr13:26865109(+) A-I      intronic chr13:26943444(+) A-I      intronic chr13:26865076(+) A-I      intronic chr13:26946029(+) A-I      intronic chr13:26845898(+) A-I      intronic chr13:26954714(+) A-I      intronic chr13:26878281(+) A-I      intronic chr13:26933909(+) A-I      intronic chr13:26943380(+) A-I      intronic chr13:26867621(+) A-I      intronic chr13:26943795(+) A-I      intronic chr13:26959691(+) A-I      intronic chr13:26934351(+) A-I      intronic chr13:26954532(+) A-I      intronic chr13:26878183(+) A-I      intronic chr13:26844379(+) A-I      intronic chr13:26945817(+) A-I      intronic chr13:26842705(+) A-I      intronic chr13:26946007(+) A-I      intronic chr13:26878124(+) A-I      intronic chr13:26924831(+) A-I      intronic chr13:26901812(+) A-I      intronic chr13:26907460(+) A-I      intronic chr13:26933982(+) A-I      intronic chr13:26972842(+) A-I      intronic chr13:26842579(+) A-I      intronic chr13:26937689(+) A-I      intronic chr13:26879010(+) A-I      intronic chr13:26844370(+) A-I      intronic chr13:26963436(+) A-I      intronic chr13:26954498(+) A-I      intronic chr13:26929497(+) A-I      intronic chr13:26943521(+) A-I      intronic chr13:26954456(+) A-I      intronic chr13:26918641(+) A-I      intronic chr13:26907457(+) A-I      intronic chr13:26943765(+) A-I      intronic chr13:26959713(+) A-I      intronic chr13:26943381(+) A-I      intronic chr13:26973409(+) A-I      intronic chr13:26972950(+) A-I      intronic chr13:26878282(+) A-I      intronic chr13:26963438(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDK8	chr13:26933017(+) A-I intron -    21960545 chr13:26934390(+) A-I intron -    21960545 chr13:26891271(+) C-T intron -    22484847 chr13:26948217(+) A-G intron -    22484847 chr13:26948223(+) A-G intron -    22484847 chr13:26948312(+) T-A intron -    22484847 chr13:26963436(+) A-G intron -    22484847 chr13:26963438(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDK8	chr13:26828483-26828484(+) m6A 5'UTR       24209618//27773536 chr13:26828495-26828496(+) m6A 5'UTR       24209618//27773536 chr13:26828782-26828783(+) m6A CDS       24284625//24981863 chr13:26828830-26828831(+) m6A CDS       24284625//24981863 chr13:26911717-26911718(+) m6A CDS       - chr13:26978158-26978159(+) Y 3'UTR//CDS//exon       26075521 chr13:26979247-26979248(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDK8	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: CDK8

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.