Basic Information:

  VIRBase ID:  

VHID00396976

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART9-5p:  MIMAT0004816          CAPZA2:  NM_006136     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART9-5p	CAPZA2
miRBase Accession/Entrez ID	MIMAT0004816	830
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAPPA2//CAPZ

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CAPZA2	chr7:116533351(+) A-I      intronic chr7:116555312(+) A-I      intronic chr7:116554657(+) A-I      intronic chr7:116520861(+) A-I      intronic chr7:116555314(+) A-I      intronic chr7:116534255(+) A-I      intronic chr7:116533249(+) A-I      intronic chr7:116555242(+) A-I      intronic chr7:116509955(+) A-I      intronic chr7:116533370(+) A-I      intronic chr7:116520879(+) A-I      intronic chr7:116533302(+) A-I      intronic chr7:116555228(+) A-I      intronic chr7:116533240(+) A-I      intronic chr7:116533216(+) A-I      intronic chr7:116530725(+) A-I      intronic chr7:116534232(+) A-I      intronic chr7:116514910(+) A-I      intronic chr7:116515694(+) A-I      intronic chr7:116520891(+) A-I      intronic chr7:116534163(+) A-I      intronic chr7:116555151(+) A-I      intronic chr7:116554590(+) A-I      intronic chr7:116534341(+) A-I      intronic chr7:116534397(+) A-I      intronic chr7:116547769(+) A-I      intronic chr7:116528623(+) A-I      intronic chr7:116515792(+) A-I      intronic chr7:116515847(+) A-I      intronic chr7:116515857(+) A-I      intronic chr7:116516122(+) A-I      intronic chr7:116516173(+) A-I      intronic chr7:116516225(+) A-I      intronic chr7:116555339(+) A-I      intronic chr7:116556441(+) A-I      intronic chr7:116556490(+) A-I      intronic chr7:116556612(+) A-I      intronic chr7:116557518(+) A-I      intronic chr7:116554714(+) A-I      intronic chr7:116554671(+) A-I      intronic chr7:116521023(+) A-I      intronic chr7:116555103(+) A-I      intronic chr7:116556625(+) A-I      intronic chr7:116554695(+) A-I      intronic chr7:116510027(+) A-I      intronic chr7:116515045(+) A-I      intronic chr7:116504844(+) A-I      intronic chr7:116520943(+) A-I      intronic chr7:116515809(+) A-I      intronic chr7:116515798(+) A-I      intronic chr7:116533368(+) A-I      intronic chr7:116515880(+) A-I      intronic chr7:116555278(+) A-I      intronic chr7:116515873(+) A-I      intronic chr7:116557438(+) A-I      intronic chr7:116554782(+) A-I      intronic chr7:116516210(+) A-I      intronic chr7:116557585(+) A-I      intronic chr7:116547755(+) A-I      intronic chr7:116547724(+) A-I      intronic chr7:116548222(+) A-I      intronic chr7:116528749(+) A-I      intronic chr7:116528809(+) A-I      intronic chr7:116534254(+) A-I      intronic chr7:116504859(+) A-I      intronic chr7:116505871(+) A-I      intronic chr7:116533259(+) A-I      intronic chr7:116528642(+) A-I      intronic chr7:116515645(+) A-I      intronic chr7:116516183(+) A-I      intronic chr7:116554655(+) A-I      intronic chr7:116554709(+) A-I      intronic chr7:116554616(+) A-I      intronic chr7:116554538(+) A-I      intronic chr7:116554785(+) A-I      intronic chr7:116555296(+) A-I      intronic chr7:116521539(+) A-I      intronic chr7:116508709(+) A-I      intronic chr7:116520901(+) A-I      intronic chr7:116555267(+) A-I      intronic chr7:116521024(+) A-I      intronic chr7:116520862(+) A-I      intronic chr7:116515023(+) A-I      intronic chr7:116555236(+) A-I      intronic chr7:116548113(+) A-I      intronic chr7:116507818(+) A-I      intronic chr7:116520510(+) A-I      intronic chr7:116547770(+) A-I      intronic chr7:116533285(+) A-I      intronic chr7:116554595(+) A-I      intronic chr7:116547718(+) A-I      intronic chr7:116528814(+) A-I      intronic chr7:116556569(+) A-I      intronic chr7:116531839(+) A-I      intronic chr7:116528657(+) A-I      intronic chr7:116556530(+) A-I      intronic chr7:116556501(+) A-I      intronic chr7:116514909(+) A-I      intronic chr7:116528783(+) A-I      intronic chr7:116555094(+) A-I      intronic chr7:116557448(+) A-I      intronic chr7:116554642(+) A-I      intronic chr7:116505836(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CAPZA2	chr7:116504819(+) A-I intron -    21960545 chr7:116505870(+) A-I intron -    21960545 chr7:116547724(+) A-I intron -    21960545 chr7:116547755(+) A-I intron -    21960545 chr7:116547756(+) A-I intron -    21960545 chr7:116504860(+) A-G intron -    22484847 chr7:116508512(+) C-G intron -    22484847 chr7:116514909(+) A-G intron -    22484847 chr7:116515022(+) A-G intron -    22484847 chr7:116515023(+) A-G intron -    22484847 chr7:116515624(+) A-G intron -    22484847 chr7:116515740(+) A-G intron -    22484847 chr7:116515798(+) A-G intron -    22484847 chr7:116515809(+) A-G intron -    22484847 chr7:116516183(+) A-G intron -    22484847 chr7:116516210(+) A-G intron -    22484847 chr7:116520510(+) A-G intron -    22484847 chr7:116520855(+) A-G intron -    22484847 chr7:116520901(+) A-G intron -    22484847 chr7:116520952(+) A-G intron -    22484847 chr7:116521538(+) A-G intron -    22484847 chr7:116521539(+) A-G intron -    22484847 chr7:116533259(+) A-G intron -    22484847 chr7:116533285(+) A-G intron -    22484847 chr7:116533368(+) A-G intron -    22484847 chr7:116533387(+) A-G intron -    22484847 chr7:116533414(+) A-G intron -    22484847 chr7:116533435(+) A-G intron -    22484847 chr7:116534251(+) A-G intron -    22484847 chr7:116534254(+) A-G intron -    22484847 chr7:116534260(+) A-G intron -    22484847 chr7:116534348(+) A-G intron -    22484847 chr7:116548222(+) A-G intron -    22484847 chr7:116554642(+) A-G intron -    22484847 chr7:116555278(+) A-G intron -    22484847 chr7:116556493(+) A-G intron -    22484847 chr7:116556501(+) A-G intron -    22484847 chr7:116556530(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CAPZA2	chr7:116502595-116502596(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863 chr7:116513779-116513780(+) m6A exon//intron       24209618//25456834//24981863 chr7:116513821-116513822(+) m6A exon//intron       24981863 chr7:116528302-116528303(+) m6A exon//intron       27773535 chr7:116543381-116543382(+) Gm intron       16381836 chr7:116543382-116543383(+) Gm intron       16381836 chr7:116557874-116557875(+) m6A 3'UTR//CDS       24981863 chr7:116557926-116557927(+) m6A 3'UTR       24284625//24981863 chr7:116557989-116557990(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CAPZA2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART9-5p
Interactor2: CAPZA2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	Downregulation
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.